Home

TLR1 (human)

Overview TLR1 Participates in the innate immune response to microbial agents. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Binds MYD88 (via TIR domain). Interacts with CNPY3. Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2. Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine. Belongs to the Toll-like receptor family. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral Cellular Component: phagocytic vesicle membrane; membrane; integral to plasma membrane; plasma membrane Molecular Function: transmembrane receptor activity; protein heterodimerization activity; receptor activity Biological Process: positive regulation of tumor necrosis factor biosynthetic process; macrophage activation; positive regulation of interleukin-6 biosynthetic process; defense response to bacterium; toll-like receptor signaling pathway; innate immune response; pathogen-associated molecular pattern dependent induction by symbiont of host innate immunity; immune response; detection of triacylated bacterial lipoprotein; inflammatory response; signal transduction; microglial cell activation during immune response Reference #:  Q15399 (UniProtKB) Alt. Names/Synonyms: CD281; DKFZp547I0610; DKFZp564I0682; KIAA0012; MGC104956; MGC126311; MGC126312; rsc786; TIL; TIL. LPRS5; TLR1; Toll-like receptor 1; Toll/interleukin-1 receptor-like protein Gene Symbols: TLR1 Molecular weight: 90,291 Da Basal Isoelectric point: 6.62  Predict pI for various phosphorylation states CST Pathways:  NF-kB Signaling  |  Toll-like Receptors Pathway Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TLR1 1FYV - A=625-785 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE 246300 601194  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S44-p	IHVPKDLsQKTtILN
0	2		T48-p	KDLsQKTtILNIsQN
0	1		S53-p	KTtILNIsQNyISEL
0	1		Y56-p	ILNIsQNyISELWTS
0	1		K416-m3	SVSYDEKkGDCsWtK
0	1		S420-p	DEKkGDCsWtKSLLS
0	1		T422-p	KkGDCsWtKSLLSLN
0	1		S431-p	SLLSLNMsSNILTDT
0	1		T529-p	GDNPFQCtCELGEFV
0	2		S678-p	RNFVPGKsIVENIIt
0	1		T685-p	sIVENIItCIEKsyK
0	1		S690-p	IItCIEKsyKSIFVL
0	1		Y691-p	ItCIEKsyKSIFVLS

	mouse
P47	TRVPKDLPLQTTTLD
T51	KDLPLQTTTLDLSQN
S56	QTTTLDLSQNNISEL
N59	TLDLSQNNISELQTS
G419	SLRYSDGGIPCAWTQ
A423	SDGGIPCAWTQSLLV
T425	GGIPCAWTQSLLVLN
S434	SLLVLNLSSNMLTGS
T532	GNNPFQCTCELRDFV
S681	RNFVPGKSIVENIIN
N688	SIVENIINFIEKSYK
S693	IINFIEKSYKSIFVL
Y694	INFIEKSYKSIFVLS

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.