Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
G-alpha i2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
G-alpha i2 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. Belongs to the G-alpha family. G(i/o/t/z) subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: G protein, heterotrimeric alpha G((i/o/t/z)); G protein; G protein, heterotrimeric
Cellular Component: centrosome; extrinsic to internal side of plasma membrane; cytoplasm; plasma membrane; nucleolus; heterotrimeric G-protein complex; midbody; cytosol; nucleus; lipid raft
Molecular Function: GTPase activity; signal transducer activity; protein binding; G-protein-coupled receptor binding; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding
Biological Process: platelet activation; acetylcholine receptor signaling, muscarinic pathway; activation of MAPKK activity; negative regulation of adenylate cyclase activity; regulation of calcium ion transport; signal transduction; cell cycle; negative regulation of synaptic transmission; cell proliferation; synaptic transmission; G-protein coupled receptor protein signaling pathway; GTP catabolic process; cell division; positive regulation of cell proliferation; G-protein signaling, adenylate cyclase inhibiting pathway; blood coagulation; adenosine receptor signaling pathway; gamma-aminobutyric acid signaling pathway; response to nutrient
Reference #:  P04899 (UniProtKB)
Alt. Names/Synonyms: Adenylate cyclase-inhibiting G alpha protein; GIP; GNAI2; GNAI2B; GTP-binding regulatory protein Gi alpha-2 chain; guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2; Guanine nucleotide-binding protein G(i) subunit alpha-2; guanine nucleotide-binding protein G(i), alpha-2 subunit; H_LUCA15.1; H_LUCA16.1
Gene Symbols: GNAI2
Molecular weight: 40,451 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Hedgehog Signaling  |  Microtubule Dynamics  |  Parkinson's Disease  |  Phospholipase Signaling  |  PI3K/Akt Signaling
Select Structure to View Below

G-alpha i2

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S6 __MGCTVSAEDKAAA
0 1 K10 CTVSAEDKAAAERSK
0 11 K29-ub NLREDGEkAAREVkL
0 2 K35 EkAAREVKLLLLGAG
0 3 K35-ub EkAAREVkLLLLGAG
1 2 S44-p LLLGAGEsGkSTIVk
0 47 K46-ub LGAGEsGkSTIVkQM
0 42 K51-ub sGkSTIVkQMKIIHE
0 89 Y61-p KIIHEDGySEEECRQ
0 22 Y69-p SEEECRQyRAVVYSN
0 1 S75 QyRAVVYSNTIQSIM
2 0 S144-p VQACFGRsREyQLND
0 1 Y147-p CFGRsREyQLNDSAA
0 3 Y155-p QLNDSAAyYLNDLER
0 5 Y168-p ERIAQSDyIPTQQDV
0 6 K181 DVLRTRVKTTGIVET
0 3 K193-ub VETHFTFkDLHFkMF
0 1 K198 TFkDLHFKMFDVGGQ
0 3 K198-ub TFkDLHFkMFDVGGQ
1 2 S207 FDVGGQRSERKKWIH
0 1 K249 NRMHESMKLFDsICN
0 12 K249-ub NRMHESMkLFDsICN
0 2 S253-p ESMkLFDsICNNKWF
0 5 K272 IILFLNKKDLFEEKI
0 15 K296-ub PEYTGANkYDEAAsY
1 0 S302-p NkYDEAAsYIQSkFE
0 3 K307-ub AAsYIQSkFEDLNKR
0 8 K313 SkFEDLNKRKDTKEI
0 2 K346-ub AVTDVIIkNNLkDCG
0 8 K350-ub VIIkNNLkDCGLF__
  mouse

 
S6 __MGCTVSAEDkAAA
K10-ub CTVSAEDkAAAERSK
K29-ub NLREDGEkAAREVkL
K35 EkAAREVKLLLLGAG
K35-ub EkAAREVkLLLLGAG
S44-p LLLGAGEsGkSTIVk
K46-ub LGAGEsGkSTIVkQM
K51-ub sGkSTIVkQMKIIHE
Y61-p KIIHEDGySEEECRQ
Y69-p SEEECRQyRAVVYsN
S75-p QyRAVVYsNTIQSIM
S144 VQACFGRSREYQLND
Y147 CFGRSREYQLNDSAA
Y155 QLNDSAAYYLNDLER
Y168 ERIAQSDYIPTQQDV
K181-ub DVLRTRVkTTGIVET
K193-ub VETHFTFkDLHFkMF
K198 TFkDLHFKMFDVGGQ
K198-ub TFkDLHFkMFDVGGQ
S207-p FDVGGQRsERKKWIH
K249 NRMHESMKLFDsICN
K249-ub NRMHESMkLFDsICN
S253-p ESMkLFDsICNNKWF
K272-ub IILFLNKkDLFEEKI
K296-ub PEYTGANkYDEAASY
S302 NkYDEAASYIQSkFE
K307-ub AASYIQSkFEDLNkR
K313-ub SkFEDLNkRKDTKEI
K346-ub AVTDVIIkNNLkDCG
K350-ub VIIkNNLkDCGLF__
  rat

 
S6-p __MGCTVsAEDKAAA
K10 CTVsAEDKAAAERSK
K29-ub NLREDGEkAAREVkL
K35-ac EkAAREVkLLLLGAG
K35 EkAAREVKLLLLGAG
S44 LLLGAGESGkSTIVk
K46-ub LGAGESGkSTIVkQM
K51-ub SGkSTIVkQMKIIHE
Y61 KIIHEDGYSEEECRQ
Y69 SEEECRQYRAVVYSN
S75 QYRAVVYSNTIQSIM
S144-p VQACFGRsREYQLND
Y147 CFGRsREYQLNDSAA
Y155-p QLNDSAAyYLNDLER
Y168 ERIAQSDYIPTQQDV
K181 DVLRTRVKTTGIVET
K193 VETHFTFKDLHFkMF
K198-ac TFKDLHFkMFDVGGQ
K198 TFKDLHFKMFDVGGQ
S207-p FDVGGQRsERKKWIH
K249-ac NRMHESMkLFDSICN
K249 NRMHESMKLFDSICN
S253 ESMkLFDSICNNKWF
K272 IILFLNKKDLFEEKI
K296 PEYTGANKYDEAASY
S302 NKYDEAASYIQSKFE
K307 AASYIQSKFEDLNKR
K313 SKFEDLNKRKDTKEI
K346 AVTDVIIKNNLKDCG
K350 VIIKNNLKDCGLF__
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.