Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
SOS1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SOS1 a guanine nucleotide exchange factor that activates Ras by catalyzing the exchange of bound GDP for GTP. Interacts with GRB2, NCK, and other adapter proteins. Plays an important role in signaling pathways leading from the G-protein- coupled receptors and receptor tyrosine kinases to MAPK/ERK. Note: This description may include information from UniProtKB.
Protein type: Guanine nucleotide exchange factor, Ras; Motility/polarity/chemotaxis; Adaptor/scaffold
Cellular Component: plasma membrane; cytosol
Molecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; DNA binding; protein heterodimerization activity; Rho GTPase activator activity; phospholipid binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: epidermal growth factor receptor signaling pathway; platelet activation; axon guidance; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; apoptosis; signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; Ras protein signal transduction; insulin receptor signaling pathway; blood coagulation; leukocyte migration; positive regulation of Rho GTPase activity
Reference #:  Q07889 (UniProtKB)
Alt. Names/Synonyms: GF1; GGF1; GINGF; gingival fibromatosis, hereditary, 1; guanine nucleotide exchange factor; HGF; NS4; Son of sevenless homolog 1; son of sevenless homolog 1 (Drosophila); SOS-1; SOS1
Gene Symbols: SOS1
Molecular weight: 152,464 Da
Basal Isoelectric point: 6.38  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCRs Signaling to MAPK/Erk  |  Insulin Receptor Signaling  |  MAPK/Erk in Growth and Differentiation  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SOS1
Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
molecular association, regulation: S1132‑p, S1167‑p, S1178‑p, S1193‑p, S1197‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 3 Y155-p YVRNIRHyEITKQDI
0 1 S238 VSNSKLFSANDVENI
0 1 A239 SNSKLFSANDVENIF
0 1 S401-p SLAKRRLsESACRFY
0 1 K413-m1 RFYSQQMkGkQLAIk
0 1 K413-u RFYSQQMkGkQLAIk
0 1 K415-u YSQQMkGkQLAIkkM
0 1 K420-m1 kGkQLAIkkMNEIQK
0 2 K421-u GkQLAIkkMNEIQKN
0 1 S523 IILKDENSVIFSAKS
0 6 Y618-p ERLTYHMyADPNFVR
0 1 Y1033-p RFPKKYSyPLKSPGV
0 1 S1043-p KSPGVRPsNPRPGTM
0 2 Y1065-p QEPRKISySRIPESE
0 1 T1076 PESETESTAsAPNsP
0 5 S1078-p SETESTAsAPNsPRt
0 12 S1082-p STAsAPNsPRtPLtP
0 1 T1085-p sAPNsPRtPLtPPPA
0 4 T1088-p NsPRtPLtPPPASGA
0 1 S1111-p VFDSDHSsPFHSSND
0 1 S1115 DHSsPFHSSNDTVFI
1 0 S1132-p TLPHGPRsAsVSsIS
1 11 S1134-p PHGPRsAsVSsISLT
0 6 S1137-p PRsAsVSsISLTKGT
1 7 S1161-p PPRRRPEsAPAEssP
0 2 S1166-p PEsAPAEssPsKIMS
1 1 S1167-p EsAPAEssPsKIMSK
0 1 S1169-p APAEssPsKIMSKHL
1 3 S1178-p IMSKHLDsPPAIPPR
0 1 K1190-a PPRQPTSkAYsPRYs
1 0 S1193-p QPTSkAYsPRYsISD
1 0 S1197-p kAYsPRYsISDRTSI
0 4 S1210-p SISDPPEsPPLLPPR
0 1 S1242 PPPLGKKSDHGNAFF
0 2 S1252-p GNAFFPNsPSPFtPP
0 1 S1254 AFFPNsPSPFtPPPP
0 5 T1257-p PNsPSPFtPPPPQtP
0 7 T1263-p FtPPPPQtPsPHGtR
0 2 S1265-p PPPPQtPsPHGtRRH
0 1 T1269-p QtPsPHGtRRHLPsP
0 4 S1275-p GtRRHLPsPPLTQEV
0 1 T1279 HLPsPPLTQEVDLHS
0 1 S1297-p PPVPPRQstsQHIPK
0 1 T1298-p PVPPRQstsQHIPKL
0 1 S1299-p VPPRQstsQHIPKLP
0 1 S1332 PLLENAHSS______
  mouse

 
Y155 YVRNIRHYEITKQDI
S238-p VSNSKLFssNDVENI
S239-p SNSKLFssNDVENIF
S401-p SLAKRRLsESACRFY
K413 RFYSQQMKGKQLAIK
K413 RFYSQQMKGKQLAIK
K415 YSQQMKGKQLAIKKM
K420 KGKQLAIKKMNEIQK
K421 GKQLAIKKMNEIQKN
S523-p IILKDGNsVIFSAKS
Y618-p ERLTYHMyADPNFVR
Y1033 RFPKKYSYPLKSPGV
S1043 KSPGVRPSNPRPGTM
Y1065 QEPRKISYSRIPESE
T1076-p PESETEStAsAPNsP
S1078-p SETEStAsAPNsPRt
S1082-p StAsAPNsPRtPLtP
T1085-p sAPNsPRtPLtPPPA
T1088-p NsPRtPLtPPPASGT
S1112-p FDSDHSAsPFHsRSA
S1116-p HSAsPFHsRSAsVSs
S1118 AsPFHsRSAsVSsIS
S1120-p PFHsRSAsVSsISLS
S1123-p sRSAsVSsISLSKGT
S1147 PPRRRPESAPAESSP
S1152 PESAPAESSPSKIMS
S1153 ESAPAESSPSKIMSK
S1155 APAESSPSKIMSKHL
S1164-p IMSKHLDsPPAIPPR
K1176 PPRQPTSKAYSPRYS
S1179 QPTSKAYSPRYSISD
S1183 KAYSPRYSISDRTSI
S1196-p SISDPPEsPPLLPPR
S1228-p PPPLGKKsDHGNAFF
S1238-p GNAFFPNsPsPFtPP
S1240-p AFFPNsPsPFtPPPP
T1243-p PNsPsPFtPPPPQtP
T1249-p FtPPPPQtPsPHGtR
S1251-p PPPPQtPsPHGtRRH
T1255-p QtPsPHGtRRHLPsP
S1261-p GtRRHLPsPPLtQEM
T1265-p HLPsPPLtQEMDLHS
S1283 PPVPPRQSTSQLIPK
T1284 PVPPRQSTSQLIPKL
S1285 VPPRQSTSQLIPKLP
S1318-p PLLENAHsS______
  rat

 
Y155 YVRNIRHYEITKQDI
S238 VSNSKLFSSYDVENI
S239 SNSKLFSSYDVENIF
S401 NLAKRRLSESACRFY
K413 RFYSQQMKGKQLAIK
K413 RFYSQQMKGKQLAIK
K415 YSQQMKGKQLAIKKM
K420 KGKQLAIKKMNEIQK
K421 GKQLAIKKMNEIQKN
S523 IILKDGNSVIFSAKS
Y618 ERLTYHMYADPNFVR
Y1033 RFPKKYSYPLKSPGV
S1043 KSPGVRPSNPRPGTM
Y1065 QEPRKISYSRIPESE
T1076 PESETESTASAPNsP
S1078 SETESTASAPNsPRT
S1082-p STASAPNsPRTPLTP
T1085 SAPNsPRTPLTPPPA
T1088 NsPRTPLTPPPASSA
S1112 FDSDHSASPFHSRSA
S1116 HSASPFHSRSASVSS
S1118 ASPFHSRSASVSSIS
S1120 PFHSRSASVSSISLS
S1123 SRSASVSSISLSKGT
S1147 PPRRRPESAPAESSP
S1152 PESAPAESSPSKIMS
S1153 ESAPAESSPSKIMSK
S1155 APAESSPSKIMSKHL
S1164 IMSKHLDSPPAIPPR
K1176 PPRQPTSKAYSPRYS
S1179 QPTSKAYSPRYSISD
S1183 KAYSPRYSISDRTSI
S1196 SISDPPESPPLLPPR
S1228 PPPLGKKSDHGNAFF
S1238 GNAFFPNSPSPFTPP
S1240 AFFPNSPSPFTPPPP
T1243 PNSPSPFTPPPPQTP
T1249 FTPPPPQTPSPHGTR
S1251 PPPPQTPSPHGTRRH
T1255 QTPSPHGTRRHLPSP
S1261 GTRRHLPSPPLTQEV
T1265 HLPSPPLTQEVDLHS
S1283 PPVPPRQSTSQLIPK
T1284 PVPPRQSTSQLIPKL
S1285 VPPRQSTSQLIPKLP
S1318 PLLENAHSS______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.