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CD44
Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Cell adhesion |
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Cellular Component: Golgi apparatus; cell surface; protein complex; membrane; basolateral plasma membrane; apical plasma membrane; cytoplasm; integral to membrane; plasma membrane; nucleus; external side of plasma membrane
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Molecular Function: protein binding; transmembrane receptor activity; cytokine binding; hyaluronic acid binding; phosphoprotein binding; protein kinase binding; hyalurononglucosaminidase activity; epidermal growth factor receptor binding
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Biological Process: cell migration; Wnt receptor signaling pathway; positive regulation of heterotypic cell-cell adhesion; positive regulation of neutrophil apoptosis; negative regulation of caspase activity; positive regulation of peptidyl-serine phosphorylation; hyaluronan catabolic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of mature B cell apoptosis; ureteric bud branching; regulation of cell growth; cell adhesion; healing during inflammatory response; neurite development; positive regulation of adaptive immune response; negative regulation of apoptosis
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Reference #:
P15379 (UniProtKB)
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| Alt. Names/Synonyms: AU023126; AW121933; AW146109; Cd44; CD44 antigen; ECMR-III; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; HERMES; Hermes antigen; HUTCH-I; Hyaluronate receptor; Ly-24; Lymphocyte antigen 24; OTTMUSP00000015733; OTTMUSP00000015734; OTTMUSP00000015735; PGP-1; PGP-I; Phagocytic glycoprotein 1; Phagocytic glycoprotein I |
| Gene Symbols: Cd44 |
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Molecular weight: 85,617 Da
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Basal Isoelectric point: 4.82
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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