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claudin 1 (human)

Overview claudin 1 Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Acts as a co- receptor for HCV entry into hepatic cells. Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN2, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with MPDZ and INADL. May interact with HCV E1 and E2 proteins. Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. Belongs to the claudin family. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Cytoskeletal protein Cellular Component: tight junction; integral to plasma membrane; integral to membrane; lateral plasma membrane Molecular Function: identical protein binding; structural molecule activity Biological Process: intercellular junction assembly and maintenance; virus-host interaction; cell adhesion; calcium-independent cell-cell adhesion Reference #:  O95832 (UniProtKB) Alt. Names/Synonyms: claudin 1; Claudin-1; CLD1; CLDN1; ILVASC; SEMP1; Senescence-associated epithelial membrane protein; senescence-associated epithelial membrane protein 1 Gene Symbols: CLDN1 Molecular weight: 22,744 Da Basal Isoelectric point: 8.41  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below claudin 1

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 603718 607626  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S192-p	SCPRKTTsYPtPRPY
0	5		T195-p	RKTTsYPtPRPYPKP
1	0		A203	PRPYPKPAPSsGkDy
0	1		S205	PYPKPAPSsGkDyV_
1	2		S206-p	YPKPAPSsGkDyV__
0	2		K208-u	KPAPSsGkDyV____
0	143		Y210-p	APSsGkDyV______

	mouse
S192	SCPRKTTSYPTPRPY
T195	RKTTSYPTPRPYPKP
T203-p	PRPYPKPtPssGKDY
S205-p	PYPKPtPssGKDYV_
S206-p	YPKPtPssGKDYV__
K208	KPtPssGKDYV____
Y210	tPssGKDYV______

	rat
S192	SCPRKTTSYPTPRPY
T195	RKTTSYPTPRPYPKP
T203	PRPYPKPTPSSGKDY
S205	PYPKPTPSSGKDYV_
S206	YPKPTPSSGKDYV__
K208	KPTPSSGKDYV____
Y210	TPSSGKDYV______

	chicken
S192	SCPRSETSYPPSRGY
P195	RSETSYPPSRGYPKN
A203	SRGYPKNAPStGKDY
S205	GYPKNAPStGKDYV_
T206-p	YPKNAPStGKDYV__
K208	KNAPStGKDYV____
Y210	APStGKDYV______

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