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Protein Page:
INDOL1 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
INDOL1 Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism. Belongs to the indoleamine 2,3-dioxygenase family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; EC 1.13.11.-; Oxidoreductase
Cellular Component: cytoplasm
Molecular Function: p-cumate 2,3-dioxygenase activity; 2-aminophenol 1,6-dioxygenase activity; 2,3-dihydroxy-p-cumate dioxygenase activity; 3,5-dichlorocatechol 1,2-dioxygenase activity; metal ion binding; hydroquinone 1,2-dioxygenase activity; protocatechuate 3,4-dioxygenase type II activity; 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity; indoleamine 2,3-dioxygenase activity; oxidoreductase activity; 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity; dihydroxyfluorene dioxygenase activity; styrene dioxygenase activity; 2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity; 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity; catechol dioxygenase activity; 3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity; phenanthrene dioxygenase activity; 2,3-dihydroxy DDT 1,2-dioxygenase activity; 4-hydroxycatechol 1,2-dioxygenase activity; 2,2',3-trihydroxybiphenyl dioxygenase activity; chlorocatechol 1,2-dioxygenase activity; 1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity; carbazole 1,9a-dioxygenase activity; 3,4-dihydroxyphenanthrene dioxygenase activity; tryptophan 2,3-dioxygenase activity; dihydroxydibenzothiophene dioxygenase activity; 2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity; dioxygenase activity; heme binding; 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity
Biological Process: tryptophan catabolic process to kynurenine
Reference #:  Q8R0V5 (UniProtKB)
Alt. Names/Synonyms: AI265623; C230043N17Rik; I23O2; IDO-2; Ido2; Indol1; Indoleamine 2,3-dioxygenase 2; Indoleamine 2,3-dioxygenase-like protein 1; indoleamine-pyrrole 2,3 dioxygenase-like 1; Indoleamine-pyrrole 2,3-dioxygenase-like protein 1; MGC31194
Gene Symbols: Ido2
Molecular weight: 44,468 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
Select Structure to View Below

INDOL1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 2 K133-ac LVLTNWTkRNPEGPL
0 1 S282 GIEHCKESVGFLHRM
0 1 K298-ub DYMPPSHkAFLEDLH
0 1 K383-ub TAMLSFLkSVREKTM
  human

 
K140 LVLTNWTKKDPDGFL
S289-p GIRHSKEsGDFLYRM
K305 DYMPPSHKAFIEDIH
K392 TAVMSFLKSVRDKTL
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