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maspin (human)

Overview maspin Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Interacts with IRF6. Normal mammary epithelial cells. Belongs to the serpin family. Ov-serpin subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Cellular Component: extracellular space; cytoplasm Molecular Function: serine-type endopeptidase inhibitor activity; protein binding Biological Process: extracellular matrix organization and biogenesis; regulation of proteolysis; morphogenesis of an epithelium; cell motility; regulation of epithelial cell proliferation Reference #:  P36952 (UniProtKB) Alt. Names/Synonyms: Maspin; Peptidase inhibitor 5; PI-5; PI5; protease inhibitor 5 (maspin); serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5; Serpin B5; serpin peptidase inhibitor, clade B (ovalbumin), member 5; SERPINB5; SPB5 Gene Symbols: SERPINB5 Molecular weight: 42,100 Da Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below maspin 1WZ9 - A/B=1-375 (human) 1XQG - A/B=1-375 (human) 1XQJ - A=1-375 (human) 1XU8 - A/B=1-375 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1WZ9 1XQG 1XQJ 1XU8  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S9-p	DALQLANsAFAVDLF
1	1		T50-p	QVGAKGDtANEIGQV
1	1		S97-p	KRLYVDKsLNLSTEF
1	1		T118-p	PYAKELEtVDFKDKL
0	1		S135-p	TKGQINNsIKDLTDG
1	1		T157-p	DNSVNDQtKILVVNA
1	1		S240-p	PKDVEDEsTGLEKIE
0	1		K277-a	KLSIPKFkVEkMIDP
0	1		K280-a	IPKFkVEkMIDPKAC
1	1		S298-p	LGLKHIFsEDTSDFS
1	1		T310-p	DFSGMSEtKGVALsN
1	1		S316-p	EtKGVALsNVIHKVC
0	1		Y356-p	NADHPFIyIIRHNKT

	mouse
S9	DALRLANSAFAVDLF
T50	QVGTKGDTANEIGQV
S97	KRLYIDKSLNPSTEF
T118	PYAKELETVDFKDKL
S135	TKGQINSSIKELTDG
T157	ENSISDQTKILVVNA
S240	PKDVEDESTGLEKIE
K277	KLSLPKFKVEKMIDP
K280	LPKFKVEKMIDPKAS
N298	LGLKSLFNESTSDFS
T310	DFSGMSETKGVSLSN
S316	ETKGVSLSNVIHRVC
Y356	NADHPFIYIIRHNKT

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