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GATA1
Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells. May form homodimers or heterodimers with other isoforms. Interacts (via the N-terminal zinc finger) with ZFPM1. Interacts with GFI1B. Interacts with PIAS4; the interaction enhances sumoylation and represses the transactivational activity in a sumoylation-independent manner. Interacts with LMCD1. Interacts with CREBBP; the interaction stimulates acetylation and transcriptional activity in vivo. Interacts with EP300. Erythrocytes. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor; DNA binding protein |
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Cellular Component: nucleoplasm; transcription factor complex; nuclear membrane; transcriptional repressor complex; nucleolus; nucleus
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Molecular Function: protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; p53 binding; chromatin binding; transcription factor activity; DNA bending activity
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Biological Process: transcription from RNA polymerase II promoter; erythrocyte development; embryonic hemopoiesis; megakaryocyte differentiation; in utero embryonic development; positive regulation of erythrocyte differentiation; male gonad development; eosinophil differentiation; Sertoli cell development; negative regulation of bone mineralization; negative regulation of cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; cell-cell signaling; positive regulation of osteoblast proliferation; erythrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; platelet formation; blood coagulation; basophil differentiation; negative regulation of apoptosis
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Reference #:
P15976 (UniProtKB)
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| Alt. Names/Synonyms: ERYF1; Erythroid transcription factor; erythroid transcription factor 1; GATA binding protein 1 (globin transcription factor 1); GATA-1; GATA-binding factor 1; GATA1; GF-1; GF1; globin transcription factor 1; NF-E1 DNA-binding protein; NFE1; transcription factor GATA1; XLTT |
| Gene Symbols: GATA1 |
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Molecular weight: 42,751 Da
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Basal Isoelectric point: 9.03
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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