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Protein Page:
HIF2A (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HIF2A Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation seems to require recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerizes with ARNT. Interacts with CREBBP. Interacts with EGLN1. Interacts with VHL. Expressed in most tissues, with highest levels in placenta, lung and heart. Selectively expressed in endothelial cells. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: nucleoplasm; transcription factor complex; cytosol
Molecular Function: histone acetyltransferase binding; protein binding; signal transducer activity; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; transcription factor binding
Biological Process: transcription from RNA polymerase II promoter; mitochondrion organization and biogenesis; myoblast cell fate commitment; embryonic placenta development; regulation of heart rate; cell maturation; norepinephrine metabolic process; signal transduction; visual perception; response to hypoxia; erythrocyte differentiation; blood vessel remodeling; positive regulation of transcription from RNA polymerase II promoter; angiogenesis; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; surfactant homeostasis; lung development
Reference #:  Q99814 (UniProtKB)
Alt. Names/Synonyms: Basic-helix-loop-helix-PAS protein MOP2; BHLHE73; Class E basic helix-loop-helix protein 73; ECYT4; endothelial PAS domain protein 1; Endothelial PAS domain-containing protein 1; EPAS-1; EPAS1; HIF-1-alpha-like factor; HIF-1alpha-like factor; HIF-2-alpha; HIF2-alpha; HIF2A; HLF; hypoxia-inducible factor 2 alpha; Hypoxia-inducible factor 2-alpha; Member of PAS protein 2; MOP2; PAS domain-containing protein 2; PASD2
Gene Symbols: EPAS1
Molecular weight: 96,459 Da
Basal Isoelectric point: 5.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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HIF2A

Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: T324‑p
transcription, altered: T324‑p
molecular association, regulation: T324‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 S10-p ADKEKKRsSsERRKE
0 2 S12-p KEKKRsSsERRKEKS
0 1 S28 DAARCRRSKETEVFY
0 1 T31 RCRRSKETEVFYELA
0 1 S79 SVCSENESEAEADQQ
0 1 Y91 DQQMDNLYLKALEGF
0 1 T103 EGFIAVVTQDGDMIF
0 1 S112 DGDMIFLSENISKFM
0 1 T182-p TVTNRGRtVNLkSAT
0 1 K186-ac RGRtVNLkSATWkVL
0 1 K191-ac NLkSATWkVLHCTGQ
0 1 R247 DSKTFLSRHSMDMKF
0 1 Y307-p GQVVSGQyRMLAKHG
1 0 T324-p VWLETQGtVIYNPRN
1 0 K385-ac GKGAVSEkSNFLFTk
0 1 K385-ub GKGAVSEkSNFLFTk
0 1 K392-ub kSNFLFTkLkEEPEE
1 0 K394-sm NFLFTkLkEEPEELA
1 0 K497-ub TSLDNDLkIEVIEkL
1 1 K503-ub LkIEVIEkLFAMDTE
1 0 K512-ub FAMDTEAkDQCSTQT
1 0 K685-ac TFKTRSAkGFGARGP
1 0 K741-ac HLMWKRMkNLRGGSC
0 1 S795-p AISPGENsKSRFPPQ
1 0 S830 ASRLLGPSFESYLLP
1 0 T840 SYLLPELTRYDCEVN
1 0 Y842 LLPELTRYDCEVNVP
1 0 S853 VNVPVLGSSTLLQGG
  mouse

 
S10-p ADKEKKRsSsELRKE
S12-p KEKKRsSsELRKEKS
S28-p DAARCRRsKEtEVFY
T31-p RCRRsKEtEVFYELA
S79-p SVCSENEsEAEADQQ
Y91-p DQQMDNLyLKALEGF
T103-p EGFIAVVtQDGDMIF
S112-p DGDMIFLsENISKFM
T182 TVTNRGRTVNLKSAT
K186 RGRTVNLKSATWKVL
K191 NLKSATWKVLHCTGQ
R247-m1 DSKTFLSrHSMDMKF
Y307 GQVVSGQYRMLAKHG
T324 VWLETQGTVIYNPRN
K385 DDVAVTEKSNYLFTK
K385 DDVAVTEKSNYLFTK
K392 KSNYLFTKLKEEPEE
K394 NYLFTKLKEEPEELA
K496 SSLENPLKIEVIEKL
K502 LKIEVIEKLFAMDTE
R511 FAMDTEPRDPGSTQT
K689 MFKMRSAKDFGARGP
K745 HLMWKRMKSLMGGTC
A799 TRSSGENAKTGFPPQ
S834-p ASRLLGPsFEPYLLP
T844-p PYLLPELtRyDCEVN
Y846-p LLPELtRyDCEVNVP
S857-p VNVPVPGsSTLLQGR
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