a guanine nucleotide exchange factor that activates Ras by catalyzing the exchange of bound GDP for GTP. Interacts with GRB2, NCK, and other adapter proteins. Plays an important role in signaling pathways leading from the G-protein- coupled receptors and receptor tyrosine kinases to MAPK/ERK. Note: This description may include information from UniProtKB.
Protein type: Guanine nucleotide exchange factor, Ras; Adaptor/scaffold; Motility/polarity/chemotaxis
Cellular Component: plasma membrane; cytosol
Molecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; DNA binding; protein heterodimerization activity; Rho GTPase activator activity; phospholipid binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: epidermal growth factor receptor signaling pathway; platelet activation; axon guidance; regulation of small GTPase mediated signal transduction; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction; Ras protein signal transduction; insulin receptor signaling pathway; innate immune response; signal transduction; blood coagulation; leukocyte migration; positive regulation of Rho GTPase activity
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.