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IL1A (mouse)

Overview IL1A Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Belongs to the IL-1 family. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Cytokine Cellular Component: extracellular space; cell surface; extracellular region; cytosol Molecular Function: interleukin-1 receptor binding; copper ion binding; cytokine activity Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of mitosis; cytokine and chemokine mediated signaling pathway; positive regulation of interleukin-2 biosynthetic process; positive regulation of interleukin-6 production; positive regulation of JNK cascade; fever; positive regulation of stress-activated MAPK cascade; negative regulation of cell proliferation; positive regulation of angiogenesis; response to copper ion; keratinization; positive regulation of cell division; immune response; positive regulation of transcription from RNA polymerase II promoter; regulation of sensory perception of pain; inflammatory response; positive regulation of cytokine secretion Reference #:  P01582 (UniProtKB) Alt. Names/Synonyms: IL-1 alpha; Il-1a; Il1a; interleukin 1 alpha; Interleukin-1 alpha; OTTMUSP00000016430 Gene Symbols: Il1a Molecular weight: 31,023 Da Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states

Select Structure to View Below IL1A 1ITA - A=121-271 (human) 2ILA - A=117-271 (human) 2KKI - A=121-271 (human) 2L5X - A/D=121-271 (human)

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
1	0		S90-p	ILKKRRLsFSETFTE
0	1		S192	VTLKISDSQLFVSAQ

	human
S87	VLKKRRLSLSQSITD
T189-p	VILRISKtQLYVTAQ

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