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Rab4 (human)

Overview Rab4 a member of the RAB family of RAS-related GTP-binding proteins, important regulators of vesicular transport and are located in specific intracellular compartments. RAB7 has been localized to late endosomes and shown to be important in the late endocytic pathway. In addition, it has been shown to have a fundamental role in the cellular vacuolation induced by the cytotoxin VacA of Helicobacter pylori. Mutations in this protein cause Charcot-Marie-Tooth type 2B neuropathy. Note: This description may include information from UniProtKB. Protein type: G protein; G protein, monomeric (Rab) Cellular Component: recycling endosome; plasma membrane; cytosol Molecular Function: GTPase activity; ionotropic glutamate receptor binding; protein binding; ATPase activator activity; GDP binding; GTP binding; syntaxin binding; ATPase binding; protein transporter activity Biological Process: small GTPase mediated signal transduction; regulation of endocytosis Reference #:  P20338 (UniProtKB) Alt. Names/Synonyms: HRES-1/RAB4; Oncogene RAB4; RAB4; RAB4, member RAS oncogene family; RAB4A; RAB4A, member RAS oncogene family; Ras-related protein Rab-4A Gene Symbols: RAB4A Molecular weight: 23,871 Da Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Rab4 1YU9 - A=2-172 (human) 1Z0K - A/C=2-172 (human) 2BMD - A=1-184 (human) 2BME - A/B/C/D=1-184 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1YU9 1Z0K 2BMD 2BME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
intracellular localization: S199‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		T19-p	LVIGNAGtGKSCLLH
0	1		T132-p	LDADREVtFLEAsRF
0	1		S137-p	EVtFLEAsRFAQENE
0	2		S185-p	LDPERMGsGIQyGDA
0	1		Y189-p	RMGsGIQyGDAALRQ
1	0		S199-p	AALRQLRsPRRAQAP

	mouse
T19	LVIGNAGTGKSCLLH
T132	LDADREVTFLEASRF
S137	EVTFLEASRFAQENE
S185	LDPERMGSGIQYGDA
Y189	RMGSGIQYGDAALRQ
S199	AALRQLRSPRRTQAP

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