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PTCH2 (human)

Overview PTCH2 May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH). Belongs to the patched family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral Cellular Component: integral to membrane Molecular Function: hedgehog receptor activity; smoothened binding Biological Process: skin development; negative regulation of smoothened signaling pathway; hair cycle Reference #:  Q9Y6C5 (UniProtKB) Alt. Names/Synonyms: patched homolog 2 (Drosophila); Protein patched homolog 2; PTC2; PTCH2 Gene Symbols: PTCH2 Molecular weight: 130,544 Da Basal Isoelectric point: 6  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PTCH2

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  DISEASE 155255 603673 605462  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T2-p	______MtRsPPLRE
0	1		S4-p	____MtRsPPLRELP
0	1		T15-p	RELPPSYtPPARTAA
0	1		K162-a	DLNKICYkSGVPLIE
0	1		K179-a	MIERMIEkLFPCVIL
0	1		K197-a	DCFWEGAkLQGGSAY
0	16		T775-p	AVLPPPAtQAPRTWL
0	1		S1194-p	ATSSGNLsSRGPGPA

	mouse
V2	______MVRPLSLGE
P4	____MVRPLSLGELP
T15	GELPPSYTPPARSSA
K162	DLNKICYKSGVPLIE
K179	MIERMIEKLFPCVIL
K197	DCFWEGAKLQGGSAY
T775-p	AVLPPPAtQAPRTWL
-	gap

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