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Protein Page:
SOS1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SOS1 a guanine nucleotide exchange factor that activates Ras by catalyzing the exchange of bound GDP for GTP. Interacts with GRB2, NCK, and other adapter proteins. Plays an important role in signaling pathways leading from the G-protein- coupled receptors and receptor tyrosine kinases to MAPK/ERK. Note: This description may include information from UniProtKB.
Protein type: GEFs; Adaptor/scaffold; Motility/polarity/chemotaxis; GEFs, Ras
Cellular Component: cell soma; postsynaptic density; plasma membrane; cytosol
Molecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; DNA binding; protein heterodimerization activity; Rho GTPase activator activity; SH3 domain binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: epidermal growth factor receptor signaling pathway; axon guidance; platelet activation; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; signal transduction; positive regulation of small GTPase mediated signal transduction; positive regulation of Ras GTPase activity; regulation of small GTPase mediated signal transduction; positive regulation of epidermal growth factor receptor signaling pathway; small GTPase mediated signal transduction; Ras protein signal transduction; insulin receptor signaling pathway; innate immune response; blood coagulation; leukocyte migration; positive regulation of Rho GTPase activity
Reference #:  Q07889 (UniProtKB)
Alt. Names/Synonyms: GF1; GGF1; GINGF; gingival fibromatosis, hereditary, 1; HGF; NS4; Son of sevenless homolog 1; son of sevenless homolog 1 (Drosophila); SOS-1; SOS1
Gene Symbols: SOS1
Molecular weight: 152,464 Da
Basal Isoelectric point: 6.38  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-├č Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SOS1

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: S1132‑p, S1167‑p, S1178‑p, S1193‑p, S1197‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 Y155-p YVRNIRHyEItKQDI
1 0 T158-p NIRHyEItKQDIKVA
0 1 S238 VSNSKLFSANDVENI
0 1 A239 SNSKLFSANDVENIF
0 1 S401-p SLAKRRLsESACRFY
0 1 K413-m1 RFYSQQMkGkQLAIk
0 1 K413-ub RFYSQQMkGkQLAIk
0 1 K415-ub YSQQMkGkQLAIkkM
0 1 K420-m1 kGkQLAIkkMNEIQK
0 2 K421-ub GkQLAIkkMNEIQKN
0 1 S523 IILKDENSVIFSAKS
0 8 Y618-p ERLTYHMyADPNFVR
0 1 S853-p EERVAVVsRIIEILQ
0 1 S1000-p NLNPMGNsMEKEFtD
0 1 T1006-p NsMEKEFtDYLFNKS
0 1 Y1033-p RFPKKYSyPLKSPGV
0 1 S1043-p KSPGVRPsNPRPGTM
0 1 S1064-p QQEPRKIsySRIPES
0 2 Y1065-p QEPRKIsySRIPESE
0 1 T1076 PESETESTAsAPNsP
0 9 S1078-p SETESTAsAPNsPRT
0 19 S1082-p STAsAPNsPRTPLTP
0 1 T1085 sAPNsPRTPLTPPPA
0 5 T1088 NsPRTPLTPPPASGA
0 1 S1111 VFDSDHSSPFHSSND
0 1 S1115 DHSSPFHSSNDTVFI
1 0 S1132-p TLPHGPRsAsVSsIS
1 16 S1134-p PHGPRsAsVSsISLT
0 9 S1137-p PRsAsVSsISLTKGT
1 17 S1161-p PPRRRPEsAPAEssP
0 2 S1166-p PEsAPAEssPsKIMS
1 2 S1167-p EsAPAEssPsKIMSK
0 1 S1169-p APAEssPsKIMSKHL
1 7 S1178-p IMSKHLDsPPAIPPR
0 1 K1190-ac PPRQPTSkAYsPRys
1 0 S1193-p QPTSkAYsPRysISD
0 1 Y1196-p SkAYsPRysISDRTS
1 0 S1197-p kAYsPRysISDRTSI
0 7 S1210-p SISDPPEsPPLLPPR
0 1 T1222-p PPREPVRtPDVFSSs
0 2 S1229-p tPDVFSSsPLHLQPP
0 1 S1242 PPPLGKKSDHGNAFF
0 3 S1252-p GNAFFPNsPSPFtPP
0 1 S1254 AFFPNsPSPFtPPPP
0 5 T1257-p PNsPSPFtPPPPQtP
0 7 T1263-p FtPPPPQtPsPHGtR
0 2 S1265-p PPPPQtPsPHGtRRH
0 1 T1269-p QtPsPHGtRRHLPsP
0 9 S1275-p GtRRHLPsPPLTQEV
0 1 T1279 HLPsPPLTQEVDLHS
0 2 S1297-p PPVPPRQstsQHIPK
0 2 T1298-p PVPPRQstsQHIPKL
0 2 S1299-p VPPRQstsQHIPKLP
0 2 S1332-p PLLENAHsS______
  mouse

 
Y155 YVRNIRHYEITKQDI
T158 NIRHYEITKQDIKVA
S238-p VSNSKLFssNDVENI
S239-p SNSKLFssNDVENIF
S401-p SLAKRRLsESACRFY
K413 RFYSQQMKGKQLAIK
K413 RFYSQQMKGKQLAIK
K415 YSQQMKGKQLAIKKM
K420 KGKQLAIKKMNEIQK
K421 GKQLAIKKMNEIQKN
S523-p IILKDGNsVIFSAKS
Y618-p ERLTYHMyADPNFVR
S853 EERVAVVSRIIEILQ
S1000 NLNPMGNSMEKEFTD
T1006 NSMEKEFTDYLFNKS
Y1033 RFPKKYSYPLKSPGV
S1043 KSPGVRPSNPRPGTM
S1064 QQEPRKISYSRIPES
Y1065 QEPRKISYSRIPESE
T1076-p PESETEStAsAPNsP
S1078-p SETEStAsAPNsPRt
S1082-p StAsAPNsPRtPLtP
T1085-p sAPNsPRtPLtPPPA
T1088-p NsPRtPLtPPPASGT
S1112-p FDSDHSAsPFHsRSA
S1116-p HSAsPFHsRSAsVSs
S1118 AsPFHsRSAsVSsIS
S1120-p PFHsRSAsVSsISLS
S1123-p sRSAsVSsISLSKGT
S1147 PPRRRPESAPAESSP
S1152 PESAPAESSPSKIMS
S1153 ESAPAESSPSKIMSK
S1155 APAESSPSKIMSKHL
S1164-p IMSKHLDsPPAIPPR
K1176 PPRQPTSKAYSPRYS
S1179 QPTSKAYSPRYSISD
Y1182 SKAYSPRYSISDRTS
S1183 KAYSPRYSISDRTSI
S1196-p SISDPPEsPPLLPPR
T1208 PPREPVRTPDVFSSs
S1215-p TPDVFSSsPLHLQPP
S1228-p PPPLGKKsDHGNAFF
S1238-p GNAFFPNsPsPFtPP
S1240-p AFFPNsPsPFtPPPP
T1243-p PNsPsPFtPPPPQtP
T1249-p FtPPPPQtPsPHGtR
S1251-p PPPPQtPsPHGtRRH
T1255-p QtPsPHGtRRHLPsP
S1261-p GtRRHLPsPPLtQEM
T1265-p HLPsPPLtQEMDLHS
S1283 PPVPPRQSTSQLIPK
T1284 PVPPRQSTSQLIPKL
S1285 VPPRQSTSQLIPKLP
S1318-p PLLENAHsS______
  rat

 
Y155 YVRNIRHYEITKQDI
T158 NIRHYEITKQDIKVA
S238 VSNSKLFSSYDVENI
S239 SNSKLFSSYDVENIF
S401 NLAKRRLSESACRFY
K413 RFYSQQMKGKQLAIK
K413 RFYSQQMKGKQLAIK
K415 YSQQMKGKQLAIKKM
K420 KGKQLAIKKMNEIQK
K421 GKQLAIKKMNEIQKN
S523 IILKDGNSVIFSAKS
Y618 ERLTYHMYADPNFVR
S853 EERVAVVSRIIEILQ
S1000 NLNPMGNSMEKEFTD
T1006 NSMEKEFTDYLFNKS
Y1033 RFPKKYSYPLKSPGV
S1043 KSPGVRPSNPRPGTM
S1064 QQEPRKISYSRIPES
Y1065 QEPRKISYSRIPESE
T1076 PESETESTASAPNsP
S1078 SETESTASAPNsPRT
S1082-p STASAPNsPRTPLTP
T1085 SAPNsPRTPLTPPPA
T1088 NsPRTPLTPPPASSA
S1112 FDSDHSASPFHSRSA
S1116 HSASPFHSRSAsVSS
S1118 ASPFHSRSAsVSSIS
S1120-p PFHSRSAsVSSISLS
S1123 SRSAsVSSISLSKGT
S1147 PPRRRPESAPAESSP
S1152 PESAPAESSPSKIMS
S1153 ESAPAESSPSKIMSK
S1155 APAESSPSKIMSKHL
S1164 IMSKHLDSPPAIPPR
K1176 PPRQPTSKAYSPRYS
S1179 QPTSKAYSPRYSISD
Y1182 SKAYSPRYSISDRTS
S1183 KAYSPRYSISDRTSI
S1196 SISDPPESPPLLPPR
T1208 PPREPVRTPDVFSSS
S1215 TPDVFSSSPLHLQPP
S1228 PPPLGKKSDHGNAFF
S1238 GNAFFPNSPSPFTPP
S1240 AFFPNSPSPFTPPPP
T1243 PNSPSPFTPPPPQTP
T1249 FTPPPPQTPSPHGTR
S1251 PPPPQTPSPHGTRRH
T1255 QTPSPHGTRRHLPSP
S1261 GTRRHLPSPPLTQEV
T1265 HLPSPPLTQEVDLHS
S1283 PPVPPRQSTSQLIPK
T1284 PVPPRQSTSQLIPKL
S1285 VPPRQSTSQLIPKLP
S1318 PLLENAHSS______
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