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FABP4 (human)

Overview FABP4 Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. Homodimer. Interacts with PPARG. Monomer. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. Note: This description may include information from UniProtKB. Protein type: Lipid binding protein Cellular Component: cytoplasm; lipid particle; nucleus Molecular Function: transporter activity; fatty acid binding Biological Process: cholesterol homeostasis; white fat cell differentiation; triacylglycerol catabolic process; brown fat cell differentiation; cytokine production; negative regulation of protein kinase activity; lipid metabolic process; negative regulation of transcription, DNA-dependent; positive regulation of inflammatory response Reference #:  P15090 (UniProtKB) Alt. Names/Synonyms: A-FABP; Adipocyte lipid-binding protein; Adipocyte-type fatty acid-binding protein; AFABP; ALBP; aP2; FABP4; fatty acid binding protein 4, adipocyte; Fatty acid-binding protein 4; Fatty acid-binding protein, adipocyte Gene Symbols: FABP4 Molecular weight: 14,719 Da Basal Isoelectric point: 6.59  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FABP4 1TOU - A=1-132 (human) 1TOW - A=1-132 (human) 2HNX - A=1-132 (human) 2NNQ - A=2-132 (human) 3FR2 - A=2-132 (human) 3FR4 - A=1-132 (human) 3FR5 - A=2-132 (human) 3P6C - A=1-132 (human) 3P6D - A=1-132 (human) 3P6E - A=1-132 (human) 3P6F - A=1-132 (human) 3P6G - A=1-132 (human) 3P6H - A=1-132 (human) 3Q6L - A=1-132 (human) 3RZY - A=1-132 (human) 1A18 - A=1-132 (mouse) 1A2D - A/B=1-132 (mouse) 1AB0 - A=3-132 (mouse) 1ACD - A=3-132 (mouse) 1ADL - A=1-132 (mouse) 1ALB - A=1-132 (mouse) 1G74 - A=1-132 (mouse) 1G7N - A=1-132 (mouse) 1LIB - A=1-132 (mouse) 1LIC - A=1-132 (mouse) 1LID - A=1-132 (mouse) 1LIE - A=1-132 (mouse) 1LIF - A=1-132 (mouse) 2ANS - A/B=1-132 (mouse) 2Q9S - A=1-132 (mouse) 2QM9 - A/B=1-132 (mouse) 3HK1 - A=2-132 (mouse) 3JS1 - A/B=2-132 (mouse) 3JSQ - A=2-132 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1TOU 1TOW 2HNX 2NNQ 3FR2 3FR4 3FR5 3P6C 3P6D 3P6E 3P6F 3P6G 3P6H 3Q6L 3RZY  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S13	VGTWKLVSSENFDDy
2	3		Y20-p	SSENFDDyMKEVGVG
0	4		K22	ENFDDyMKEVGVGFA
0	1		T30	EVGVGFATRKVAGMA
0	1		K32	GVGFATRKVAGMAKP
0	1		K38	RKVAGMAKPNMIISV
0	1		T57	ITIKSESTFKNTEIS
0	2		K59	IKSESTFKNTEISFI
0	1		K59	IKSESTFKNTEISFI
0	2		T75	GQEFDEVTADDRKVK
0	1		K80	EVTADDRKVKSTITL
0	1		K97	GVLVHVQKWDGkStt
0	1		K101-a	HVQKWDGkSttIKRK
0	1		K101	HVQKWDGKSttIKRK
0	1		T103-p	QKWDGkSttIKRKRE
0	1		T104-p	KWDGkSttIKRKRED
0	1		K113	KRKREDDKLVVECVM
0	2		K121	LVVECVMKGVTSTRV
0	3		K121	LVVECVMKGVTSTRV
0	2		Y129-p	GVTSTRVyERA____

	mouse
S13-p	VGTWKLVsSENFDDy
Y20-p	sSENFDDyMkEVGVG
K22-u	ENFDDyMkEVGVGFA
T30-p	EVGVGFAtRkVAGMA
K32-u	GVGFAtRkVAGMAkP
K38-u	RkVAGMAkPNMIISV
T57-p	VTIRSEStFkNTEIS
K59-a	IRSEStFkNTEISFK
K59-u	IRSEStFkNTEISFK
T75-p	GVEFDEItADDRkVK
K80-u	EItADDRkVKSIITL
K97-u	GALVQVQkWDGkSTT
K101	QVQkWDGKSTTIKRK
K101-u	QVQkWDGkSTTIKRK
T103	QkWDGkSTTIKRKRD
T104	kWDGkSTTIKRKRDG
K113-u	KRKRDGDkLVVECVM
K121-a	LVVECVMkGVTSTRV
K121-u	LVVECVMkGVTSTRV
Y129	GVTSTRVYERA____

	rat
S13	VGTWKLVSSENFDDY
Y20	SSENFDDYMKEVGVG
K22	ENFDDYMKEVGVGFA
T30	EVGVGFATRKVAGMA
K32	GVGFATRKVAGMAKP
K38	RKVAGMAKPNLIISV
T57	VVIRSESTFKNTEIS
K59	IRSESTFKNTEISFK
K59	IRSESTFKNTEISFK
T75	GVEFDEITPDDRKVK
K80	EITPDDRKVKSIITL
K97	GVLVHVQKWDGKSTT
K101	HVQKWDGKSTTIKKR
K101	HVQKWDGKSTTIKKR
T103	QKWDGKSTTIKKRRD
T104	KWDGKSTTIKKRRDG
K113	KKRRDGDKLVVECVM
K121	LVVECVMKGVTSTRV
K121	LVVECVMKGVTSTRV
Y129	GVTSTRVYERA____

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