Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Binds MYD88 (via TIR domain). Interacts with CNPY3. Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2. Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine. Belongs to the Toll-like receptor family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Cellular Component: phagocytic vesicle membrane; membrane; integral to plasma membrane; plasma membrane
Molecular Function: transmembrane receptor activity; protein heterodimerization activity; receptor activity
Biological Process: MyD88-dependent toll-like receptor signaling pathway; positive regulation of tumor necrosis factor biosynthetic process; regulation of cytokine secretion; macrophage activation; T-helper 1 type immune response; detection of diacylated bacterial lipoprotein; positive regulation of interleukin-6 biosynthetic process; toll-like receptor 6 signaling pathway; innate immune response; immune response; detection of triacylated bacterial lipoprotein; signal transduction; inflammatory response
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.