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Protein Page:
GATA1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
GATA1 Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells. May form homodimers or heterodimers with other isoforms. Interacts (via the N-terminal zinc finger) with ZFPM1. Interacts with GFI1B. Interacts with PIAS4; the interaction enhances sumoylation and represses the transactivational activity in a sumoylation-independent manner. Interacts with LMCD1. Interacts with CREBBP; the interaction stimulates acetylation and transcriptional activity in vivo. Interacts with EP300. Erythrocytes. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: nucleoplasm; transcription factor complex; transcriptional repressor complex; nucleus
Molecular Function: protein binding; DNA binding; zinc ion binding; chromatin DNA binding; p53 binding; sequence-specific DNA binding; transcription factor activity; DNA bending activity
Biological Process: transcription from RNA polymerase II promoter; erythrocyte development; in utero embryonic development; megakaryocyte differentiation; embryonic hemopoiesis; positive regulation of erythrocyte differentiation; eosinophil differentiation; male gonad development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; negative regulation of bone mineralization; positive regulation of peptidyl-tyrosine phosphorylation; cell-cell signaling; positive regulation of osteoblast proliferation; erythrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; platelet formation; blood coagulation; basophil differentiation; negative regulation of apoptosis
Reference #:  P15976 (UniProtKB)
Alt. Names/Synonyms: ERYF1; Erythroid transcription factor; erythroid transcription factor 1; GATA binding protein 1 (globin transcription factor 1); GATA-1; GATA-binding factor 1; GATA1; GF-1; GF1; globin transcription factor 1; NF-E1 DNA-binding protein; NFE1; transcription factor GATA1; XLTT
Gene Symbols: GATA1
Molecular weight: 42,751 Da
Basal Isoelectric point: 9.03  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GATA1

Protein Structure Not Found.


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Sites Implicated In
transcription, induced: S26‑p, S310‑p
activity, induced: S26‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
5 0 S26-p VDPALVSsTPESGVF
1 0 A49 DAAASSTAPSTATAA
2 2 S72-p DAEAYRHsPVFQVyP
0 2 Y78-p HsPVFQVyPLLNCME
0 1 S91-p MEGIPGGsPYAGWAY
0 4 S116-p VCPTREDsPPQAVED
0 2 S131-p LDGKGSTsFLETLkT
2 0 K137-sm TsFLETLkTERLSPD
0 1 T138 sFLETLkTERLSPDL
2 0 S142 TLkTERLSPDLLTLG
0 1 Y163 LPVPNSAYGGPDFSS
3 0 S178-p TFFSPTGsPLNSAAY
1 0 S187 LNSAAYSSPKLRGTL
0 2 Y223-p RRDRTGHyLCNACGL
0 2 Y231-p LCNACGLyHKMNGQN
2 1 K245-ac NRPLIRPkkRLIVSK
3 0 K246-ac RPLIRPkkRLIVSKR
1 0 K252 kkRLIVSKRAGTQCT
0 3 Y285-p VCNACGLyyKLHQVN
0 1 Y286-p CNACGLyyKLHQVNR
0 1 T304-p MRKDGIQtRNRKAsG
1 0 K308 GIQtRNRKAsGkGkk
7 0 S310-p QtRNRKAsGkGkkkR
4 0 K312-ac RNRKAsGkGkkkRGs
2 0 K314-ac RKAsGkGkkkRGssL
1 0 K315-ac KAsGkGkkkRGssLG
1 0 K316-ac AsGkGkkkRGssLGG
0 1 S319-p kGkkkRGssLGGtGA
0 1 S320-p GkkkRGssLGGtGAA
0 1 T324-p RGssLGGtGAAEGPA
  mouse

 
S26-p VDSALVSsPSDSTGF
S49-p DAASSSTsPNAATAA
S72-p EAEAYRHsPVFQVYP
Y78 HsPVFQVYPLLNSME
S91 MEGIPGGSPYASWAY
A116 VCPSHEDAPSQALED
T131-p QEGKSNNtFLDTLkt
K137-sm NtFLDTLktERLsPD
T138-p tFLDTLktERLsPDL
S142-p TLktERLsPDLLTLG
Y163-p LPVTGSAyGGADFPS
S178-p PFFSPTGsPLSSAAY
S187-p LSSAAYSsPKFHGSL
Y223 RRDRTGHYLCNACGL
Y231 LCNACGLYHKMNGQN
K245-ac NRPLIRPkkRMIVSk
K246-ac RPLIRPkkRMIVSkR
K252-ac kkRMIVSkRAGTQCT
Y285 VCNACGLYFKLHQVN
F286 CNACGLYFKLHQVNR
T304 MRKDGIQTRNRKAsG
K308 GIQTRNRKAsGkGKK
S310-p QTRNRKAsGkGKKKR
K312-ac RNRKAsGkGKKKRGS
K314 RKAsGkGKKKRGSNL
K315 KAsGkGKKKRGSNLA
K316 AsGkGKKKRGSNLAG
S319 kGKKKRGSNLAGAGA
N320 GKKKRGSNLAGAGAA
A324 RGSNLAGAGAAEGPA
  rat

 
S26 VDSALVSSTSDSAGF
S49 DTASSSTSPNAATAA
S72 EAEAYRHSPVFQVYP
Y78 HSPVFQVYPLLNSME
S91 MEGIPGSSPYASWAY
A116 VCPSHEDAPSQTLED
T131 PDGKNNNTFLETLKT
K137 NTFLETLKTERLSPD
T138 TFLETLKTERLSPDL
S142 TLKTERLSPDLLTLG
Y163 LPVTSSAYGGADFPS
S178 PFFSPTGSPLSSAAY
S187 LSSAAYSSPKFHGSL
Y223 RRDRTGHYLCNACGL
Y231 LCNACGLYHKMNGQN
K245 NRPLIRPKKRMIVSK
K246 RPLIRPKKRMIVSKR
K252 KKRMIVSKRAGTQCT
Y285 VCNACGLYYKLHQVN
Y286 CNACGLYYKLHQVNR
T304 MRKDGIQTRNRKASG
K308 GIQTRNRKASGKGKK
S310 QTRNRKASGKGKKKR
K312 RNRKASGKGKKKRGS
K314 RKASGKGKKKRGSSL
K315 KASGKGKKKRGSSLA
K316 ASGKGKKKRGSSLAG
S319 KGKKKRGSSLAGAGA
S320 GKKKRGSSLAGAGAA
A324 RGSSLAGAGAAEGPA
  chicken

 
- gap
- gap
- gap
- gap
S49 YPPSGRVSLVPWADT
E72 VPPATQMEPPHYLEL
- gap
Q81 PHYLELLQPPRGSPP
P82 HYLELLQPPRGSPPH
S86 LLQPPRGSPPHPSSG
- gap
S100 GPLLPLSSGPPPCEA
- gap
Y129 RRDGTGHYLCNACGL
Y137 LCNACGLYHRLNGQN
K151 NRPLIRPKKRLLVSK
K152 RPLIRPKKRLLVSKR
K158 KKRLLVSKRAGTVCS
Y191 VCNACGLYYKLHQVN
Y192 CNACGLYYKLHQVNR
T210 MRKDGIQTRNRkVSS
K214-ac GIQTRNRkVSSkGkK
S216 QTRNRkVSSkGkKRR
K218-ac RNRkVSSkGkKRRPP
K220-ac RkVSSkGkKRRPPGG
K221 kVSSkGkKRRPPGGG
R222 VSSkGkKRRPPGGGN
P225 kGkKRRPPGGGNPSA
- gap
G227 kKRRPPGGGNPSATA
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