Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
GLUT2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GLUT2 an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Present at high levels in the plasma membrane of pancreatic b-cells where it initiates the first step in glucose-stimulated insulin secretion, a glucose metabolism-dependent signaling mechanism. May mediate the bidirectional transfer of glucose across the plasma membrane of hepatocytes. May also participate with the Na( +2)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Required for glucose sensitivity in the hypothalamus and brain stem. Involved in the control of food intake and stimulation of glucose uptake by peripheral tissues. Note: This description may include information from UniProtKB.
Protein type: Transporter; Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass
Cellular Component: membrane; integral to plasma membrane; cytoplasm; plasma membrane; brush border
Molecular Function: D-glucose transmembrane transporter activity; dehydroascorbic acid transporter activity; glucose transmembrane transporter activity; hexose transmembrane transporter activity
Biological Process: hexose transport; carbohydrate metabolic process; energy reserve metabolic process; glucose transport; endocrine pancreas development; regulation of insulin secretion; transmembrane transport
Reference #:  P11168 (UniProtKB)
Alt. Names/Synonyms: Glucose transporter type 2, liver; GLUT-2; GLUT2; GTR2; SLC2A2; solute carrier family 2 (facilitated glucose transporter), member 2; Solute carrier family 2, facilitated glucose transporter member 2
Gene Symbols: SLC2A2
Molecular weight: 57,490 Da
Basal Isoelectric point: 8.09  Predict pI for various phosphorylation states
CST Pathways:  Warburg Effect
Select Structure to View Below

GLUT2

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y245 FCPESPRYLYIKLDE
0 1 K271 RGYDDVTKDINEMRK
0 1 K271 RGYDDVTKDINEMRK
0 1 R277 TKDINEMRKEREEAS
0 2 S397 LNKFSWMSYVSMIAI
0 2 Y398 NKFSWMSYVSMIAIF
0 1 K490 KVPETKGKSFEEIAA
1 0 S491 VPETKGKSFEEIAAE
1 0 S503 AAEFQKKSGSAHRPK
1 0 S505 EFQKKSGSAHRPKAA
1 0 A512 SAHRPKAAVEMKFLG
0 4 T523-p KFLGATEtV______
  mouse

 
Y244 FCPESPRYLYIKLEE
K270-ac RGTEDVTkDINEMkK
K270-ub RGTEDVTkDINEMkK
K276-ub TkDINEMkKEKEEAS
S396-p LDKFAWMsyVSMTAI
Y397-p DKFAWMsyVSMTAIF
K489-ub KVPETKGkSFEEIAA
S490 VPETKGkSFEEIAAE
S502 AAEFRKKSGSAPPRK
S504 EFRKKSGSAPPRKAA
A511 SAPPRKAAVQMEFLA
S522-p EFLASSEsV______
  rat

 
Y243-p FCPESPRyLYLNLEE
K269 RGTEDITKDINEMRK
K269 RGTEDITKDINEMRK
R275 TKDINEMRKEKEEAS
S395 LDKFTWMSYVSMTAI
Y396 DKFTWMSYVSMTAIF
K488 KVPETKGKsFDEIAA
S489-p VPETKGKsFDEIAAE
S501-p AAEFRKKsGsAPPRK
S503-p EFRKKsGsAPPRKAt
T510-p sAPPRKAtVQMEFLG
T521 EFLGSSETV______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.