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Protein Page:
LIF (human)

LIF LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes. Belongs to the LIF/OSM family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 22q12.2
Cellular Component: extracellular space; cytoplasm
Molecular Function: growth factor activity; leukemia inhibitory factor receptor binding; cytokine activity; receptor binding
Biological Process: leukemia inhibitory factor signaling pathway; negative regulation of hormone secretion; multicellular organismal development; tyrosine phosphorylation of Stat3 protein; decidualization; positive regulation of adrenocorticotropic hormone secretion; positive regulation of tyrosine phosphorylation of Stat3 protein; negative regulation of cell proliferation; astrocyte differentiation; positive regulation of MAPKKK cascade; negative regulation of meiosis; positive regulation of cell proliferation; positive regulation of macrophage differentiation; muscle morphogenesis; positive regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of astrocyte differentiation; organ regeneration; stem cell maintenance; stem cell differentiation; positive regulation of peptidyl-serine phosphorylation; negative regulation of angiogenesis; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of peptidyl-tyrosine phosphorylation; retina development in camera-type eye; neuron development; immune response; blood vessel remodeling; positive regulation of transcription from RNA polymerase II promoter; alveolus development; embryo implantation
Reference #:  P15018 (UniProtKB)
Alt. Names/Synonyms: CDF; cholinergic differentiation factor; D factor; DIA; differentiation inhibitory activity; differentiation stimulating factor; Differentiation-stimulating factor; HILDA; Leukemia inhibitory factor; leukemia inhibitory factor (cholinergic differentiation factor); LIF; Melanoma-derived LPL inhibitor; MLPLI
Gene Symbols: LIF
Molecular weight: 22,008 Da
Basal Isoelectric point: 9.44  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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