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PTP-PEST (human)

Overview PTP-PEST Dephosphorylates cellular tyrosine kinases, including PTK2B/PYK2, and thereby regulates signaling via PTK2B/PYK2. Interacts with TGFB1I1. Interacts with PSTPIP1. Interacts with PTK2B/PYK2. Interacts with LPXN. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48 Cellular Component: cell projection; cytoplasm; plasma membrane; podosome; cytosol; cell junction Molecular Function: protein binding; non-membrane spanning protein tyrosine phosphatase activity; SH3 domain binding Biological Process: protein amino acid dephosphorylation Reference #:  Q05209 (UniProtKB) Alt. Names/Synonyms: protein tyrosine phosphatase, non-receptor type 12; Protein-tyrosine phosphatase G1; PTN12; PTPG1; PTPN12; Tyrosine-protein phosphatase non-receptor type 12 Gene Symbols: PTPN12 Molecular weight: 88,106 Da Basal Isoelectric point: 5.4  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below PTP-PEST

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	Sites Implicated In
inhibition: S39‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		S19-p	QRVQAMKsPDHNGED
2	15		S39-p	FMRLRRLstKYRTEK
0	3		T40-p	MRLRRLstKYRTEKI
0	4		Y64-p	ENVKKNRyKDILPFD
0	4		Y88-p	TPSQDSDyINANFIK
0	1		S186	LLEFQNESRRLYQFH
0	1		K296	AIAQLFEKQLQLyEI
0	1		Y301-p	FEKQLQLyEIHGAQK
0	1		T318-p	DGVNEINtENMVssI
0	3		S323-p	INtENMVssIEPEKQ
0	2		S324-p	NtENMVssIEPEKQD
0	2		P327	NMVssIEPEKQDsPP
0	10		S332-p	IEPEKQDsPPPKPPR
0	1		S369	VPPILTPSPPSAFPT
0	3		S397	KPVLHMVSSEQHSAD
0	1		N408	HSADLNRNYSKSTEL
1	56		S435-p	KKLERNLsFEIKKVP
0	10		S449-p	PLQEGPKsFDGNTLL
0	1		S468-p	AIKIKSAsPCIADKI
0	1		S507-p	VTQSNKVsVtPPEEs
0	12		T509-p	QSNKVsVtPPEEsQN
0	7		S514-p	sVtPPEEsQNsDtPP
0	7		S517-p	PPEEsQNsDtPPRPD
0	11		T519-p	EEsQNsDtPPRPDRL
0	10		L550	NAIPIPDLSEGNSSD
0	3		S555	PDLSEGNSSDINYQT
0	1		Y560	GNSSDINYQTRKTVs
0	1		S567-p	YQTRKTVsLtPsPtT
0	4		T569-p	TRKTVsLtPsPtTQV
1	5		S571-p	KTVsLtPsPtTQVET
0	1		T573-p	VsLtPsPtTQVETPD
0	3		S588-p	LVDHDNTsPLFRTPL
0	2		S596-p	PLFRTPLsFTNPLHs
0	2		T598	FRTPLsFTNPLHsDD
0	13		S603-p	sFTNPLHsDDsDsDE
0	14		S606-p	NPLHsDDsDsDERNs
0	8		S608-p	LHsDDsDsDERNsDG
0	1		N612	DsDsDERNsDGAVTQ
0	2		S613-p	sDsDERNsDGAVTQN
0	1		S625	TQNKTNISTASATVS
0	1		T626	QNKTNISTASATVSA
0	1		T630	NISTASATVSAATST
0	1		S632	STASATVSAATSTES
0	1		T642	TSTESISTRKVLPMs
0	1		S649-p	TRKVLPMsIARHNIA
0	4		S670-p	AEKDVDVsEDsPPPL
0	19		S673-p	DVDVsEDsPPPLPER
0	3		S689-p	PESFVLAsEHNtPVR
0	4		T693-p	VLAsEHNtPVRSEWS
0	1		C736	GGIHYEMCIECPPTF
0	2		C739	HYEMCIECPPTFSDK
0	9		N753	KREQISENPTEATDI

	mouse
S19-p	QRVQAMKsPDHNGED
S39-p	FMRLRRLsTKYRTEK
T40	MRLRRLsTKYRTEKI
Y64-p	ENVKKNRyKDILPFD
Y88	TPSQDSDYINANFIK
S186-p	LLEFQNEsRRLYQFH
K296-u	AIAQLFEkQLQLYEI
Y301	FEkQLQLYEIHGAQK
T317	ADGNEITTGTMVssI
S322-p	ITTGTMVssIDsEKQ
S323-p	TTGTMVssIDsEKQD
S326-p	TMVssIDsEKQDsPP
S331-p	IDsEKQDsPPPKPPR
S368-p	VPPILTPsPPSAFPT
S396-p	KPVLHMAsPEQHPAD
S407-p	HPADLNRsYDKSADP
S434-p	KKLERNLsFEIKKVP
S448-p	PLQEGPKsFDGNTLL
S467	AIKIKSASSSVVDRT
-	gap
S509	HSHRAAESSEESQSN
Q514	AESSEESQSNSHtPP
S517	SEESQSNSHtPPRPD
T519-p	ESQSNSHtPPRPDCL
S550-p	NATPVPDsPDGKsPD
S555-p	PDsPDGKsPDNHsQT
S560-p	GKsPDNHsQTLKTVS
S567	sQTLKTVSSTPNSTA
T569	TLKTVSSTPNSTAEE
S572	TVSSTPNSTAEEEAH
T573	VSSTPNSTAEEEAHD
S588	LTEHHNSSPLLKAPL
S596-p	PLLKAPLsFtNPLHs
T598-p	LKAPLsFtNPLHsDD
S603-p	sFtNPLHsDDsDsDG
S606-p	NPLHsDDsDsDGGss
S608-p	LHsDDsDsDGGssDG
S612-p	DsDsDGGssDGAVTR
S613-p	sDsDGGssDGAVTRN
S625-p	TRNKTSIstASAtVs
T626-p	RNKTSIstASAtVsP
T630-p	SIstASAtVsPASSA
S632-p	stASAtVsPASSAES
T642-p	SSAESACtRRVLPMS
S649	tRRVLPMSIARQEVA
S670	AEKDADVSEEsPPPL
S673-p	DADVSEEsPPPLPER
-	gap
M690	ESFVLADMPVRPEWH
S731-p	GGIHTEAsADsPPAF
S734-p	HTEAsADsPPAFSDK
S748-p	KKDQITKsPAEVTDI

	rat
S19	QRVQAMKSPDHNGED
S39	FMRLRRLSTKYRTEK
T40	MRLRRLSTKYRTEKI
Y64	ENVKKNRYKDILPFD
Y88	TPSQDSDYINANFIK
S186	LLEFQNESRRLYQFH
K296	AIAQLFEKQLQLYEI
Y301	FEKQLQLYEIHGAQK
T317	TDGNEISTGNMVSSI
S322	ISTGNMVSSIDSEKQ
S323	STGNMVSSIDSEKQD
S326	NMVSSIDSEKQDSPP
S331	IDSEKQDSPPPKPPR
S368	VPPILTPSPPSAFPT
S396	KPVLHMASPEQPPTD
N407	PPTDLNRNYDKSADL
S434	KKLEQNLSFEIKKVP
S448	PLQEGPKSFDGNTLL
S467	AIKIKSASSSVVDKS
-	gap
S509	HLDNAPESSEESQNS
S513	APESSEESQNSHTPP
S516	SSEESQNSHTPPRPD
T518	EESQNSHTPPRPDCL
S549	NATPVSDSPDNHSQT
-	gap
S554	SDSPDNHSQTLKTVS
S561	SQTLKTVSSTPNSTA
T563	TLKTVSSTPNSTAEE
S566	TVSSTPNSTAEEESH
T567	VSSTPNSTAEEESHD
S582	LTEHHNSSPLPRAPL
S590	PLPRAPLSFTNPLHs
T592	PRAPLSFTNPLHsDD
S597-p	SFTNPLHsDDsDsDE
S600-p	NPLHsDDsDsDEGNS
S602-p	LHsDDsDsDEGNSDG
N606	DsDsDEGNSDGAVTK
S607	sDsDEGNSDGAVTKN
S619	TKNKTSISTASATVS
T620	KNKTSISTASATVSP
T624	SISTASATVSPASST
S626	STASATVSPASSTES
T636	SSTESACTRRVLPMS
S643	TRRVLPMSIARQEMA
S664	AEKDADVSEEsPPPL
S667-p	DADVSEEsPPPLPER
-	gap
M684	ESFVLADMPIRSDWH
C725	GVSHTAACSPTFSDK
-	gap
S739	KKEEITESLTEVTDI

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