Home

XRCC1 (human)

Overview XRCC1 Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1. Note: This description may include information from UniProtKB. Protein type: DNA repair Cellular Component: nucleoplasm; nucleus Molecular Function: protein binding; damaged DNA binding Biological Process: response to organic substance; response to drug; single strand break repair; base-excision repair; response to hypoxia; DNA repair Reference #:  P18887 (UniProtKB) Alt. Names/Synonyms: DNA repair protein XRCC1; RCC; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross complementing protein 1; X-ray repair cross-complementing protein 1; X-ray-repair, complementing defective, repair in Chinese hamster; XRCC1 Gene Symbols: XRCC1 Molecular weight: 69,477 Da Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below XRCC1 1CDZ - A=538-633 (human) 1XNA - A=1-183 (human) 1XNT - A=1-183 (human) 2D8M - A=306-422 (human) 2W3O - D/C=515-522 (human) 3K75 - C/B=1-183 (human) 3K77 - F/A/E/B/H/C/D/G=1-155 (human) 3LQC - A=1-183 (human) 3PC6 - A/B=535-631 (mouse) 3PC8 - A/B=534-631 (mouse) 3QVG - D/B=531-631 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cell growth, altered: T284‑p activation: T284‑p intracellular localization: S475‑p, S485‑p, T488‑p, S518‑p, T519‑p, T523‑p, S525‑p molecular association, regulation: T284‑p, S371‑p, S475‑p, S485‑p, T488‑p, S518‑p, T519‑p, T523‑p, S525‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		S140-p	SQPYSKDsPFGLSFV
0	1		K169-a	SQKVTVTkLGQFRVK
0	1		K169-u	SQKVTVTkLGQFRVK
1	0		S184-p	EEDESANsLRPGALF
0	2		T198-p	FFSRINKtsPVtAsD
0	5		S199-p	FSRINKtsPVtAsDP
0	3		T202-p	INKtsPVtAsDPAGP
0	1		S204-p	KtsPVtAsDPAGPsy
1	0		S210-p	AsDPAGPsyAAATLQ
0	1		Y211-p	sDPAGPsyAAATLQA
1	8		S226-p	SSAASSAsPVsRAIG
1	2		S229-p	ASSAsPVsRAIGSts
0	1		T235-p	VsRAIGStsKPQEsP
0	1		S236-p	sRAIGStsKPQEsPK
0	11		S241-p	StsKPQEsPKGKRKL
1	2		K256-a	DLNQEEKktPskPPA
0	3		T257-p	LNQEEKktPskPPAQ
0	1		S259-p	QEEKktPskPPAQLs
1	2		K260-a	EEKktPskPPAQLsP
0	1		P262	KktPskPPAQLsPsV
0	2		S266-p	skPPAQLsPsVPkRP
0	3		S268-p	PPAQLsPsVPkRPKL
1	2		K271-a	QLsPsVPkRPKLPAP
1	0		T284-p	APTRTPAtAPVPARA
0	1		T296-ga	ARAQGAVtGkPRGEG
0	6		K298-a	AQGAVtGkPRGEGTE
0	1		Y370-p	AFANTPKysQVLGLG
1	1		S371-p	FANTPKysQVLGLGG
0	2		S408-p	YLMAGPGsssEEDEA
0	2		S409-p	LMAGPGsssEEDEAs
0	2		S410-p	MAGPGsssEEDEAsH
0	1		S416-p	ssEEDEAsHsGGsGD
0	1		S418-p	EEDEAsHsGGsGDEA
0	2		S421-p	EAsHsGGsGDEAPKL
0	2		T440-p	PQTKTKPtQAAGPss
0	1		T440-ga	PQTKTKPtQAAGPss
0	7		S446-p	PtQAAGPssPQKPPt
0	1		S446-ga	PtQAAGPssPQKPPt
0	27		S447-p	tQAAGPssPQKPPtP
0	1		S447-ga	tQAAGPssPQKPPtP
0	45		T453-p	ssPQKPPtPEEtKAA
0	1		T453-ga	ssPQKPPtPEEtKAA
0	4		T457-p	KPPtPEEtKAAsPVL
1	3		S461-p	PEEtKAAsPVLQEDI
0	1		I468	sPVLQEDIDIEGVQs
0	1		I470	VLQEDIDIEGVQsEG
2	2		S475-p	IDIEGVQsEGQDNGA
2	6		S485-p	QDNGAEDsGDtEDEL
2	8		T488-p	GAEDsGDtEDELRRV
2	8		S518-p	GEDPYAGstDENtDs
2	7		T519-p	EDPYAGstDENtDsE
2	5		T523-p	AGstDENtDsEEHQE
1	4		S525-p	stDENtDsEEHQEPP
0	1		E527	DENtDsEEHQEPPDL
0	2		Y627-p	KLLPHQLyGVVPQA_

	XRCC1 var1
S140	SQPYSKDSPFGLSFV
K169	SQKVTVTKLGQFRVK
K169	SQKVTVTKLGQFRVK
S184	EEDESANSLRPGALF
T198	FFSRINKTSPVTASD
S199	FSRINKTSPVTASDP
T202	INKTSPVTASDPAGP
S204	KTSPVTASDPAGPSY
S210	ASDPAGPSYAAATLQ
Y211	SDPAGPSYAAATLQA
S226	SSAASSASPVSRAIG
S229	ASSASPVSRAIGSTS
T235	VSRAIGSTSKPQESP
S236	SRAIGSTSKPQESPK
S241	STSKPQESPKGKRKL
K256	DLNQEEKKTPSKPPA
T257	LNQEEKKTPSKPPAQ
S259	QEEKKTPSKPPAQLS
K260	EEKKTPSKPPAQLSP
P262	KKTPSKPPAQLSPSV
S266	SKPPAQLSPSVPKRP
S268	PPAQLSPSVPKRPKL
K271	QLSPSVPKRPKLPAP
T284	APTRTPATAPVPARA
T296	ARAQGAVTGKPRGEG
K298	AQGAVTGKPRGEGTE
Y370	AFANTPKYSQVLGLG
S371	FANTPKYSQVLGLGG
S408	YLMAGPGSSSEEDEA
S409	LMAGPGSSSEEDEAS
S410	MAGPGSSSEEDEASH
S416	SSEEDEASHSGGSGD
S418	EEDEASHSGGSGDEA
S421	EASHSGGSGDEAPKL
T440	PQTKTKPTQAAGPSS
T440	PQTKTKPTQAAGPSS
S446	PTQAAGPSSPQKPPT
S446	PTQAAGPSSPQKPPT
S447	TQAAGPSSPQKPPTP
S447	TQAAGPSSPQKPPTP
T453	SSPQKPPTPEETKAA
T453	SSPQKPPTPEETKAA
T457	KPPTPEETKAASPVL
S461	PEETKAASPVLQEDI
I468	SPVLQEDIDIEGVQS
I470	VLQEDIDIEGVQSEG
S475	IDIEGVQSEGQDNGA
S485	QDNGAEDSGDTEDEL
T488	GAEDSGDTEDELRRV
S518	GEDPYAGSTDENTDS
T519	EDPYAGSTDENTDSE
T523	AGSTDENTDSEEHQE
S525	STDENTDSEEHQEPP
E527	DENTDSEEHQEPPDL
Y627	KLLPHQLYGVVPQA_

	mouse
S142	SQPYSKDSPYGLSFV
K171	SQKVTVTKLGQFRVK
K171	SQKVTVTKLGQFRVK
S186	EEDDSANSLKPGALF
T200	FFSRINKTSSASTSD
S201	FSRINKTSSASTSDP
S204	INKTSSASTSDPAGP
S206	KTSSASTSDPAGPSY
S212	TSDPAGPSYAAATLQ
Y213	SDPAGPSYAAATLQA
S228-p	SSAASSAsPVPKVVG
P231	ASSAsPVPKVVGSSS
S237	VPKVVGSSSKPQEPP
S238	PKVVGSSSKPQEPPK
P243	SSSKPQEPPKGKRKL
K258	DLSLEDRKPPSKPsA
P259	LSLEDRKPPSKPsAG
S261	LEDRKPPSKPsAGPS
K262	EDRKPPSKPsAGPST
S264-p	RKPPSKPsAGPSTLK
-	gap
S268	SKPsAGPSTLKRPKL
K271	sAGPSTLKRPKLSVP
A284	VPSRTPAAAPASTPA
P296	TPAQRAVPGKPRGEG
K298	AQRAVPGKPRGEGTE
Y370	AFANTPKYSQVLGLG
S371	FANTPKYSQVLGLGG
S408	YLMAGLGSSSEDEGD
S409	LMAGLGSSSEDEGDS
S410	MAGLGSSSEDEGDSH
S416	SSEDEGDSHSESGED
S418	EDEGDSHSESGEDEA
G421	GDSHSESGEDEAPKL
T439	RPQPKAKTQAAGPss
T439	RPQPKAKTQAAGPss
S445-p	KTQAAGPssPPRPPt
S445	KTQAAGPSsPPRPPt
S446-p	TQAAGPssPPRPPtP
S446	TQAAGPsSPPRPPtP
T452-p	ssPPRPPtPKETKAP
T452	ssPPRPPTPKETKAP
T456	RPPtPKETKAPSPGP
S460	PKETKAPSPGPQDNs
S467-p	SPGPQDNsDtEGEES
T469-p	GPQDNsDtEGEESEG
S474	sDtEGEESEGRDNGA
S484-p	RDNGAEDsGDtEDEL
T487-p	GAEDsGDtEDELRRV
S517-p	GEDPYAGstDENTDs
T518-p	EDPYAGstDENTDsE
T522	AGstDENTDsEtPSE
S524-p	stDENTDsEtPSEAD
T526-p	DENTDsEtPSEADLP
Y625	KLLPHQLYGVVPQA_

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.