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Protein Page:
EPCAM (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EPCAM a single-pass type I membrane protein of the EPCAM family. May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinomas including pancreatic carcinoma. May be a marker of cancer stem cells. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral
Cellular Component: cell surface; tight junction; basolateral plasma membrane; apical plasma membrane; integral to membrane; plasma membrane; lateral plasma membrane
Molecular Function: protein binding; protein complex binding
Biological Process: ureteric bud development; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; stem cell differentiation
Reference #:  P16422 (UniProtKB)
Alt. Names/Synonyms: ACSTD1; Adenocarcinoma-associated antigen; carcinoma-associated antigen GA733-2; Cell surface glycoprotein Trop-1; CO-17A; CO17-1A; DIAR5; EGP; EGP-2; EGP314; EGP34; EGP40; Ep-CAM; EPCAM; Epithelial cell adhesion molecule; Epithelial cell surface antigen; Epithelial glycoprotein; Epithelial glycoprotein 314; ESA; GA733-2; hEGP-2; hEGP314; HNPCC8; human epithelial glycoprotein-2; KS 1/4 antigen; KS1/4; KSA; M1S2; M4S1; Major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein); MIC18; MK-1; TACST-1; TACSTD1; TROP1; Tumor-associated calcium signal transducer 1
Gene Symbols: EPCAM
Molecular weight: 34,932 Da
Basal Isoelectric point: 7.42  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

EPCAM

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K168-ub SLRTALQkEIttRYQ
0 1 T171-ga TALQkEIttRYQLDP
0 1 T172-ga ALQkEIttRYQLDPK
0 1 K218-ub DVAYYFEkDVKGESL
0 1 Y297-p RKKRMAKyEkAEIkE
0 6 K299-ub KRMAKyEkAEIkEMG
0 11 K303-ub KyEkAEIkEMGEMHR
  mouse

 
E168 SLQTALQEAFTSRYK
T171 TALQEAFTSRYKLNQ
S172 ALQEAFTSRYKLNQK
K218 DVAYYFEKDVKGESL
Y298 TRKKSAKYEKAEIkE
K300 KKSAKYEKAEIkEMG
K304-ub KYEKAEIkEMGEIHR
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