Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Belongs to the IL-1 family. Note: This description may include information from UniProtKB.
Protein type: Cytokine; Motility/polarity/chemotaxis
Molecular Function: copper ion binding; interleukin-1 receptor binding; cytokine activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of mitosis; cytokine and chemokine mediated signaling pathway; positive regulation of interleukin-2 biosynthetic process; germ cell programmed cell death; positive regulation of interleukin-6 production; positive regulation of JNK cascade; fever; positive regulation of stress-activated MAPK cascade; negative regulation of cell proliferation; positive regulation of angiogenesis; connective tissue replacement during inflammatory response; inflammatory response to antigenic stimulus; response to copper ion; positive regulation of protein secretion; positive regulation of cell division; regulation of actin cytoskeleton organization and biogenesis; keratinization; positive regulation of prostaglandin secretion; positive regulation of transcription from RNA polymerase II promoter; immune response; regulation of sensory perception of pain; inflammatory response; positive regulation of cytokine secretion
LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.