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Protein Page:
REL (human)

Overview
REL a proto-oncogenic transcription factor of the nuclear factor-kappaB (NFkB) group. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. May play a role in differentiation and lymphopoiesis. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Cellular Component: nucleoplasm; transcription factor complex; cytosol
Molecular Function: protein binding; transcription factor activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 biosynthetic process; transcription, DNA-dependent; cytokine production; positive regulation of transcription from RNA polymerase II promoter
Reference #:  Q04864 (UniProtKB)
Alt. Names/Synonyms: C-Rel; C-Rel proto-oncogene protein; oncogene REL, avian reticuloendotheliosis; Proto-oncogene c-Rel; REL; v-rel avian reticuloendotheliosis viral oncogene homolog; v-rel reticuloendotheliosis viral oncogene homolog (avian)
Gene Symbols: REL
Molecular weight: 68,520 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

REL

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: S503‑p
transcription, altered: S503‑p, S557‑p
transcription, induced: S492‑p, S503‑p, S523‑p, S526‑p
activity, induced: S492‑p, S523‑p, S526‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S3-p _____MAsGAyNPYI
0 1 Y6-p __MAsGAyNPYIEII
0 4 Y47-p STDNNRTyPSIQIMN
0 1 Y88-p GKDCRDGyyEAEFGQ
0 1 Y89-p KDCRDGyyEAEFGQE
0 1 Y176-p PVVSNPIyDNRAPNT
0 1 Y359-p GSIGEGRyFKKEPNL
0 1 S386-p GVSSQAEsyYPSPGP
0 3 Y387-p VSSQAEsyYPSPGPI
0 1 T433-p NPLSSFStRtLPSNS
0 2 T435-p LSSFStRtLPSNSQG
0 1 S479 MEASSMPSADLYGIS
2 0 S492-p ISDPNMLsNCSVNMM
2 0 S503-p VNMMTTSsDSMGETD
1 0 S523-p SMNLENPsCNsVLDP
1 0 S526-p LENPsCNsVLDPRDL
1 0 S557-p SNTTVFVsQSDAFEG
0 1 Y597-p GFVQDSQySGIGSMQ
  mouse

 
S3 _____MASSGYNPYV
Y6 __MASSGYNPYVEII
Y47 STDNNRTYPSVQIMN
Y88 GKDCRDGYYEAEFGP
Y89 KDCRDGYYEAEFGPE
Y176 PIVSNPIYDNRAPNT
F327 GSTGEGRFIKKESNL
P356 GVPGQAEPYYSSCGS
Y357 VPGQAEPYYSSCGSI
A406 NTLSTFSAGTLSSNS
T408 LSTFSAGTLSSNSQG
S450-p RMETPSMsPTDLYSI
S464 ISDVNMLSTRPLSVM
T475 LSVMAPSTDGMGDTD
S495 SINLENPSCNARLGP
A498 LENPSCNARLGPRDL
S528 SSSSVFVSQSDAFDR
Y566 TFVQSSHYSVNTLQS
  rat

 
S3 _____ILSGGYNPYV
Y6 __ILSGGYNPYVEII
Y47 STDNNRTYPSIQIMN
Y88 GKDCRDGYYEAEFGP
Y89 KDCRDGYYEAEFGPE
Y176 PIVSNPIYDNRAPNT
F327 ESIGETRFIKKESNL
P356 GVPGQAEPYYSSSGS
Y357 VPGQAEPYYSSSGSI
A406 NTLSSFPAGQLSSNS
Q408 LSSFPAGQLSSNSQG
S450 RMETPSMSPTDLYSI
T464 ISDVNMLTNRPVSVM
T475 VSVMTSSTDGMGDTD
S495 SVNLENPSCNSRLDP
S498 LENPSCNSRLDPRDP
S529 SSSSVFVSQSDTFNR
Y567 NFAQSSQYSGIDALQ
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