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Protein Page:
BRIP1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
BRIP1 a DNA-dependent ATPase and DNA helicase required for the maintenance of chromosomal stability. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. Binds directly to the BRCT domains of BRCA1. Defects in BRIP1 cause of susceptibility to breast cancer and Fanconi anemia. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Belongs to the DEAD box helicase family, DEAH subfamily. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.13; Helicase; EC 3.6.1.-
Cellular Component: nuclear membrane; cytoplasm; nucleus
Molecular Function: ATP-dependent DNA helicase activity; protein binding; DNA binding; metal ion binding; 4 iron, 4 sulfur cluster binding; ATP binding
Biological Process: regulation of transcription from RNA polymerase II promoter; double-strand break repair; DNA damage checkpoint; DNA duplex unwinding
Reference #:  Q9BX63 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent RNA helicase BRIP1; BACH1; BRCA1 interacting protein C-terminal helicase 1; BRCA1-associated C-terminal helicase 1; BRCA1-binding helicase-like protein BACH1; BRCA1-interacting protein 1; BRCA1-interacting protein C-terminal helicase 1; BRIP1; FANCJ; Fanconi anemia group J protein; FLJ90232; MGC126521; MGC126523; OF; Protein FACJ
Gene Symbols: BRIP1
Molecular weight: 140,878 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BRIP1

Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S990‑p, T1133‑p
molecular association, regulation: S990‑p, T1133‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y110-p GTSRHFNyPstPPsE
0 6 S112-p SRHFNyPstPPsERN
0 39 T113-p RHFNyPstPPsERNG
0 1 S116-p NyPstPPsERNGTSS
0 2 S128-p TSSTCQDsPEKTTLA
0 1 T133 QDsPEKTTLAAKLSA
0 4 S197-p GKTVKLNsPLEKINS
0 1 S226-p CSTKQGNsQESSNTI
0 1 K345-u EELVSLGkKLKACPY
0 1 S505-p LQKEEKIsPIYGKEE
0 1 Y742-p FDELLQVyYDAIkYK
0 8 K747-u QVyYDAIkYKGEKDG
0 1 K764-u LVAVCRGkVSEGLDF
0 1 K797-u KDLQVELkRQYNDHH
0 1 K862-u RYISGLSkWVRQQIQ
0 1 S895-p HQKVLNVsIKDRTNI
0 1 Y916-p LEVTSLKyStPPYLL
0 3 T918-p VTSLKyStPPYLLEA
0 1 S927-p PYLLEAAsHLsPENF
0 6 S930-p LEAAsHLsPENFVED
0 3 S956-p PKIITKNsPLPSSII
5 3 S990-p IVISRSTsPTFNKQT
0 1 S1004-p TKRVSWSsFNSLGQY
0 1 S1031-p GSSENSAssPPRFKT
0 4 S1032-p SSENSAssPPRFKTE
0 3 T1045-p TEKMESKtVLPFTDK
0 2 S1106 LDPDIELSLVSEEDK
1 1 T1133-p EDESIYFtPELYDPE
0 4 S1237-p EIKNFKPsPsKNKGM
0 7 S1239-p KNFKPsPsKNKGMFP
1 1 K1249-a KGMFPGFk_______
11983 : Phospho-BACH1/BRIP1 (Thr1133) Antibody
  mouse

 
S110 DTSPHFNSPSKPSSG
S112 SPHFNSPSKPSSGRN
K113 PHFNSPSKPSSGRNG
S116 NSPSKPSSGRNGVST
S128 VSTPCQDSPEKNTLA
T133 QDSPEKNTLAAKLSA
S197-p EKRVKPEsPIGKSFS
N229 CSAKQGNNQEPANTV
R348 EELVSLGRKLKACPY
T508 LQKEEKVTPIHGKEE
Y745 FDELLQVYYDAIkFK
K750-u QVYYDAIkFKGEKDG
K767 LIAVCRGKVSEGLDF
K800 KDLQVELKRQYNDHH
K865 RYISGLSKWVRQQIQ
S898 HQKVTNRSKKDEKCT
- gap
T921 VACLEDSTFTSVSES
S929 FTSVSESSHQSPENS
S932 VSESSHQSPENSTEE
S958 QVATKSPSVASHGVS
S994 NEISRSSSPTFGKQT
- gap
S1037 SKNRAPGSSTFNKTA
S1038 KNRAPGSSTFNKTAL
T1043 GSSTFNKTALPLTGN
S1103-p LLPDTELsPGTEEAK
T1130 DDDSECFTPELFDPV
- gap
- gap
- gap
  rat

 
S110 DTSPHFSSPSKPSSE
S112 SPHFSSPSKPSSERN
K113 PHFSSPSKPSSERNA
S116 SSPSKPSSERNAVSS
S128 VSSPCRDSPERNsLA
S133-p RDSPERNsLAAKLSA
S195 EKRVKPESPIRKTSS
N223 CSANQGINKESANTV
R342 EELVSLGRKLKACPY
T502 LQKEEKVTSTHGKEE
Y739 FDELLQVYYDAIKFK
K744 QVYYDAIKFKGEKDG
K761 LIAVCRGKVSEGLDF
K794 KDLQVELKRQYNDHH
K859 RYISGLSKWVRQQIQ
S892 HQKVTNRSKKEEKCT
- gap
T915 VACLEGSTLTSVSEA
S923 LTSVSEASHQTPENS
T926 VSEASHQTPENSLEE
S953 QMAAENPSGPSHGVS
S989 SEISRSSSPTFGKQT
- gap
S1032 SKNHASASSAFNKTA
S1033 KNHASASSAFNKTAL
T1038 ASSAFNKTALPLTGK
S1095 PSPDAELSPVTEEAK
T1122 DDDSVCFTPELFDPV
- gap
- gap
- gap
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