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Protein Page:
HEYL (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HEYL Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Belongs to the HEY family. Note: This description may include information from UniProtKB.
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; AF-1 domain binding; transcription corepressor activity; transcription factor binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of neuron differentiation; glomerulus development; mesenchymal cell development
Reference #:  Q9NQ87 (UniProtKB)
Alt. Names/Synonyms: BHLHB33; Class B basic helix-loop-helix protein 33; Hairy-related transcription factor 3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related with YRPW motif-like; Hairy/enhancer-of-split related with YRPW motif-like protein; HEY-like protein; HEY3; HEYL; hHeyL; hHRT3; HRT-3; HRT3; MGC12623
Gene Symbols: HEYL
Molecular weight: 35,087 Da
Basal Isoelectric point: 10.69  Predict pI for various phosphorylation states
Select Structure to View Below

HEYL

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K53-ac KHRGIIEkRRRDRIN
0 1 K76-ub LVPTAFEkQGSSKLE
0 1 S239-p ARRNVLPsRGASSTR
0 4 T256-p RPLERPAtPVPVAPS
  mouse

 
K53 KRRGIIEKRRRDRIN
K76 LVPTAFEKQGSSKLE
S239 TRRNLLPSRGVTSTQ
A256 HLPERPAAPPPTALD
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