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Protein Page:
GLUT4 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
GLUT4 an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. Its surface expression is regulated by insulin. Has two internalization sequences, a dileucine repeat present in the C-terminus and a FxxY motif in the amino-terminal end. Associates with an intracellular tubulo-vesicular compartment under low plasma conditions. The binding of insulin to the insulin receptor (a typosine kinase) leads to the rapid translocation of GLUT4 to the cell surface, increasing cellular glucose transport activity. Its translocation to the plasma membrane is also stimulated by exercise, but independent from insulin signaling. This insulin-independent pathway may be regulated by AMPK. Note: This description may include information from UniProtKB.
Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass
Cellular Component: multivesicular body; trans-Golgi network transport vesicle; clathrin-coated vesicle; membrane; perinuclear region of cytoplasm; integral to plasma membrane; plasma membrane; endomembrane system; coated pit; vesicle membrane; sarcolemma; external side of plasma membrane
Molecular Function: D-glucose transmembrane transporter activity; protein binding; glucose transmembrane transporter activity
Biological Process: amylopectin biosynthetic process; response to ethanol; cellular response to insulin stimulus; hexose transport; glucose import; carbohydrate metabolic process; brown fat cell differentiation; glucose transport; glucose homeostasis; transmembrane transport
Reference #:  P14672 (UniProtKB)
Alt. Names/Synonyms: Glucose transporter type 4, insulin-responsive; GLUT-4; GLUT4; GTR4; insulin-responsive glucose transporter type 4; SLC2A4; solute carrier family 2 (facilitated glucose transporter), member 4; Solute carrier family 2, facilitated glucose transporter member 4
Gene Symbols: SLC2A4
Molecular weight: 54,787 Da
Basal Isoelectric point: 6.48  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Insulin Receptor Signaling  |  Warburg Effect
Select Structure to View Below

GLUT4

Protein Structure Not Found.


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Sites Implicated In
activity, induced: S274‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y56-p QKVIEQSyNETWLGR
0 2 K261 SGVLAELKDEKRKLE
1 0 S274-p LERERPLsLLQLLGS
0 2 T486 ISAAFHRTPsLLEQE
2 2 S488-p AAFHRTPsLLEQEVK
0 1 K495 sLLEQEVKPSTELEy
0 1 S497 LEQEVKPSTELEyLG
0 3 Y502-p KPSTELEyLGPDEND
  mouse

 
Y56 QKVIEQSYNATWLGR
K261-u SDALAELkDEKRKLE
S274 LERERPMSLLQLLGS
T486-p ISAAFRRtPsLLEQE
S488-p AAFRRtPsLLEQEVk
K495-u sLLEQEVkPsTELEY
S497-p LEQEVkPsTELEYLG
Y502 kPsTELEYLGPDEND
  rat

 
Y56 QKVIEQSYNATWLGR
K261 SDALAELKDEKRKLE
S274 LERERPLSLLQLLGS
T486 ISATFRRTPsLLEQE
S488-p ATFRRTPsLLEQEVK
K495 sLLEQEVKPSTELEY
S497 LEQEVKPSTELEYLG
Y502 KPSTELEYLGPDEND
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