Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
BRIP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
BRIP1 a DNA-dependent ATPase and DNA helicase required for the maintenance of chromosomal stability. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. Binds directly to the BRCT domains of BRCA1. Defects in BRIP1 cause of susceptibility to breast cancer and Fanconi anemia. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Belongs to the DEAD box helicase family, DEAH subfamily. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.13; EC 3.6.1.-; Helicase
Cellular Component: nuclear membrane; cytoplasm; nucleus
Molecular Function: ATP-dependent DNA helicase activity; protein binding; DNA binding; metal ion binding; 4 iron, 4 sulfur cluster binding; ATP binding
Biological Process: regulation of transcription from RNA polymerase II promoter; ATP catabolic process; double-strand break repair; DNA damage checkpoint; DNA duplex unwinding
Reference #:  Q9BX63 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent RNA helicase BRIP1; BACH1; BRCA1 interacting protein C-terminal helicase 1; BRCA1-associated C-terminal helicase 1; BRCA1-binding helicase-like protein BACH1; BRCA1-interacting protein 1; BRCA1-interacting protein C-terminal helicase 1; BRIP1; FANCJ; Fanconi anemia group J protein; FLJ90232; MGC126521; MGC126523; OF; Protein FACJ
Gene Symbols: BRIP1
Molecular weight: 140,878 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BRIP1

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
cell cycle regulation: S990‑p, T1133‑p
molecular association, regulation: S990‑p, T1133‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y22-p IYFPYKAyPSQLAMM
0 1 S77-p KPADEGVsEKAEVQL
0 1 Y110-p GTSRHFNyPstPPsE
0 6 S112-p SRHFNyPstPPsERN
0 39 T113-p RHFNyPstPPsERNG
0 1 S116-p NyPstPPsERNGTSS
0 1 T124-p ERNGTSStCQDsPEK
0 3 S128-p TSStCQDsPEKTTLA
0 1 T133 QDsPEKTTLAAKLsA
0 2 S139-p TTLAAKLsAKKQASI
0 1 K186-ac EVHNLDAkVDSGkTV
0 1 K191-ac DAkVDSGkTVKLNsP
0 4 S197-p GkTVKLNsPLEKINs
0 1 S204-p sPLEKINsFsPQKPP
0 1 S206-p LEKINsFsPQKPPGH
0 1 S226-p CSTKQGNsQEssNtI
0 1 S229-p KQGNsQEssNtIKKD
0 1 S230-p QGNsQEssNtIKKDH
0 1 T232-p NsQEssNtIKKDHTG
0 1 T274-p AYSGVPMtILSsRDH
0 1 S278-p VPMtILSsRDHTCVH
0 1 K345-ub EELVSLGkKLKACPY
0 1 Y461-p EYLVERDyESACKIW
0 1 S505-p LQKEEKIsPIyGKEE
0 1 Y508-p EEKIsPIyGKEEARE
0 1 T584-p KKRSRQKtAVHVLNF
0 1 Y742-p FDELLQVyYDAIkYK
0 8 K747-ub QVyYDAIkYKGEKDG
0 1 K752 AIkYKGEKDGALLVA
0 1 K764-ub LVAVCRGkVSEGLDF
0 1 K797-ub KDLQVELkRQYNDHH
0 1 K862-ub RYISGLSkWVRQQIQ
0 1 S895-p HQKVLNVsIKDRTNI
0 2 Y916-p LEVTSLKyStPPyLL
0 3 T918-p VTSLKyStPPyLLEA
0 1 Y921-p LKyStPPyLLEAAsH
0 1 S927-p PyLLEAAsHLsPENF
0 7 S930-p LEAAsHLsPENFVED
0 1 T953-p LQCPKIItKNsPLPS
0 5 S956-p PKIItKNsPLPSSII
0 1 S988-p EKIVISRsTsPTFNK
5 6 S990-p IVISRsTsPTFNKQT
0 2 S1001-p NKQTKRVsWSsFNsL
0 2 S1004-p TKRVsWSsFNsLGQY
0 1 S1007-p VsWSsFNsLGQYFTG
0 1 T1020-p TGKIPKAtPELGSSE
0 1 S1031-p GSSENSAssPPRFKT
0 7 S1032-p SSENSAssPPRFKTE
0 3 T1045-p TEKMESKtVLPFtDK
0 1 T1050-p SKtVLPFtDKCESSN
0 1 S1063-p SNLTVNTsFGSCPQS
0 3 S1106 LDPDIELSLVSEEDK
1 1 T1133-p EDESIYFtPELYDPE
0 2 T1142-p ELYDPEDtDEEKNDL
0 2 S1162-p GNRLANNsDCILAkD
0 1 K1168-ac NsDCILAkDLFEIRT
0 6 S1237-p EIKNFKPsPsKNKGM
0 7 S1239-p KNFKPsPsKNKGMFP
1 1 K1249-ac KGMFPGFk_______
11983 : Phospho-BACH1/BRIP1 (Thr1133) Antibody
  mouse

 
Y22 IHFPCRAYPAQLAMM
N77 KPVDEGLNKKPEAPP
S110 DTSPHFNSPSKPSSG
S112 SPHFNSPSKPSSGRN
K113 PHFNSPSKPSSGRNG
S116 NSPSKPSSGRNGVST
P124 GRNGVSTPCQDSPEK
S128 VSTPCQDSPEKNTLA
T133 QDSPEKNTLAAKLSA
S139 NTLAAKLSAKKQASI
R186 DVHHVDARLASEKRV
K191 DARLASEKRVKPEsP
S197-p EKRVKPEsPIGKSFS
S204 sPIGKSFSDRKDSFQ
S209 SFSDRKDSFQNVDGL
N229 CSAKQGNNQEPANTV
P232 KQGNNQEPANTVKKD
A233 QGNNQEPANTVKKDH
T235 NNQEPANTVKKDHGG
T277 AYSGVPMTILSSRDH
S281 VPMTILSSRDHSCVH
R348 EELVSLGRKLKACPY
Y464 KHLVERGYESSCKIW
T508 LQKEEKVTPIHGKEE
H511 EEKVTPIHGKEEAIQ
I587 KKHSRQKIGVNALNF
Y745 FDELLQVYYDAIkFK
K750-ub QVYYDAIkFKGEkDG
K755-ub AIkFKGEkDGALLIA
K767 LIAVCRGKVSEGLDF
K800 KDLQVELKRQYNDHH
K865 RYISGLSKWVRQQIQ
S898 HQKVTNRSKKDEKCT
- gap
T921 VACLEDSTFTSVSES
S924 LEDSTFTSVSESSHQ
S929 FTSVSESSHQSPENS
S932 VSESSHQSPENSTEE
T954 LQCPQVATKSPSVAS
S958 QVATKSPSVASHGVS
S992 EKNEISRSSSPTFGK
S994 NEISRSSSPTFGKQT
- gap
- gap
S1011 VNWPIFNSLRRHFNS
T1024 NSKVKNCTPVLKSSK
S1037 SKNRAPGSSTFNKTA
S1038 KNRAPGSSTFNKTAL
T1043 GSSTFNKTALPLTGN
T1048 NKTALPLTGNCVPSN
S1061 SNETADTSLGPCLQS
S1103-p LLPDTELsPGTEEAK
T1130 DDDSECFTPELFDPV
T1139 ELFDPVDTNEENGEL
S1156 TDRSSHSSDCFSAEE
- gap
- gap
- gap
- gap
  rat

 
Y22 IHFPCRAYPAQLAMM
- under review  
S110 DTSPHFSSPSKPSSE
S112 SPHFSSPSKPSSERN
K113 PHFSSPSKPSSERNA
S116 SSPSKPSSERNAVSS
P124 ERNAVSSPCRDSPER
S128 VSSPCRDSPERNsLA
S133-p RDSPERNsLAAKLSA
S139 NsLAAKLSAKKHASI
R184 DVHHLDARLASEKRV
K189 DARLASEKRVKPESP
S195 EKRVKPESPIRKTSS
S202 SPIRKTSSSFQNPDG
S203 PIRKTSSSFQNPDGL
N223 CSANQGINKESANTV
S226 NQGINKESANTVKKD
A227 QGINKESANTVKKDN
T229 INKESANTVKKDNGD
T271 AYSGVPMTILSSRDH
S275 VPMTILSSRDHTCVH
R342 EELVSLGRKLKACPY
Y458 KNLVERDYESSCKIW
T502 LQKEEKVTSTHGKEE
H505 EEKVTSTHGKEEAIQ
I581 KKHSRQKIGVNVLNF
Y739 FDELLQVYYDAIKFK
K744 QVYYDAIKFKGEKDG
K749 AIKFKGEKDGALLIA
K761 LIAVCRGKVSEGLDF
K794 KDLQVELKRQYNDHH
K859 RYISGLSKWVRQQIQ
S892 HQKVTNRSKKEEKCT
- gap
T915 VACLEGSTLTSVSEA
S918 LEGSTLTSVSEASHQ
S923 LTSVSEASHQTPENS
T926 VSEASHQTPENSLEE
- gap
S953 QMAAENPSGPSHGVS
S987 EKSEISRSSSPTFGK
S989 SEISRSSSPTFGKQT
- gap
- gap
S1006 VNWPIFNSLKRHFNS
T1019 NSKVKNRTPVLKSSK
S1032 SKNHASASSAFNKTA
S1033 KNHASASSAFNKTAL
T1038 ASSAFNKTALPLTGK
T1043 NKTALPLTGKCVSSS
- gap
S1095-p PSPDAELsPVTEEAK
T1122 DDDSVCFTPELFDPV
T1131 ELFDPVSTDEENSEL
S1148 TDRSSNNSDCLSAEE
- gap
- gap
- gap
- gap
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.