Home

GLUT4 (human)

Overview GLUT4 an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Its surface expression is regulated by insulin. Has two internalization sequences, a dileucine repeat present in the C-terminus and a FxxY motif in the amino-terminal end. Associates with an intracellular tubulo-vesicular compartment under low plasma conditions. The binding of insulin to the insulin receptor (a typosine kinase) leads to the rapid translocation of GLUT4 to the cell surface, increasing cellular glucose transport activity. Its translocation to the plasma membrane is also stimulated by exercise, but independent from insulin signaling. This insulin-independent pathway may be regulated by AMPK. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Transporter Cellular Component: multivesicular body; trans-Golgi network transport vesicle; membrane; clathrin-coated vesicle; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane; coated pit; vesicle membrane; sarcolemma; external side of plasma membrane Molecular Function: D-glucose transmembrane transporter activity; protein binding; glucose transmembrane transporter activity Biological Process: response to ethanol; cellular response to insulin stimulus; glucose import; hexose transport; carbohydrate metabolic process; brown fat cell differentiation; glucose transport; glucose homeostasis; transmembrane transport Reference #:  P14672 (UniProtKB) Alt. Names/Synonyms: Glucose transporter type 4, insulin-responsive; GLUT-4; GLUT4; GTR4; insulin-responsive glucose transporter type 4; SLC2A4; solute carrier family 2 (facilitated glucose transporter), member 4; Solute carrier family 2, facilitated glucose transporter member 4 Gene Symbols: SLC2A4 Molecular weight: 54,787 Da Basal Isoelectric point: 6.48  Predict pI for various phosphorylation states CST Pathways:  AMPK Signaling  |  Insulin Receptor Signaling  |  Warburg Effect

Select Structure to View Below GLUT4

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  DISEASE 125853 138190  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
activation: S274‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	2		Y56-p	QKVIEQSyNETWLGR
0	1		Y148	GRFLIGAYSGLTSGL
0	1		S149	RFLIGAYSGLTSGLV
0	1		T209	WPLLLGLTVLPALLQ
0	2		K261	SGVLAELKDEKRKLE
1	0		S274-p	LERERPLsLLQLLGs
0	1		S281-p	sLLQLLGsRTHRQPL
0	2		T486	ISAAFHRTPSLLEQE
2	2		S488	AAFHRTPSLLEQEVK
0	1		K495	SLLEQEVKPSTELEy
0	1		S497	LEQEVKPSTELEyLG
0	3		Y502-p	KPSTELEyLGPDEND

	mouse
Y56	QKVIEQSYNATWLGR
Y148-p	GRFLIGAysGLTSGL
S149-p	RFLIGAysGLTSGLV
T209-p	WPLLLALtVLPALLQ
K261-u	SDALAELkDEKRKLE
S274	LERERPMSLLQLLGS
S281	SLLQLLGSRTHRQPL
T486-p	ISAAFRRtPsLLEQE
S488-p	AAFRRtPsLLEQEVk
K495-u	sLLEQEVkPsTELEY
S497-p	LEQEVkPsTELEYLG
Y502	kPsTELEYLGPDEND

	rat
Y56	QKVIEQSYNATWLGR
Y148	GRFLIGAYSGLTSGL
S149	RFLIGAYSGLTSGLV
T209	WPLLLAITVLPALLQ
K261	SDALAELKDEKRKLE
S274	LERERPLSLLQLLGS
S281	SLLQLLGSRTHRQPL
T486	ISATFRRTPsLLEQE
S488-p	ATFRRTPsLLEQEVK
K495	sLLEQEVKPSTELEY
S497	LEQEVKPSTELEYLG
Y502	KPSTELEYLGPDEND

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.