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Protein Page:
VDR (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
VDR Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. Defects in VDR are the cause of rickets vitamin D- dependent type 2A (VDDR2A). A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets. Belongs to the nuclear hormone receptor family. NR1 subfamily. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Nuclear receptor; DNA binding protein
Cellular Component: nucleoplasm; nucleus
Molecular Function: retinoid X receptor binding; protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; vitamin D3 receptor activity; transcription factor activity
Biological Process: lactation; transcription initiation from RNA polymerase II promoter; positive regulation of apoptosis involved in mammary gland involution; cell morphogenesis; decidualization; negative regulation of transcription from RNA polymerase II promoter; signal transduction; intestinal absorption; cellular calcium ion homeostasis; negative regulation of cell proliferation; organ morphogenesis; calcium ion transport; gene expression; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; skeletal development; positive regulation of keratinocyte differentiation
Reference #:  P11473 (UniProtKB)
Alt. Names/Synonyms: 1,25-dihydroxyvitamin D3 receptor; NR1I1; Nuclear receptor subfamily 1 group I member 1; VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor; Vitamin D3 receptor
Gene Symbols: VDR
Molecular weight: 48,289 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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VDR

Protein Structure Not Found.


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Sites Implicated In
transcription, altered: S208‑p
transcription, induced: S51‑p, S208‑p
transcription, inhibited: S182‑p
molecular association, regulation: S182‑p, S208‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 0 S51-p CKGFFRRsMKRKALF
1 0 S172-p SHPSRPNsRHtPSFS
1 0 T175-p SRPNsRHtPSFSGDs
1 0 S182-p tPSFSGDsSSSCSDH
3 0 S208-p SFSNLDLsEEDSDDP
0 1 K302-u YRVSDVTkAGHSLEL
  mouse

 
S51 CKGFFRRSMKRKALF
- gap
T171 GSYSPRPTLSFSGDS
S178 TLSFSGDSSSNSDLY
N203 SFSTMDLNEEGSDDP
R297 YDITDVSRAGHTLEL
  rat

 
S51 CKGFFRRSMKRKALF
- gap
T171 GSYSPRPTLSFSGNS
S178 TLSFSGNSSSSSSDL
N204 GFSNLDLNGEDSDDP
K298 YDVTDVSKAGHTLEL
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