a guanine nucleotide exchange factor that activates Ras by catalyzing the exchange of bound GDP for GTP. Interacts with GRB2, NCK, and other adapter proteins. Plays an important role in signaling pathways leading from the G-protein- coupled receptors and receptor tyrosine kinases to MAPK/ERK. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; GEFs, Ras; Motility/polarity/chemotaxis; GEFs
Molecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; DNA binding; protein heterodimerization activity; SH3 domain binding; GTPase activator activity; Ras guanyl-nucleotide exchange factor activity
Biological Process: epidermal growth factor receptor signaling pathway; platelet activation; axon guidance; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; activation of MAPKK activity; positive regulation of apoptosis; regulation of T cell differentiation in the thymus; regulation of T cell proliferation; MAPKKK cascade; signal transduction; positive regulation of small GTPase mediated signal transduction; regulation of small GTPase mediated signal transduction; B cell homeostasis; small GTPase mediated signal transduction; positive regulation of epidermal growth factor receptor signaling pathway; Ras protein signal transduction; regulation of Rho protein signal transduction; insulin receptor signaling pathway; innate immune response; blood coagulation; vascular endothelial growth factor receptor signaling pathway; leukocyte migration; positive regulation of GTPase activity
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.