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Protein Page:
BRIP1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
BRIP1 a DNA-dependent ATPase and DNA helicase required for the maintenance of chromosomal stability. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. Binds directly to the BRCT domains of BRCA1. Defects in BRIP1 cause of susceptibility to breast cancer and Fanconi anemia. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Belongs to the DEAD box helicase family, DEAH subfamily. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.1.-; Helicase; EC 3.6.4.13
Cellular Component: nuclear membrane; cytoplasm; nucleus
Molecular Function: ATP-dependent DNA helicase activity; protein binding; DNA binding; 4 iron, 4 sulfur cluster binding; metal ion binding; ATP binding
Biological Process: regulation of transcription from RNA polymerase II promoter; double-strand break repair; DNA damage checkpoint
Reference #:  Q9BX63 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent RNA helicase BRIP1; BACH1; BRCA1 interacting protein C-terminal helicase 1; BRCA1-associated C-terminal helicase 1; BRCA1-binding helicase-like protein BACH1; BRCA1-interacting protein 1; BRCA1-interacting protein C-terminal helicase 1; BRIP1; FANCJ; Fanconi anemia group J protein; FLJ90232; MGC126521; MGC126523; OF; Protein FACJ
Gene Symbols: BRIP1
Molecular weight: 140,878 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

BRIP1
Protein Structure Not Found.


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Sites Implicated In
cell cycle regulation: S990‑p, T1133‑p
molecular association, regulation: S990‑p, T1133‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 1 Y22-p IYFPYKAyPSQLAMM
0 4 S112-p SRHFNYPstPPSERN
0 38 T113-p RHFNYPstPPSERNG
0 2 S128-p TSSTCQDsPEKTTLA
0 1 S139-p TTLAAKLsAKKQASI
0 1 K186-a EVHNLDAkVDSGkTV
0 1 K191-a DAkVDSGkTVKLNsP
0 2 S197-p GkTVKLNsPLEKINs
0 1 S204-p sPLEKINsFSPQKPP
0 1 S226-p CSTKQGNsQEssNtI
0 1 S229-p KQGNsQEssNtIKKD
0 1 S230-p QGNsQEssNtIKKDH
0 1 T232-p NsQEssNtIKKDHTG
0 1 T274-p AYSGVPMtILSSRDH
0 1 K345-u EELVSLGkKLKACPY
0 1 Y461-p EYLVERDyESACKIW
0 1 Y508-p EEKISPIyGKEEARE
0 1 Y742-p FDELLQVyYDAIkYK
0 8 K747-u QVyYDAIkYKGEKDG
0 1 K752 AIkYKGEKDGALLVA
0 1 K764-u LVAVCRGkVSEGLDF
0 1 K797-u KDLQVELkRQYNDHH
0 1 K862-u RYISGLSkWVRQQIQ
0 1 Y916-p LEVTSLKyStPPYLL
0 3 T918-p VTSLKyStPPYLLEA
0 1 S927-p PYLLEAAsHLsPENF
0 6 S930-p LEAAsHLsPENFVED
0 2 S956-p PKIITKNsPLPSSII
5 2 S990-p IVISRSTsPTFNKQT
0 1 S1007-p VSWSSFNsLGQYFTG
0 1 S1031-p GSSENSAssPPRFKT
0 3 S1032-p SSENSAssPPRFKTE
0 3 T1045-p TEKMESKtVLPFtDK
0 1 T1050-p SKtVLPFtDKCESSN
0 2 S1106 LDPDIELSLVSEEDK
1 1 T1133-p EDESIYFtPELYDPE
0 1 K1168-a NSDCILAkDLFEIRT
0 4 S1237-p EIKNFKPsPsKNKGM
0 7 S1239-p KNFKPsPsKNKGMFP
1 1 K1249-a KGMFPGFk_______
11983 : Phospho-BACH1/BRIP1 (Thr1133) Antibody
  mouse

 
Y22 IHFPCRAYPAQLAMM
S112 SPHFNSPSKPSSGRN
K113 PHFNSPSKPSSGRNG
S128 VSTPCQDSPEKNTLA
S139 NTLAAKLSAKKQASI
R186 DVHHVDARLASEKRV
K191 DARLASEKRVKPEsP
S197-p EKRVKPEsPIGKSFS
S202 PEsPIGKSFSDRKDS
N229 CSAKQGNNQEPANTV
P232 KQGNNQEPANTVKKD
A233 QGNNQEPANTVKKDH
T235 NNQEPANTVKKDHGG
T277 AYSGVPMTILSSRDH
R348 EELVSLGRKLKACPY
Y464 KHLVERGYESSCKIW
H511 EEKVTPIHGKEEAIQ
Y745 FDELLQVYYDAIkFK
K750-u QVYYDAIkFKGEkDG
K755-u AIkFKGEkDGALLIA
K767 LIAVCRGKVSEGLDF
K800 KDLQVELKRQYNDHH
K865 RYISGLSKWVRQQIQ
D919 LEVACLEDSTFTSVS
T921 VACLEDSTFTSVSES
S929 FTSVSESSHQSPENS
S932 VSESSHQSPENSTEE
S956 CPQVATKSPSVASHG
S994 NEISRSSSPTFGKQT
S1011 VNWPIFNSLRRHFNS
S1037 SKNRAPGSSTFNKTA
S1038 KNRAPGSSTFNKTAL
T1043 GSSTFNKTALPLTGN
T1048 NKTALPLTGNCVPSN
S1103-p LLPDTELsPGTEEAK
T1130 DDDSECFTPELFDPV
- gap
- gap
- gap
- gap
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