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Protein Page:
PTP-PEST (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
PTP-PEST Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2. Interacts with TGFB1I1. Interacts with PSTPIP1. Interacts with PTK2B/PYK2. Interacts with LPXN. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
Cellular Component: cell projection; cytoplasm; plasma membrane; podosome; cytosol; cell junction
Molecular Function: protein binding; non-membrane spanning protein tyrosine phosphatase activity; SH3 domain binding
Biological Process: protein amino acid dephosphorylation
Reference #:  Q05209 (UniProtKB)
Alt. Names/Synonyms: protein tyrosine phosphatase, non-receptor type 12; Protein-tyrosine phosphatase G1; PTN12; PTPG1; PTPN12; Tyrosine-protein phosphatase non-receptor type 12
Gene Symbols: PTPN12
Molecular weight: 88,106 Da
Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PTP-PEST

Protein Structure Not Found.


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Sites Implicated In
activity, inhibited: S39‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 6 S19-p QRVQAMKsPDHNGED
3 15 S39-p FMRLRRLstKYRTEK
0 3 T40-p MRLRRLstKYRTEKI
0 7 Y64-p ENVKKNRyKDILPFD
0 4 Y88-p TPSQDSDyINANFIK
0 1 S186 LLEFQNESRRLYQFH
0 1 K296 AIAQLFEKQLQLyEI
0 1 Y301-p FEKQLQLyEIHGAQK
0 1 T318-p DGVNEINtENMVssI
0 1 N320 VNEINtENMVssIEP
0 3 S323-p INtENMVssIEPEKQ
0 2 S324-p NtENMVssIEPEKQD
0 3 P327 NMVssIEPEKQDsPP
0 16 S332-p IEPEKQDsPPPKPPR
0 2 S369-p VPPILTPsPPSAFPT
0 3 S397 KPVLHMVSSEQHSAD
0 1 N408 HSADLNRNYSKSTEL
2 66 S435-p KKLERNLsFEIKKVP
0 13 S449-p PLQEGPKsFDGNTLL
0 1 S466-p GHAIKIKsAsPCIAD
0 2 S468-p AIKIKsAsPCIADKI
0 1 T490-p SDLNVGDtsQNsCVD
0 1 S491-p DLNVGDtsQNsCVDC
0 1 S494-p VGDtsQNsCVDCSVT
0 1 S507-p VTQSNKVsVtPPEEs
0 14 T509-p QSNKVsVtPPEEsQN
0 8 S514-p sVtPPEEsQNsDtPP
0 8 S517-p PPEEsQNsDtPPRPD
0 13 T519-p EEsQNsDtPPRPDRL
0 11 L550 NAIPIPDLSEGNSSD
0 3 S555 PDLSEGNSSDINYQT
0 1 Y560 GNSSDINYQTRKTVs
0 1 S567-p YQTRKTVsLtPsPtT
0 5 T569-p TRKTVsLtPsPtTQV
1 7 S571-p KTVsLtPsPtTQVEt
0 1 T573-p VsLtPsPtTQVEtPD
0 1 T578-p sPtTQVEtPDLVDHD
0 4 S588-p LVDHDNTsPLFRtPL
0 1 T593-p NTsPLFRtPLsFTNP
0 2 S596-p PLFRtPLsFTNPLHs
0 2 T598 FRtPLsFTNPLHsDD
0 18 S603-p sFTNPLHsDDsDsDE
0 19 S606-p NPLHsDDsDsDERNs
0 9 S608-p LHsDDsDsDERNsDG
0 1 N612 DsDsDERNsDGAVTQ
0 2 S613-p sDsDERNsDGAVTQN
0 1 T622-p GAVTQNKtNISTASA
0 1 S625 TQNKtNISTASATVS
0 1 T626 QNKtNISTASATVSA
0 1 T630 NISTASATVSAATST
0 1 S632 STASATVSAATSTES
0 1 T642 TSTESISTRKVLPMs
0 1 S649-p TRKVLPMsIARHNIA
0 1 S661-p NIAGTTHsGAEKDVD
0 5 S670-p AEKDVDVsEDsPPPL
0 26 S673-p DVDVsEDsPPPLPER
0 1 T681-p PPPLPERtPESFVLA
0 4 S689-p PESFVLAsEHNtPVR
0 5 T693-p VLAsEHNtPVRSEWS
0 1 C736 GGIHYEMCIECPPTF
0 2 C739 HYEMCIECPPTFSDK
0 1 S751 SDKREQISENPTEAT
0 10 N753 KREQISENPTEATDI
0 1 T758 SENPTEATDIGFGNR
0 1 T780-p RDPPSEWt_______
  mouse

 
S19-p QRVQAMKsPDHNGED
S39-p FMRLRRLsTKYRTEK
T40 MRLRRLsTKYRTEKI
Y64-p ENVKKNRyKDILPFD
Y88 TPSQDSDYINANFIK
S186-p LLEFQNEsRRLYQFH
K296-ub AIAQLFEkQLQLYEI
Y301 FEkQLQLYEIHGAQK
T317 ADGNEITTGtMVssI
T319-p GNEITTGtMVssIDs
S322-p ITTGtMVssIDsEKQ
S323-p TTGtMVssIDsEKQD
S326-p tMVssIDsEKQDsPP
S331-p IDsEKQDsPPPKPPR
S368-p VPPILTPsPPSAFPT
S396-p KPVLHMAsPEQHPAD
S407-p HPADLNRsYDKSADP
S434-p KKLERNLsFEIKKVP
S448-p PLQEGPKsFDGNTLL
S465 GHAIKIKSASSSVVD
S467 AIKIKSASSSVVDRT
V490 GALKVDDVSQNSCAD
S491 ALKVDDVSQNSCADC
S494 VDDVSQNSCADCSAA
- gap
S509 HSHRAAESSEESQSN
Q514 AESSEESQSNSHtPP
S517 SEESQSNSHtPPRPD
T519-p ESQSNSHtPPRPDCL
S550-p NATPVPDsPDGKsPD
S555-p PDsPDGKsPDNHsQT
S560-p GKsPDNHsQTLKTVS
S567 sQTLKTVSSTPNSTA
T569 TLKTVSSTPNSTAEE
S572 TVSSTPNSTAEEEAH
T573 VSSTPNSTAEEEAHD
- gap
S588 LTEHHNSSPLLKAPL
A593 NSSPLLKAPLsFtNP
S596-p PLLKAPLsFtNPLHs
T598-p LKAPLsFtNPLHsDD
S603-p sFtNPLHsDDsDsDG
S606-p NPLHsDDsDsDGGss
S608-p LHsDDsDsDGGssDG
S612-p DsDsDGGssDGAVTR
S613-p sDsDGGssDGAVTRN
T622 GAVTRNKTSIstASA
S625-p TRNKTSIstASAtVs
T626-p RNKTSIstASAtVsP
T630-p SIstASAtVsPASSA
S632-p stASAtVsPASSAES
T642-p SSAESACtRRVLPMS
S649 tRRVLPMSIARQEVA
S661 EVAGTPHSGAEKDAD
S670 AEKDADVSEEsPPPL
S673-p DADVSEEsPPPLPER
T681 PPPLPERTPESFVLA
- gap
M690 ESFVLADMPVRPEWH
S731-p GGIHTEAsADsPPAF
S734-p HTEAsADsPPAFSDK
T746-p SDKKDQItKsPAEVt
S748-p KKDQItKsPAEVtDI
T753-p tKsPAEVtDIGFGNR
T775 REPPSEWT_______
  rat

 
S19 QRVQAMKSPDHNGED
S39 FMRLRRLSTKYRTEK
T40 MRLRRLSTKYRTEKI
Y64 ENVKKNRYKDILPFD
Y88 TPSQDSDYINANFIK
S186 LLEFQNESRRLYQFH
K296 AIAQLFEKQLQLYEI
Y301 FEKQLQLYEIHGAQK
T317 TDGNEISTGNMVSSI
N319 GNEISTGNMVSSIDS
S322 ISTGNMVSSIDSEKQ
S323 STGNMVSSIDSEKQD
S326 NMVSSIDSEKQDsPP
S331-p IDSEKQDsPPPKPPR
S368 VPPILTPSPPSAFPT
S396 KPVLHMASPEQPPTD
N407 PPTDLNRNYDKSADL
S434 KKLEQNLSFEIKKVP
S448 PLQEGPKSFDGNTLL
S465 GHAIKIKSASSSVVD
S467 AIKIKSASSSVVDKS
V490 GDLKVHDVSQNSCAD
S491 DLKVHDVSQNSCADC
S494 VHDVSQNSCADCSAS
- gap
S509 HLDNAPESSEESQNS
S513 APESSEESQNSHTPP
S516 SSEESQNSHTPPRPD
T518 EESQNSHTPPRPDCL
S549 NATPVSDSPDNHSQT
- gap
S554 SDSPDNHSQTLKTVS
S561 SQTLKTVSSTPNSTA
T563 TLKTVSSTPNSTAEE
S566 TVSSTPNSTAEEESH
T567 VSSTPNSTAEEESHD
S572 NSTAEEESHDLTEHH
S582 LTEHHNSSPLPRAPL
A587 NSSPLPRAPLSFTNP
S590 PLPRAPLSFTNPLHs
T592 PRAPLSFTNPLHsDD
S597-p SFTNPLHsDDsDsDE
S600-p NPLHsDDsDsDEGNS
S602-p LHsDDsDsDEGNSDG
N606 DsDsDEGNSDGAVTK
S607 sDsDEGNSDGAVTKN
T616 GAVTKNKTSISTASA
S619 TKNKTSISTASATVS
T620 KNKTSISTASATVSP
T624 SISTASATVSPASST
S626 STASATVSPASSTES
T636 SSTESACTRRVLPMS
S643 TRRVLPMSIARQEMA
S655-p EMAGRRHsGAEKDAD
S664 AEKDADVSEEsPPPL
S667-p DADVSEEsPPPLPER
T675 PPPLPERTPESFVLA
- gap
M684 ESFVLADMPIRSDWH
C725 GVSHTAACSPTFSDK
- gap
T737 SDKKEEITESLTEVT
S739 KKEEITESLTEVTDI
T744 TESLTEVTDIGFGNR
T766 RDPPSEWT_______
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