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Protein Page:
DRD4 (human)

Overview
DRD4 Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR
Cellular Component: membrane; cell soma; integral to plasma membrane; dendritic spine; plasma membrane; terminal button; cell cortex; vesicle membrane
Molecular Function: dopamine D2 receptor-like receptor activity; identical protein binding; protein binding; potassium channel regulator activity; dopamine receptor activity; dopamine binding; drug binding; SH3 domain binding
Biological Process: circadian rhythm; synaptic transmission, dopaminergic; fear response; behavioral fear response; positive regulation of dopamine uptake; short-term memory; adult locomotory behavior; activation of MAPK activity; positive regulation of kinase activity; regulation of neurotransmitter secretion; regulation of calcium-mediated signaling; behavioral response to ethanol; dopamine metabolic process; dopamine receptor, adenylate cyclase inhibiting pathway; regulation of inhibitory postsynaptic membrane potential; negative regulation of cAMP biosynthetic process; behavioral response to cocaine; negative regulation of protein secretion; response to amphetamine; regulation of dopamine metabolic process; negative regulation of adenylate cyclase activity; social behavior; regulation of circadian rhythm; arachidonic acid secretion; cellular calcium ion homeostasis; olfactory learning; response to steroid hormone stimulus; retina development in camera-type eye; photoperiodism; dopamine receptor signaling pathway; positive regulation of sodium:hydrogen antiporter activity
Reference #:  P21917 (UniProtKB)
Alt. Names/Synonyms: D(2C) dopamine receptor; D(4) dopamine receptor; D4DR; Dopamine D4 receptor; dopamine receptor D4; DRD4
Gene Symbols: DRD4
Molecular weight: 48,361 Da
Basal Isoelectric point: 8.79  Predict pI for various phosphorylation states
Select Structure to View Below

DRD4

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T159-p QLLLIGAtWLLsAAV
0 1 S163-p IGAtWLLsAAVAAPV
0 1 S196 DRDYVVYSSVCSFFL
1 2 S239-p GRAPRRPsGPGPPsP
1 1 S245-p PsGPGPPsPTPPAPR
  mouse

 
T154 QLLLIAATWLLSAAV
S158 IAATWLLSAAVASPV
S191-p NRDYVVYsSVCSFFL
S234 SRAPRRPSGPGPPVS
V240 PSGPGPPVSDPTQGP
  rat

 
T154 QLLLIAATWLLSAAV
S158 IAATWLLSAAVAAPV
S191 DRDYVVYSSICSFFL
S234 SRAPRRPSGPGPPVS
V240 PSGPGPPVSDPTQGP
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