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Protein Page:
REL (human)

Overview
REL a proto-oncogenic transcription factor of the nuclear factor-kappaB (NFkB) group. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. May play a role in differentiation and lymphopoiesis. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Cellular Component: nucleoplasm; transcription factor complex; cytosol
Molecular Function: protein binding; transcription factor activity
Biological Process: I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 biosynthetic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; cytokine production; positive regulation of transcription from RNA polymerase II promoter
Reference #:  Q04864 (UniProtKB)
Alt. Names/Synonyms: C-Rel; C-Rel proto-oncogene protein; oncogene REL, avian reticuloendotheliosis; Proto-oncogene c-Rel; REL; v-rel avian reticuloendotheliosis viral oncogene homolog; v-rel reticuloendotheliosis viral oncogene homolog (avian)
Gene Symbols: REL
Molecular weight: 68,520 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

REL

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: S503‑p
transcription, altered: S503‑p, S557‑p
transcription, induced: S492‑p, S503‑p, S523‑p, S526‑p
activity, induced: S492‑p, S523‑p, S526‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S3-p _____MAsGAyNPYI
0 1 Y6-p __MAsGAyNPYIEII
0 4 Y47-p STDNNRTyPSIQIMN
0 1 Y88-p GKDCRDGyyEAEFGQ
0 1 Y89-p KDCRDGyyEAEFGQE
0 1 Y176-p PVVSNPIyDNRAPNT
0 1 Y359-p GSIGEGRyFKKEPNL
0 1 S386-p GVSSQAEsyYPSPGP
0 3 Y387-p VSSQAEsyYPSPGPI
0 1 S479 MEASSMPSADLYGIS
2 0 S492-p ISDPNMLsNCSVNMM
2 0 S503-p VNMMTTSsDSMGETD
1 0 S523-p SMNLENPsCNsVLDP
1 0 S526-p LENPsCNsVLDPRDL
1 0 S557-p SNTTVFVsQSDAFEG
0 1 Y597-p GFVQDSQySGIGSMQ
  mouse

 
S3 _____MASSGYNPYV
Y6 __MASSGYNPYVEII
Y47 STDNNRTYPSVQIMN
Y88 GKDCRDGYYEAEFGP
Y89 KDCRDGYYEAEFGPE
Y176 PIVSNPIYDNRAPNT
F327 GSTGEGRFIKKESNL
P356 GVPGQAEPYYSSCGS
Y357 VPGQAEPYYSSCGSI
S450-p RMETPSMsPTDLYSI
S464 ISDVNMLSTRPLSVM
T475 LSVMAPSTDGMGDTD
S495 SINLENPSCNARLGP
A498 LENPSCNARLGPRDL
S528 SSSSVFVSQSDAFDR
Y566 TFVQSSHYSVNTLQS
  rat

 
S3 _____ILSGGYNPYV
Y6 __ILSGGYNPYVEII
Y47 STDNNRTYPSIQIMN
Y88 GKDCRDGYYEAEFGP
Y89 KDCRDGYYEAEFGPE
Y176 PIVSNPIYDNRAPNT
F327 ESIGETRFIKKESNL
P356 GVPGQAEPYYSSSGS
Y357 VPGQAEPYYSSSGSI
S450 RMETPSMSPTDLYSI
T464 ISDVNMLTNRPVSVM
T475 VSVMTSSTDGMGDTD
S495 SVNLENPSCNSRLDP
S498 LENPSCNSRLDPRDP
S529 SSSSVFVSQSDTFNR
Y567 NFAQSSQYSGIDALQ
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