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Protein Page:
IL1A (mouse)

Overview
IL1A Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells. Belongs to the IL-1 family. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Cytokine
Cellular Component: extracellular space; cell surface; plasma membrane; extracellular region; cytosol
Molecular Function: interleukin-1 receptor binding; copper ion binding; cytokine activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of mitosis; positive regulation of interleukin-2 biosynthetic process; cytokine and chemokine mediated signaling pathway; germ cell programmed cell death; positive regulation of interleukin-6 production; positive regulation of JNK cascade; fever; positive regulation of stress-activated MAPK cascade; negative regulation of cell proliferation; positive regulation of angiogenesis; response to copper ion; positive regulation of cell division; keratinization; positive regulation of prostaglandin secretion; immune response; positive regulation of transcription from RNA polymerase II promoter; regulation of sensory perception of pain; inflammatory response; positive regulation of cytokine secretion
Reference #:  P01582 (UniProtKB)
Alt. Names/Synonyms: IL-1 alpha; Il-1a; Il1a; interleukin 1 alpha; Interleukin-1 alpha; OTTMUSP00000016430
Gene Symbols: Il1a
Molecular weight: 31,023 Da
Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states
Select Structure to View Below

IL1A

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 S16-p EDLKNCYsENEDYsS
0 1 S22-p YsENEDYsSAIDHLS
0 1 T59 VSLRTSETSKMSNFT
0 1 S60 SLRTSETSKMSNFTF
0 1 T66 TSKMSNFTFKESRVT
1 0 S90-p ILKKRRLsFSETFTE
0 1 S115-p EETIQPRsAPYTYQS
0 1 S192 VTLKISDSQLFVSAQ
  human

 
S16 EDLKNCYSENEEDSS
S22 YSENEEDSSSIDHLS
T59-p VSLSISEtsKTSKLt
S60-p SLSISEtsKTSKLtF
T66-p tsKTSKLtFKESMVV
S87 VLKKRRLSLSQSITD
S113 EEIIKPRSAPFSFLS
T189-p VILRISKtQLYVTAQ
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