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Protein Page:
XRCC1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
XRCC1 Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; damaged DNA binding
Biological Process: response to organic substance; response to drug; single strand break repair; base-excision repair; hippocampus development; response to hypoxia; DNA repair
Reference #:  P18887 (UniProtKB)
Alt. Names/Synonyms: DNA repair protein XRCC1; RCC; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross complementing protein 1; X-ray repair cross-complementing protein 1; X-ray-repair, complementing defective, repair in Chinese hamster; XRCC1
Gene Symbols: XRCC1
Molecular weight: 69,477 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

XRCC1

Protein Structure Not Found.


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Sites Implicated In
cell growth, altered: T284‑p
activity, induced: T284‑p
intracellular localization: S475‑p, S485‑p, T488‑p, S518‑p, T519‑p, T523‑p, S525‑p
molecular association, regulation: T284‑p, S371‑p, S475‑p, S485‑p, T488‑p, S518‑p, T519‑p, T523‑p, S525‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S140-p SQPYSKDsPFGLSFV
0 2 K169-ac SQKVTVTkLGQFRVK
0 1 K169-ub SQKVTVTkLGQFRVK
1 0 S184-p EEDESANsLRPGALF
0 2 T198-p FFSRINKtsPVtAsD
0 6 S199-p FSRINKtsPVtAsDP
0 3 T202-p INKtsPVtAsDPAGP
0 1 S204-p KtsPVtAsDPAGPsy
1 0 S210-p AsDPAGPsyAAATLQ
0 1 Y211-p sDPAGPsyAAATLQA
1 11 S226-p SSAASSAsPVsRAIG
1 2 S229-p ASSAsPVsRAIGsts
0 1 S234-p PVsRAIGstsKPQEs
0 1 T235-p VsRAIGstsKPQEsP
0 2 S236-p sRAIGstsKPQEsPK
0 16 S241-p stsKPQEsPKGKRKL
0 2 K256-ac DLNQEEKktPskPPA
0 4 T257-p LNQEEKktPskPPAQ
0 1 S259-p QEEKktPskPPAQLs
0 2 K260-ac EEKktPskPPAQLsP
0 1 - gap
0 6 S266-p skPPAQLsPsVPkRP
0 4 S268-p PPAQLsPsVPkRPKL
0 2 K271-ac QLsPsVPkRPKLPAP
0 1 T281-p KLPAPTRtPAtAPVP
1 1 T284-p APTRtPAtAPVPARA
0 1 T296-p ARAQGAVtGkPRGEG
0 1 T296-ga ARAQGAVtGkPRGEG
0 7 K298-ac AQGAVtGkPRGEGTE
0 1 Y370-p AFANTPKysQVLGLG
1 1 S371-p FANTPKysQVLGLGG
0 2 S408-p YLMAGPGsssEEDEA
0 2 S409-p LMAGPGsssEEDEAs
0 2 S410-p MAGPGsssEEDEAsH
0 2 S416-p ssEEDEAsHsGGsGD
0 1 S418-p EEDEAsHsGGsGDEA
0 2 S421-p EAsHsGGsGDEAPKL
0 1 T437-p QKQPQTKtKPtQAAG
0 5 T440-p PQTKtKPtQAAGPss
0 1 T440-ga PQTKtKPtQAAGPss
0 10 S446-p PtQAAGPssPQKPPt
0 1 S446-ga PtQAAGPssPQKPPt
0 33 S447-p tQAAGPssPQKPPtP
0 1 S447-ga tQAAGPssPQKPPtP
0 53 T453-p ssPQKPPtPEEtKAA
0 1 T453-ga ssPQKPPtPEEtKAA
0 7 T457-p KPPtPEEtKAAsPVL
1 6 S461-p PEEtKAAsPVLQEDI
0 1 - gap
0 1 - gap
2 2 S475-p IDIEGVQsEGQDNGA
2 8 S485-p QDNGAEDsGDtEDEL
2 9 T488-p GAEDsGDtEDELRRV
2 8 S518-p GEDPYAGstDENtDs
2 7 T519-p EDPYAGstDENtDsE
2 5 T523-p AGstDENtDsEEHQE
1 4 S525-p stDENtDsEEHQEPP
0 1 - gap
0 2 Y627-p KLLPHQLyGVVPQA_
  mouse

 
S142 SQPYSKDSPYGLSFV
K171 SQKVTVTKLGQFRVK
K171 SQKVTVTKLGQFRVK
S186 EEDDSANSLKPGALF
T200 FFSRINKTSSASTSD
S201 FSRINKTSSASTSDP
S204 INKTSSASTSDPAGP
S206 KTSSASTSDPAGPSY
S212 TSDPAGPSYAAATLQ
Y213 SDPAGPSYAAATLQA
S228-p SSAASSAsPVPKVVG
- gap
S236 PVPKVVGSSSKPQEP
S237 VPKVVGSSSKPQEPP
S238 PKVVGSSSKPQEPPK
- gap
K258 DLSLEDRKPPSKPsA
- gap
S261 LEDRKPPSKPsAGPS
K262 EDRKPPSKPsAGPST
S264-p RKPPSKPsAGPSTLK
- gap
S268 SKPsAGPSTLKRPKL
K271 sAGPSTLKRPKLSVP
T281 KLSVPSRTPAAAPAS
- gap
P296 TPAQRAVPGKPRGEG
- gap
K298 AQRAVPGKPRGEGTE
Y370 AFANTPKYSQVLGLG
S371 FANTPKYSQVLGLGG
S408 YLMAGLGSSSEDEGD
S409 LMAGLGSSSEDEGDS
S410 MAGLGSSSEDEGDSH
S416 SSEDEGDSHSESGED
S418 EDEGDSHSESGEDEA
G421 GDSHSESGEDEAPKL
A437 QKRPQPKAKTQAAGP
T439 RPQPKAKTQAAGPss
T439 RPQPKAKTQAAGPss
S445-p KTQAAGPssPPRPPt
S445 KTQAAGPSsPPRPPt
S446-p TQAAGPssPPRPPtP
S446 TQAAGPsSPPRPPtP
T452-p ssPPRPPtPKETKAP
T452 ssPPRPPTPKETKAP
T456 RPPtPKETKAPSPGP
S460 PKETKAPSPGPQDNs
S467-p SPGPQDNsDtEGEES
T469-p GPQDNsDtEGEESEG
S474 sDtEGEESEGRDNGA
S484-p RDNGAEDsGDtEDEL
T487-p GAEDsGDtEDELRRV
S517-p GEDPYAGstDENTDs
T518-p EDPYAGstDENTDsE
T522 AGstDENTDsEtPSE
S524-p stDENTDsEtPSEAD
T526-p DENTDsEtPSEADLP
Y625 KLLPHQLYGVVPQA_
  rat

 
S142 SQPYSKDSPYGLSFV
K171 SQKVTVTKLGQFRVK
K171 SQKVTVTKLGQFRVK
S186 EEDDSANSLRPGALF
- gap
- gap
S204 INKAASASASDPAGP
S206 KAASASASDPAGPSY
S212 ASDPAGPSYAAATLQ
Y213 SDPAGPSYAAATLQA
S228 SSAASSASPVPKVGG
- gap
S236 PVPKVGGSSSKLQEP
S237 VPKVGGSSSKLQEPP
S238 PKVGGSSSKLQEPPK
- gap
K258 DLGLEDKKPPSKPSA
- gap
S261 LEDKKPPSKPSAGPP
K262 EDKKPPSKPSAGPPA
S264 KKPPSKPSAGPPAPK
- gap
- gap
K271 SAGPPAPKRPKLPVP
T281 KLPVPSRTPAATPAS
- gap
P296 TPAQKAVPGKPRGEG
- gap
K298 AQKAVPGKPRGEGTE
Y370 AFANTPKYSQVLGLG
S371 FANTPKYSQVLGLGG
S408 YLMAGLGSSSEDEGD
S409 LMAGLGSSSEDEGDS
S410 MAGLGSSSEDEGDSH
S416 SSEDEGDSHSESGED
S418 EDEGDSHSESGEDEA
G421 GDSHSESGEDEAPKL
A437 RKRPQPKAKTQAAGP
T439 RPQPKAKTQAAGPSS
T439 RPQPKAKTQAAGPSS
S445 KTQAAGPSSPPRPPT
S445 KTQAAGPSSPPRPPT
S446 TQAAGPSSPPRPPTP
S446 TQAAGPSSPPRPPTP
T452 SSPPRPPTPEETKAP
T452 SSPPRPPTPEETKAP
T456 RPPTPEETKAPSPGP
S460 PEETKAPSPGPQDNS
S467 SPGPQDNSDTDGEQS
T469 GPQDNSDTDGEQSEG
S474 SDTDGEQSEGRDNGA
S484 RDNGAEDSGDTEDEL
T487 GAEDSGDTEDELRRV
S517 GEDPYAGSTDENTDS
T518 EDPYAGSTDENTDSE
T522 AGSTDENTDSEAPSE
S524 STDENTDSEAPSEAD
- gap
Y625 KLLPHQLYGVVPQA_
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