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G-alpha2(i)
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. Belongs to the G-alpha family. G(i/o/t/z) subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: G protein, heterotrimeric alpha G((i/o/t/z)); G protein, heterotrimeric; G protein |
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Cellular Component: centrosome; extrinsic to internal side of plasma membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex; midbody; cytosol; nucleus; lipid raft
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Molecular Function: GTPase activity; signal transducer activity; protein binding; G-protein-coupled receptor binding; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding
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Biological Process: platelet activation; acetylcholine receptor signaling, muscarinic pathway; activation of MAPKK activity; negative regulation of adenylate cyclase activity; protein kinase cascade; signal transduction; cell cycle; negative regulation of synaptic transmission; synaptic transmission; cell proliferation; G-protein coupled receptor protein signaling pathway; GTP catabolic process; cell division; positive regulation of cell proliferation; G-protein signaling, adenylate cyclase inhibiting pathway; blood coagulation; adenosine receptor signaling pathway; response to nutrient; gamma-aminobutyric acid signaling pathway
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Reference #:
P04899 (UniProtKB)
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| Alt. Names/Synonyms: Adenylate cyclase-inhibiting G alpha protein; GIP; GNAI2; GNAI2B; GTP-binding regulatory protein Gi alpha-2 chain; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; Guanine nucleotide-binding protein G(i) subunit alpha-2; guanine nucleotide-binding protein G(i), alpha-2 subunit; H_LUCA15.1; H_LUCA16.1 |
| Gene Symbols: GNAI2 |
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Molecular weight: 40,451 Da
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Basal Isoelectric point: 5.34
Predict pI for various phosphorylation states
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CST Pathways:
Hedgehog Signaling
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Parkinson's Disease
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Phospholipase Signaling
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PI3K/Akt Signaling
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Regulation of Actin Dynamics
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Regulation of Microtubule Dynamics
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