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Protein Page:
maspin (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
maspin Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. Interacts with IRF6. Normal mammary epithelial cells. Belongs to the serpin family. Ov-serpin subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: extracellular space; cytoplasm
Molecular Function: serine-type endopeptidase inhibitor activity; protein binding
Biological Process: extracellular matrix organization and biogenesis; regulation of proteolysis; morphogenesis of an epithelium; cell motility; regulation of epithelial cell proliferation
Reference #:  P36952 (UniProtKB)
Alt. Names/Synonyms: Maspin; Peptidase inhibitor 5; PI-5; PI5; protease inhibitor 5 (maspin); serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5; Serpin B5; serpin peptidase inhibitor, clade B (ovalbumin), member 5; SERPINB5; SPB5
Gene Symbols: SERPINB5
Molecular weight: 42,100 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

maspin

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S9-p DALQLANsAFAVDLF
1 1 T50-p QVGAKGDtANEIGQV
1 1 S97-p KRLYVDKsLNLSTEF
0 1 K114-ac STKRPYAkELEtVDF
1 1 T118-p PYAkELEtVDFKDKL
0 1 S135-p TKGQINNsIKDLTDG
1 1 T157-p DNSVNDQtKILVVNA
1 1 S240-p PKDVEDEsTGLEKIE
0 1 K277-ac KLSIPKFkVEkMIDP
0 1 K280-ac IPKFkVEkMIDPKAC
1 1 S298-p LGLKHIFsEDTSDFS
1 1 T310-p DFSGMSEtKGVALsN
1 1 S316-p EtKGVALsNVIHKVC
0 1 Y356-p NADHPFIyIIRHNKT
  mouse

 
S9 DALRLANSAFAVDLF
T50 QVGTKGDTANEIGQV
S97 KRLYIDKSLNPSTEF
K114 STKRPYAKELETVDF
T118 PYAKELETVDFKDKL
S135 TKGQINSSIKELTDG
T157 ENSISDQTKILVVNA
S240 PKDVEDESTGLEKIE
K277 KLSLPKFKVEKMIDP
K280 LPKFKVEKMIDPKAS
N298 LGLKSLFNESTSDFS
T310 DFSGMSETKGVSLSN
S316 ETKGVSLSNVIHRVC
Y356 NADHPFIYIIRHNKT
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