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Protein Page:
TLR1 (human)

Overview
TLR1 Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Binds MYD88 (via TIR domain). Interacts with CNPY3. Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2. Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine. Belongs to the Toll-like receptor family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Cellular Component: phagocytic vesicle membrane; membrane; integral to plasma membrane; plasma membrane
Molecular Function: transmembrane receptor activity; protein heterodimerization activity; receptor activity
Biological Process: positive regulation of tumor necrosis factor biosynthetic process; T-helper 1 type immune response; regulation of cytokine secretion; detection of diacylated bacterial lipoprotein; positive regulation of interleukin-6 biosynthetic process; detection of triacylated bacterial lipoprotein; signal transduction; MyD88-dependent toll-like receptor signaling pathway; macrophage activation; toll-like receptor 6 signaling pathway; innate immune response; immune response; inflammatory response
Reference #:  Q15399 (UniProtKB)
Alt. Names/Synonyms: CD281; DKFZp547I0610; DKFZp564I0682; KIAA0012; MGC104956; MGC126311; MGC126312; rsc786; TIL; TIL. LPRS5; TLR1; Toll-like receptor 1; Toll/interleukin-1 receptor-like protein
Gene Symbols: TLR1
Molecular weight: 90,291 Da
Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TLR1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 T48-p KDLSQKTtILNISQN
0 2 S678-p RNFVPGKsIVENIIT
  mouse

 
T51 KDLPLQTTTLDLSQN
S681 RNFVPGKSIVENIIN
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