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GLUT2
an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Present at high levels in the plasma membrane of pancreatic b-cells where it initiates the first step in glucose-stimulated insulin secretion, a glucose metabolism-dependent signaling mechanism. May mediate the bidirectional transfer of glucose across the plasma membrane of hepatocytes. May also participate with the Na( +2)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Required for glucose sensitivity in the hypothalamus and brain stem. Involved in the control of food intake and stimulation of glucose uptake by peripheral tissues. Note: This description may include information from UniProtKB.
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| Protein type: Transporter; Membrane protein, integral |
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Cellular Component: membrane; integral to plasma membrane; basolateral plasma membrane; brush border membrane; plasma membrane; cytosol; endosome
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Molecular Function: D-glucose transmembrane transporter activity; dehydroascorbic acid transporter activity; glucose transmembrane transporter activity; insulin receptor binding; hexose transmembrane transporter activity
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Biological Process: response to peptide hormone stimulus; hexose transport; carbohydrate metabolic process; fructose transport; response to glucose stimulus; energy reserve metabolic process; glucose transport; regulation of insulin secretion; endocrine pancreas development; transmembrane transport
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Reference #:
P11168 (UniProtKB)
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| Alt. Names/Synonyms: Glucose transporter type 2, liver; GLUT-2; GLUT2; GTR2; SLC2A2; solute carrier family 2 (facilitated glucose transporter), member 2; Solute carrier family 2, facilitated glucose transporter member 2 |
| Gene Symbols: SLC2A2 |
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Molecular weight: 57,490 Da
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Basal Isoelectric point: 8.09
Predict pI for various phosphorylation states
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CST Pathways:
Warburg Effect
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