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Protein Page:
CD44 (mouse)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CD44 Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Interacts with PKN2. Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. 19 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Receptor, misc.; Cell adhesion
Cellular Component: protein complex; cell surface; membrane; basolateral plasma membrane; apical plasma membrane; integral to membrane; plasma membrane; nucleus; external side of plasma membrane
Molecular Function: protein binding; transmembrane receptor activity; cytokine binding; hyaluronic acid binding; phosphoprotein binding; protein kinase binding; epidermal growth factor receptor binding; hyalurononglucosaminidase activity
Biological Process: cell migration; positive regulation of heterotypic cell-cell adhesion; Wnt receptor signaling pathway; positive regulation of neutrophil apoptosis; negative regulation of caspase activity; positive regulation of peptidyl-serine phosphorylation; hyaluronan catabolic process; negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of mature B cell apoptosis; ureteric bud branching; regulation of cell growth; cell adhesion; healing during inflammatory response; positive regulation of adaptive immune response; neurite development; negative regulation of apoptosis
Reference #:  P15379 (UniProtKB)
Alt. Names/Synonyms: AU023126; AW121933; AW146109; Cd44; CD44 antigen; ECMR-III; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; HERMES; Hermes antigen; HUTCH-I; Hyaluronate receptor; Ly-24; Lymphocyte antigen 24; OTTMUSP00000015733; OTTMUSP00000015734; OTTMUSP00000015735; PGP-1; PGP-I; Phagocytic glycoprotein 1; Phagocytic glycoprotein I
Gene Symbols: Cd44
Molecular weight: 85,617 Da
Basal Isoelectric point: 4.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CD44

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Source  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

► Hide Isoforms
 
0 2 T64-p AFNSTLPtMDQMKLA
0 1 I177 DIDASNIIDDDVSSG
0 1 T186 DDVSSGSTIEKSTPE
0 1 T199 PEGYILHTYLPTEQP
0 1 - gap
0 1 T203 ILHTYLPTEQPTGDQ
0 1 T356 TPRVSARTEDNQDWT
0 1 T363 TEDNQDWTQWKPNHS
0 1 N368 DWTQWKPNHSNPEVL
0 1 S370 TQWKPNHSNPEVLLQ
0 1 N447 QNGWQGKNPPTPSED
0 1 V457 TPSEDSHVTEGTTAS
0 1 T458 PSEDSHVTEGTTASA
0 1 - gap
0 1 T461 DSHVTEGTTASAHNN
0 1 S464 VTEGTTASAHNNHPS
0 1 - gap
0 1 - gap
0 1 S492 TDFFDPISHPMGQGH
0 1 S547 QSHSQNFSTLHGEPE
0 1 T548 SHSQNFSTLHGEPEE
0 1 T561 EEDENYPTTSILPSS
0 1 T562 EDENYPTTSILPSST
0 1 K574 SSTKSSAKDARRGGS
0 1 T584 RRGGSLPTDTTTSVE
0 1 T586 GGSLPTDTTTSVEGY
0 1 T587 GSLPTDTTTSVEGYT
0 1 T588 SLPTDTTTSVEGYTF
0 1 Y593 TTTSVEGYTFQYPDT
0 1 T594 TTSVEGYTFQYPDTM
0 1 F595 TSVEGYTFQYPDTME
0 1 T600 YTFQYPDTMENGTLF
0 1 N603 QYPDTMENGTLFPVT
0 1 T605 PDTMENGTLFPVTPA
0 1 T610 NGTLFPVTPAKTEVF
0 1 P611 GTLFPVTPAKTEVFG
0 1 T614 FPVTPAKTEVFGETE
0 1 V616 VTPAKTEVFGETEVT
2 0 S708 AVCIAVNSRRRCGQK
0 7 K717 RRCGQKKKLVINGGN
0 8 G722 KKKLVINGGNGtVED
0 7 T726-p VINGGNGtVEDRKPs
0 1 K731 NGtVEDRKPsELNGE
1 28 S733-p tVEDRKPsELNGEAs
3 12 S740-p sELNGEAsKsQEMVH
0 7 K741 ELNGEAsKsQEMVHL
10 51 S742-p LNGEAsKsQEMVHLV
0 13 K751-u EMVHLVNkEPsEtPD
0 2 S754-p HLVNkEPsEtPDQCM
0 4 T756-p VNkEPsEtPDQCMTA
0 3 T762 EtPDQCMTADETRNL
0 1 S771-p DETRNLQsVDMKIGV
0 41 K775 NLQsVDMKIGV____
  CD44 iso2  
T64 AFNSTLPTMDQMKLA
I177 DIDASNIIDDDVSSG
T186 DDVSSGSTIEKSTPE
T199 PEGYILHTYLPTEQP
- gap
T203 ILHTYLPTEQPTGDQ
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S293 AVCIAVNSRRRCGQK
K302 RRCGQKKKLVINGGN
G307 KKKLVINGGNGTVED
T311 VINGGNGTVEDRKPS
K316 NGTVEDRKPSELNGE
S318 TVEDRKPSELNGEAs
S325-p SELNGEAsKsQEMVH
K326 ELNGEAsKsQEMVHL
S327-p LNGEAsKsQEMVHLV
K336 EMVHLVNKEPSETPD
S339 HLVNKEPSETPDQCM
T341 VNKEPSETPDQCMTA
T347 ETPDQCMTADETRNL
S356 DETRNLQSVDMKIGV
K360 NLQSVDMKIGV____
  human

► Hide Isoforms
 
T62-p AFNSTLPtMAQMEKA
T174-ga DIYPSNPtDDDVSSG
S183-p DDVSSGSsSERSSTS
T197-ga SGGYIFYtFstVHPI
S199-ga GYIFYtFstVHPIPD
T200-ga YIFYtFstVHPIPDE
T318-ga TPRAFDHtKQNQDWt
T325-ga tKQNQDWtQWNPsHs
S330-ga DWtQWNPsHsNPEVL
S332-ga tQWNPsHsNPEVLLQ
Y412-ga GNRWHEGyRQTPKED
S422-ga TPKEDSHsttGtAAA
T423-ga PKEDSHsttGtAAAs
T424-ga KEDSHsttGtAAAsA
T426-ga DSHsttGtAAAsAHt
S430-ga ttGtAAAsAHtsHPM
T433-ga tAAAsAHtsHPMQGR
S434-ga AAAsAHtsHPMQGRT
S458-ga TDFFNPIsHPMGRGH
S514-ga QSNSQSFstSHEGLE
T515-ga SNSQSFstSHEGLEE
T528-ga EEDKDHPttSTLTSS
T529-ga EDKDHPttSTLTSSN
T541-ga SSNRNDVtGGRRDPN
S550-ga GRRDPNHsEGsttLL
S553-ga DPNHsEGsttLLEGy
T554-ga PNHsEGsttLLEGyt
T555-ga NHsEGsttLLEGyts
Y560-ga sttLLEGytsHYPHt
T561-ga ttLLEGytsHYPHtK
S562-ga tLLEGytsHYPHtKE
T567-ga ytsHYPHtKEsRtFI
S570-ga HYPHtKEsRtFIPVt
T572-ga PHtKEsRtFIPVtsA
T577-ga sRtFIPVtsAKtGsF
S578-ga RtFIPVtsAKtGsFG
T581-ga IPVtsAKtGsFGVTA
S583-ga VtsAKtGsFGVTAVT
S672-p AVCIAVNsRRRCGQK
K681-u RRCGQKKkLVINsGN
S686-p KKkLVINsGNGAVED
A690 VINsGNGAVEDRkPs
K695-u NGAVEDRkPsGLNGE
S697-p AVEDRkPsGLNGEAs
S704-p sGLNGEAsksQEMVH
K705-u GLNGEAsksQEMVHL
S706-p LNGEAsksQEMVHLV
K715-u EMVHLVNkESsEtPD
S718-p HLVNkESsEtPDQFM
T720-p VNkESsEtPDQFMtA
T726-p EtPDQFMtADETRNL
N735 DETRNLQNVDMkIGV
K739-u NLQNVDMkIGV____
  CD44 iso30  
T62 AFNSTLPTMAQMEKA
T174 DIYPSNPTDDDVSSG
S183 DDVSSGSSSERSSTS
T197 SGGYIFYTFSTVHPI
S199 GYIFYTFSTVHPIPD
T200 YIFYTFSTVHPIPDE
T318 TPRAFDHTKQNQDWT
T325 TKQNQDWTQWNPSHS
S330 DWTQWNPSHSNPEVL
S332 TQWNPSHSNPEVLLQ
Y412 GNRWHEGYRQTPKED
S422 TPKEDSHSTTGTAAA
T423 PKEDSHSTTGTAAAS
T424 KEDSHSTTGTAAASA
T426 DSHSTTGTAAASAHT
S430 TTGTAAASAHTSHPM
T433 TAAASAHTSHPMQGR
S434 AAASAHTSHPMQGRT
S458 TDFFNPISHPMGRGH
S514 QSNSQSFSTSHEGLE
T515 SNSQSFSTSHEGLEE
T528 EEDKDHPTTSTLTSS
T529 EDKDHPTTSTLTSSN
T541 SSNRNDVTGGRRDPN
S550 GRRDPNHSEGSTTLL
S553 DPNHSEGSTTLLEGY
T554 PNHSEGSTTLLEGYT
T555 NHSEGSTTLLEGYTS
Y560 STTLLEGYTSHYPHT
T561 TTLLEGYTSHYPHTK
S562 TLLEGYTSHYPHTKE
T567 YTSHYPHTKESRTFI
S570 HYPHTKESRTFIPVT
T572 PHTKESRTFIPVTSA
T577 SRTFIPVTSAKTGSF
S578 RTFIPVTSAKTGSFG
T581 IPVTSAKTGSFGVTA
S583 VTSAKTGSFGVTAVT
S672 AVCIAVNSRRRCGQK
K681 RRCGQKKKLVINSGN
S686 KKKLVINSGNGAVED
A690 VINSGNGAVEDRKPS
K695 NGAVEDRKPSGLNGE
S697 AVEDRKPSGLNGEAS
S704 SGLNGEASKSQEMVH
K705 GLNGEASKSQEMVHL
S706 LNGEASKSQEMVHLV
K715 EMVHLVNKESSETPD
S718 HLVNKESSETPDQFM
T720 VNKESSETPDQFMTA
T726 ETPDQFMTADETRNL
N735 DETRNLQNVDMKIGV
K739 NLQNVDMKIGV____
  rat

 
T65 AFNTTLPTMAQMELA
I178 DIDASNIIDEDVSSG
T187 EDVSSGSTIEKSTPE
T200 PEGYILHTDLPTSQP
- gap
T204 ILHTDLPTSQPTGDR
T234 TPWVSAHTKQNQERT
T241 TKQNQERTQWNPIHS
I246 ERTQWNPIHSNPEVL
S248 TQWNPIHSNPEVLLQ
N328 ENEWQGKNPPTPSED
V338 TPSEDSHVTEGTTAS
T339 PSEDSHVTEGTTASA
- gap
T342 DSHVTEGTTASAHNN
S345 VTEGTTASAHNNHPS
- gap
- gap
S373 TDFFDPISHPMGQGH
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S433 AVCIAVNSRRRCGQK
K442 RRCGQKKKLVINsGN
S447-p KKKLVINsGNGtVED
T451-p VINsGNGtVEDRKPs
K456 NGtVEDRKPsELNGE
S458-p tVEDRKPsELNGEAS
S465 sELNGEASKSQEMVH
K466 ELNGEASKSQEMVHL
S467 LNGEASKSQEMVHLV
K476 EMVHLVNKEPTETPD
T479 HLVNKEPTETPDQFM
T481 VNKEPTETPDQFMTA
T487 ETPDQFMTADETRNL
S496 DETRNLQSVDMKIGV
K500 NLQSVDMKIGV____
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