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Protein Page:
BRSK1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BRSK1 a serine/threonine protein kinase of the CAMK group. Closely related to AMPK. Activated by the kinase LKB1. Acts as checkpoint kinase upon DNA damage induced by UV or methyl methane sulfonate. Phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo. Translocates from the cytoplasm to the nucleus in response to UV- or MMS-induced DNA damage. BRSK1 and BRSK2 are required for neuronal polarization. Widely expressed with highest levels in the brain and testis. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, CAMK; EC 2.7.11.26; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CAMK group; CAMKL family; BRSK subfamily
Chromosomal Location of Human Ortholog: 19q13.4
Cellular Component: centrosome; synaptic vesicle; cytoplasm; plasma membrane; nucleolus; cell junction; nucleus
Molecular Function: protein serine/threonine kinase activity; gamma-tubulin binding; tau-protein kinase activity; magnesium ion binding; protein kinase binding; ATP binding
Biological Process: neuron differentiation; axonogenesis; establishment of cell polarity; neurotransmitter secretion; response to ionizing radiation; G2/M transition DNA damage checkpoint; response to DNA damage stimulus; centrosome duplication; protein amino acid phosphorylation; response to UV
Reference #:  Q8TDC3 (UniProtKB)
Alt. Names/Synonyms: BR serine/threonine kinase 1; BR serine/threonine-protein kinase 1; BRSK1; FLJ43009; KIAA1811; protein kinase SAD1A; SAD1; SAD1 kinase; Serine/threonine-protein kinase SAD-B
Gene Symbols: BRSK1
Molecular weight: 85,087 Da
Basal Isoelectric point: 9.39  Predict pI for various phosphorylation states
Select Structure to View Below

BRSK1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S12 AKEGGGGSPAYHLPH
0 1 K63 TGQKVAIKIVNREKL
0 1 K167 ENLLLDEKNNIRIAD
6 1 T189-p VGDSLLEtSCGSPHY
0 1 S190 GDSLLEtSCGSPHYA
1 0 S193 LLEtSCGSPHYACPE
0 8 K272 MIEVEPEKRLsLEQI
0 2 S275-p VEPEKRLsLEQIQKH
0 1 S308 GRRVAMRSLPSNGEL
0 1 S311 VAMRSLPSNGELDPD
0 4 Y351 ENQEKMIYYLLLDRK
0 2 S384-p PPRKRVDsPMLSRHG
0 7 S399-p KRRPERKsMEVLsIT
0 1 S404-p RKsMEVLsITDAGGG
0 3 S413-p TDAGGGGsPVPtRRA
0 1 T417-p GGGsPVPtRRALEMA
0 4 S427-p ALEMAQHsQRSRsVS
0 1 S430 MAQHsQRSRsVSGAS
0 2 S432-p QHsQRSRsVSGASTG
0 1 S441 SGASTGLSSsPLSsP
0 2 S442 GASTGLSSsPLSsPR
0 5 S443-p ASTGLSSsPLSsPRS
0 2 S447-p LSSsPLSsPRSPVFS
0 6 S450 sPLSsPRSPVFSFSP
0 2 S454 sPRSPVFSFSPEPGA
0 1 R466 PGAGDEARGGGSPTS
0 1 T472 ARGGGSPTSKTQTLP
0 1 S473 RGGGSPTSKTQTLPS
0 1 R481 KTQTLPSRGPRGGGA
0 1 R484 TLPSRGPRGGGAGEQ
0 2 R498 QPPPPSARSTPLPGP
0 2 S499 PPPPSARSTPLPGPP
0 1 T500 PPPSARSTPLPGPPG
0 9 S508-p PLPGPPGsPRSSGGT
0 1 S511 GPPGsPRSSGGTPLH
0 2 S512 PPGsPRSSGGTPLHS
0 3 T515 sPRSSGGTPLHSPLH
0 5 S519 SGGTPLHSPLHTPRA
0 1 R525 HSPLHTPRASPTGTP
0 3 S527 PLHTPRASPTGTPGT
0 2 T529 HTPRASPTGTPGTTP
0 1 T531 PRASPTGTPGTTPPP
0 1 T534 SPTGTPGTTPPPSPG
0 2 T535 PTGTPGTTPPPSPGG
0 1 S539 PGTTPPPSPGGGVGG
0 1 R550 GVGGAAWRSRLNSIR
0 1 S551 VGGAAWRSRLNSIRN
0 1 S555 AWRSRLNSIRNSFLG
0 1 S559 RLNSIRNSFLGsPRF
0 19 S563-p IRNSFLGsPRFHRRK
0 8 T583-p AEEMSSLtPESsPEL
0 3 S586 MSSLtPESsPELAKR
0 7 S587-p SSLtPESsPELAKRS
0 2 K659 GGPSVFQKPVRFQVD
0 2 S676 SSEGPEPSPRRDGSG
0 1 T734 DEKNGAQTRPAGAPP
0 1 A739 AQTRPAGAPPRSLQP
0 2 P751 LQPPPGRPDPELSSS
0 1 T772-p KDKKLLAtNGTPLP_
  BRSK1 iso2  
S13 TLGKGPESPDGDVSV
K79-ub TGQKVAIkIVNREKL
K183 ENLLLDEKNNIRIAD
T205-p VGDSLLEtSCGsPHY
S206 GDSLLEtSCGsPHYA
S209-p LLEtSCGsPHYACPE
K288-ac MIEVEPEkRLSLEQI
S291 VEPEkRLSLEQIQKH
S324 GRRVAMRSLPSNGEL
S327 VAMRSLPSNGELDPD
Y367 ENQEKMIYYLLLDRK
S400 PPRKRVDSPMLSRHG
S415 KRRPERKSMEVLSIT
S420 RKSMEVLSITDAGGG
S429 TDAGGGGSPVPTRRA
T433 GGGSPVPTRRALEMA
S443 ALEMAQHSQRSRSVS
S446 MAQHSQRSRSVSGAS
S448 QHSQRSRSVSGASTG
S457 SGASTGLSSSPLSSP
S458 GASTGLSSSPLSSPR
S459 ASTGLSSSPLSSPRS
S463 LSSSPLSSPRSPVFS
S466 SPLSSPRSPVFSFSP
S470 SPRSPVFSFSPEPGA
R482 PGAGDEARGGGSPTS
T488 ARGGGSPTSKTQTLP
S489 RGGGSPTSKTQTLPS
R497 KTQTLPSRGPRGGGA
R500 TLPSRGPRGGGAGEQ
R514-m1 QPPPPSArSTPLPGP
S515 PPPPSArSTPLPGPP
T516 PPPSArSTPLPGPPG
S524-p PLPGPPGsPRSSGGT
S527 GPPGsPRSSGGTPLH
S528 PPGsPRSSGGTPLHS
T531 sPRSSGGTPLHSPLH
S535 SGGTPLHSPLHTPRA
R541 HSPLHTPRASPTGTP
S543 PLHTPRASPTGTPGT
T545 HTPRASPTGTPGTTP
T547 PRASPTGTPGTTPPP
T550 SPTGTPGTTPPPSPG
T551 PTGTPGTTPPPSPGG
S555 PGTTPPPSPGGGVGG
R566 GVGGAAWRSRLNSIR
S567 VGGAAWRSRLNSIRN
S571 AWRSRLNSIRNSFLG
S575 RLNSIRNSFLGsPRF
S579-p IRNSFLGsPRFHRRK
T599-p AEEMSSLtPESSPEL
S602 MSSLtPESSPELAKR
S603 SSLtPESSPELAKRS
K675 GGPSVFQKPVRFQVD
S692 SSEGPEPSPRRDGSG
T750-p DEKNGAQtRPAGAPP
A755 AQtRPAGAPPRSLQP
P767 LQPPPGRPDPELSSS
T788 KDKKLLATNGTPLP_
  mouse

 
S12-p SKEGGGGsPAYHLPH
K63 TGQKVAVKIVNREKL
K167-ub ENLLLDEkNNIRIAD
T189-p VGDSLLEtsCGSPHY
S190-p GDSLLEtsCGSPHYA
S193 LLEtsCGSPHYACPE
K272 MIEVEPEKRLsLEQI
S275-p VEPEKRLsLEQIQKH
S308-p GRRVAMRsLPsNGEL
S311-p VAMRsLPsNGELDPD
Y351 ENQEKMIYYLLLDRK
S384-p PPRKRVDsPMLSRHG
S399-p KRRPERKsMEVLSIT
S404 RKsMEVLSITDAGSG
S413-p TDAGSGGsPVPTRRA
T417 SGGsPVPTRRALEMA
S427-p ALEMAQHsQRsRsVS
S430-p MAQHsQRsRsVSGAS
S432-p QHsQRsRsVSGASTG
S441-p SGASTGLsssPLSsP
S442-p GASTGLsssPLSsPR
S443-p ASTGLsssPLSsPRs
S447-p LsssPLSsPRsPVFs
S450-p sPLSsPRsPVFsFSP
S454-p sPRsPVFsFSPEPGA
R466-m1 PGAGDEArGGGSPts
T472-p ArGGGSPtsKTQTLP
S473-p rGGGSPtsKTQTLPS
R481-m1 KTQTLPSrGPrGGGA
R484-m1 TLPSrGPrGGGAGEQ
R498-m1 QPPPPSArstPLPGP
S499-p PPPPSArstPLPGPP
T500-p PPPSArstPLPGPPG
S508-p PLPGPPGsPRssGGt
S511-p GPPGsPRssGGtPLH
S512-p PPGsPRssGGtPLHs
T515-p sPRssGGtPLHsPLH
S519-p sGGtPLHsPLHTPrA
R525-m1 HsPLHTPrAsPtGtP
S527-p PLHTPrAsPtGtPGt
T529-p HTPrAsPtGtPGttP
T531-p PrAsPtGtPGttPPP
T534-p sPtGtPGttPPPsPG
T535-p PtGtPGttPPPsPGG
S539-p PGttPPPsPGGGVGG
R550-m1 GVGGAAWrsRLNsIR
S551-p VGGAAWrsRLNsIRN
S555-p AWrsRLNsIRNsFLG
S559-p RLNsIRNsFLGsPRF
S563-p IRNsFLGsPRFHRRK
T583-p AEEMSSLtPEssPEL
S586-p MSSLtPEssPELAKR
S587-p SSLtPEssPELAKRS
K659 GGPSVFQKPVRFQVD
S676-p SSEGPEPsPRRDGSS
T734 DEKNGAQTRPAGtPP
T739-p AQTRPAGtPPRSLQP
S751-p LQPPPGRsDPDLSSS
T772 KDKKLLATNGTPLP_
  rat

 
S12 SKEGGGGSPAYHLPH
K63 TGQKVAVKIVNREKL
K167 ENLLLDEKNNIRIAD
T189-p VGDSLLEtSCGSPHY
S190 GDSLLEtSCGSPHYA
S193 LLEtSCGSPHYACPE
K272 MIEVEPEKRLSLEQI
S275 VEPEKRLSLEQIQKH
S308 GRRVAMRSLPsNGEL
S311-p VAMRSLPsNGELDPD
Y351-p ENQEKMIyYLLLDRK
S384 PPRKRVDSPMLSRHG
S399-p KRRPERKsMEVLSIT
S404 RKsMEVLSITDAGSG
S413 TDAGSGGSPVPTRRA
T417 SGGSPVPTRRALEMA
S427 ALEMAQHSQRSRSVS
S430 MAQHSQRSRSVSGAS
S432 QHSQRSRSVSGASTG
S441 SGASTGLSSsPLSsP
S442 GASTGLSSsPLSsPR
S443-p ASTGLSSsPLSsPRs
S447-p LSSsPLSsPRsPVFS
S450-p sPLSsPRsPVFSFSP
S454 sPRsPVFSFSPEPGV
R466 PGVGDEARGGGSPTS
T472 ARGGGSPTSKTQTLP
S473 RGGGSPTSKTQTLPS
R481 KTQTLPSRGPRGGGA
R484 TLPSRGPRGGGAGEQ
R498 QPPPPSARSTPLPGP
S499 PPPPSARSTPLPGPP
T500 PPPSARSTPLPGPPG
S508-p PLPGPPGsPRSSGGT
S511 GPPGsPRSSGGTPLH
S512 PPGsPRSSGGTPLHS
T515 sPRSSGGTPLHSPLH
S519 SGGTPLHSPLHTPRA
R525 HSPLHTPRASPTGTP
S527 PLHTPRASPTGTPGT
T529 HTPRASPTGTPGTTP
T531 PRASPTGTPGTTPPP
T534 SPTGTPGTTPPPSPG
T535 PTGTPGTTPPPSPGG
S539 PGTTPPPSPGGGVGG
R550 GVGGAAWRSRLNSIR
S551 VGGAAWRSRLNSIRN
S555 AWRSRLNSIRNSFLG
S559 RLNSIRNSFLGsPRF
S563-p IRNSFLGsPRFHRRK
T583-p AEEMSSLtPEssPEL
S586-p MSSLtPEssPELAKR
S587-p SSLtPEssPELAKRS
K659-ub GGPSVFQkPVRFQVD
S676 SSEGPEPSPRRDGSS
T734 DEKNGAQTRPAGTPP
T739 AQTRPAGTPPRSLQP
P751 LQPPPGRPDPDLSSS
T772 KDKKLLATNGTPLP_
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