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Protein Page:
ENDOG (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ENDOG Cleaves DNA at double-stranded (DG)n.(DC)n and at single-stranded (DC)n tracts. In addition to deoxyribonuclease activities, also has ribonuclease (RNase) and RNase H activities. Capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. Homodimer. Belongs to the DNA/RNA non-specific endonuclease family. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.30.-; Apoptosis; Deoxyribonuclease; Mitochondrial; Ribonuclease
Cellular Component: mitochondrion
Molecular Function: nuclease activity; nucleic acid binding; endonuclease activity; metal ion binding
Biological Process: response to antibiotic; positive regulation of apoptosis; in utero embryonic development; DNA fragmentation during apoptosis; DNA recombination
Reference #:  Q14249 (UniProtKB)
Alt. Names/Synonyms: Endo G; ENDOG; endonuclease G; Endonuclease G, mitochondrial; FLJ27463; NUCG
Gene Symbols: ENDOG
Molecular weight: 32,620 Da
Basal Isoelectric point: 9.53  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ENDOG

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T9-p RALRAGLtLAsGAGL
0 1 S12-p RAGLtLAsGAGLGAV
0 1 K66-ub RGPGELAkYGLPGLA
0 3 K76-ub LPGLAQLkSRESYVL
0 1 K153-ub ANHRWSQkAMDDTFY
0 1 K181-ub NAWNNLEkYSRSLTR
0 1 K210-ub PRTEADGkSYVkYQV
0 1 K214 ADGkSYVKYQVIGKN
0 1 K214-ub ADGkSYVkYQVIGKN
0 1 K290-ub LARAGSLkAITAGSK
  mouse

 
T9 RALRAGLTLALGAGL
L12 RAGLTLALGAGLGAA
K63 GGTGELAKYGLPGVA
R73 LPGVAQLRSRESYVL
R150 ANHRWSQRAMDDTFY
R178 NAWNNLERYSRSLTR
K207 PRTEADGKSYVkYQV
K211-ac ADGKSYVkYQVIGKN
K211 ADGKSYVKYQVIGKN
K287 LARAGNLKAITAGSK
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