Home

REL (human)

Overview REL a proto-oncogenic transcription factor of the nuclear factor-kappaB (NFkB) group. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. May play a role in differentiation and lymphopoiesis. Note: This description may include information from UniProtKB. Protein type: Transcription factor Cellular Component: nucleoplasm; cytosol Molecular Function: protein binding; DNA binding; transcription factor activity Biological Process: positive regulation of interleukin-12 biosynthetic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; cytokine production Reference #:  Q04864 (UniProtKB) Alt. Names/Synonyms: C-Rel; C-Rel proto-oncogene protein; oncogene REL, avian reticuloendotheliosis; Proto-oncogene c-Rel; REL; v-rel avian reticuloendotheliosis viral oncogene homolog; v-rel reticuloendotheliosis viral oncogene homolog (avian) Gene Symbols: REL Molecular weight: 68,520 Da Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states CST Pathways:  Apoptosis  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below REL

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Sites Implicated In
apoptosis, altered: S503‑p transcription, altered: S492‑p, S503‑p, S523‑p, S526‑p, S557‑p activation: S492‑p, S523‑p, S526‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y6-p	__MASGAyNPYIEII
0	4		Y47-p	STDNNRTyPSIQIMN
0	1		Y88-p	GKDCRDGyyEAEFGQ
0	1		Y89-p	KDCRDGyyEAEFGQE
0	1		Y176-p	PVVSNPIyDNRAPNT
0	1		Y359-p	GSIGEGRyFKKEPNL
0	1		S386-p	GVSSQAEsyYPSPGP
0	3		Y387-p	VSSQAEsyYPSPGPI
2	0		S492-p	ISDPNMLsNCSVNMM
2	0		S503-p	VNMMTTSsDSMGETD
1	0		S523-p	SMNLENPsCNsVLDP
1	0		S526-p	LENPsCNsVLDPRDL
1	0		S557-p	SNTTVFVsQSDAFEG
0	3		Y597-p	GFVQDSQySGIGSMQ

	mouse
Y6	__MASSGYNPYVEII
Y47	STDNNRTYPSVQIMN
Y88	GKDCRDGYYEAEFGP
Y89	KDCRDGYYEAEFGPE
Y176	PIVSNPIYDNRAPNT
F327	GSTGEGRFIKKESNL
P356	GVPGQAEPYYSSCGS
Y357	VPGQAEPYYSSCGSI
S464	ISDVNMLSTRPLSVM
T475	LSVMAPSTDGMGDTD
S495	SINLENPSCNARLGP
A498	LENPSCNARLGPRDL
S528	SSSSVFVSQSDAFDR
Y566	TFVQSSHYSSVNTLQ

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.