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Protein Page:
Claudin-1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Claudin-1 Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Acts as a co- receptor for HCV entry into hepatic cells. Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL. May interact with HCV E1 and E2 proteins. Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. Belongs to the claudin family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cytoskeletal protein; Membrane protein, multi-pass
Cellular Component: tight junction; integral to plasma membrane; apical plasma membrane; integral to membrane; lateral plasma membrane
Molecular Function: identical protein binding; protein binding; structural molecule activity
Biological Process: intercellular junction assembly and maintenance; viral reproduction; cell adhesion; calcium-independent cell-cell adhesion
Reference #:  O95832 (UniProtKB)
Alt. Names/Synonyms: claudin 1; Claudin-1; claudin1; CLD1; CLDN1; ILVASC; SEMP1; Senescence-associated epithelial membrane protein; senescence-associated epithelial membrane protein 1
Gene Symbols: CLDN1
Molecular weight: 22,744 Da
Basal Isoelectric point: 8.41  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Claudin-1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 T191-gl CSCPRKTtsYPtPRP
1 0 S192-gl SCPRKTtsYPtPRPY
0 4 T195-p RKTtsYPtPRPYPKP
1 0 A203 PRPYPKPAPssGkDy
0 1 S205 PYPKPAPSsGkDyV_
1 0 S205-gl PYPKPAPssGkDyV_
1 2 S206-p YPKPAPssGkDyV__
1 0 S206-gl YPKPAPssGkDyV__
0 2 K208-ub KPAPssGkDyV____
0 134 Y210-p APssGkDyV______
  mouse

 
T191 CSCPRKTTSYPTPRP
S192 SCPRKTTSYPTPRPY
T195 RKTTSYPTPRPYPKP
T203-p PRPYPKPtPssGKDY
S205-p PYPKPtPssGKDYV_
S205 PYPKPtPSsGKDYV_
S206-p YPKPtPssGKDYV__
S206 YPKPtPsSGKDYV__
K208 KPtPssGKDYV____
Y210 tPssGKDYV______
  rat

 
T191 CSCPRKTTSYPTPRP
S192 SCPRKTTSYPTPRPY
T195 RKTTSYPTPRPYPKP
T203 PRPYPKPTPSSGKDY
S205 PYPKPTPSSGKDYV_
S205 PYPKPTPSSGKDYV_
S206 YPKPTPSSGKDYV__
S206 YPKPTPSSGKDYV__
K208 KPTPSSGKDYV____
Y210 TPSSGKDYV______
  chicken

 
T191 CSCPRSETSYPPSRG
S192 SCPRSETSYPPSRGY
P195 RSETSYPPSRGYPKN
A203 SRGYPKNAPStGKDY
S205 GYPKNAPStGKDYV_
S205 GYPKNAPStGKDYV_
T206-p YPKNAPStGKDYV__
T206 YPKNAPSTGKDYV__
K208 KNAPStGKDYV____
Y210 APStGKDYV______
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