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HEYL
Downstream effector of Notch signaling which may be required for cardiovascular development. Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Belongs to the HEY family. Note: This description may include information from UniProtKB.
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Cellular Component: cytoplasm; nucleus
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Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; AF-1 domain binding; transcription factor activity; transcription corepressor activity; transcription factor binding
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Biological Process: Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of neuron differentiation; glomerulus development; mesenchymal cell development
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Reference #:
Q9NQ87 (UniProtKB)
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| Alt. Names/Synonyms: BHLHB33; Class B basic helix-loop-helix protein 33; Hairy-related transcription factor 3; hairy/enhancer-of-split related with YRPW motif 3; hairy/enhancer-of-split related with YRPW motif-like; Hairy/enhancer-of-split related with YRPW motif-like protein; HEY-like protein; HEY3; HEYL; hHeyL; hHRT3; HRT-3; HRT3; MGC12623 |
| Gene Symbols: HEYL |
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Molecular weight: 35,087 Da
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Basal Isoelectric point: 10.69
Predict pI for various phosphorylation states
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