|
LIF
LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes. Belongs to the LIF/OSM family. Note: This description may include information from UniProtKB.
|
| Protein type: Secreted; Secreted, signal peptide |
|
Cellular Component: extracellular space; cytoplasm
|
|
Molecular Function: growth factor activity; leukemia inhibitory factor receptor binding; cytokine activity; receptor binding
|
|
Biological Process: maternal process involved in pregnancy; leukemia inhibitory factor signaling pathway; multicellular organismal development; negative regulation of hormone secretion; tyrosine phosphorylation of Stat3 protein; decidualization; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of adrenocorticotropic hormone secretion; negative regulation of cell proliferation; positive regulation of MAPKKK cascade; astrocyte differentiation; negative regulation of meiosis; positive regulation of cell proliferation; positive regulation of macrophage differentiation; muscle morphogenesis; positive regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of astrocyte differentiation; organ regeneration; stem cell maintenance; positive regulation of peptidyl-serine phosphorylation; negative regulation of angiogenesis; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of tyrosine phosphorylation of Stat1 protein; retina development in camera-type eye; neuron development; blood vessel remodeling; immune response; positive regulation of transcription from RNA polymerase II promoter; alveolus development; embryo implantation
|
|
Reference #:
P15018 (UniProtKB)
|
| Alt. Names/Synonyms: CDF; cholinergic differentiation factor; D factor; DIA; differentiation inhibitory activity; differentiation stimulating factor; Differentiation-stimulating factor; HILDA; Leukemia inhibitory factor; leukemia inhibitory factor (cholinergic differentiation factor); LIF; Melanoma-derived LPL inhibitor; MLPLI |
| Gene Symbols: LIF |
|
Molecular weight: 22,008 Da
|
|
Basal Isoelectric point: 9.44
Predict pI for various phosphorylation states
|
