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Protein Page:
PIGO (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PIGO Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond. Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transferase; Endoplasmic reticulum; EC 2.-.-.-; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: transferase activity
Biological Process: cellular protein metabolic process; preassembly of GPI anchor in ER membrane; GPI anchor biosynthetic process; C-terminal protein lipidation; post-translational protein modification
Reference #:  Q8TEQ8 (UniProtKB)
Alt. Names/Synonyms: DKFZp434M222; FLJ00135; GPI ethanolamine phosphate transferase 3; MGC20536; MGC3079; phosphatidylinositol glycan anchor biosynthesis, class O; phosphatidylinositol glycan, class O; Phosphatidylinositol-glycan biosynthesis class O protein; PIG-O; PIGO; RP11-182N22.4
Gene Symbols: PIGO
Molecular weight: 118,699 Da
Basal Isoelectric point: 8.38  Predict pI for various phosphorylation states
Select Structure to View Below

PIGO

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 K103-ub VSLPFLGkLSSLQRI
0 1 K251-ub HHPEMAKkLSQMDQV
0 1 S737-p PRLRVLVsGASMVLP
0 1 K768-ub KPVTVLVkAGAGAPR
0 2 Y795-p TSQADLDyVVPQIYR
0 1 Y1016-p LLQLGLKyLFILGIQ
0 1 S1032-p LACALAAsILRRHLM
  mouse

 
K103 VSVPFLGKLGSLQRI
K251 HHPEMAKKLSQMDQV
A738 PRLRALVAGASAVLP
K769 RPVTVLVKAGAATSR
Y796 TSQADLDYVVPQIYR
Y1020 LLQLGLKYLFILGAQ
S1036 LACALAASILRRHLM
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