Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; damaged DNA binding
Biological Process: response to drug; response to organic substance; single strand break repair; base-excision repair; hippocampus development; response to hypoxia; DNA repair
Alt. Names/Synonyms: DNA repair protein XRCC1; RCC; X-ray repair complementing defective repair in Chinese hamster cells 1; X-ray repair cross complementing protein 1; X-ray repair cross-complementing protein 1; X-ray-repair, complementing defective, repair in Chinese hamster; XRCC1
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.