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Protein Page:
TNF-R1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TNF-R1 Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate- specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. Binding of TNF to the extracellular domain leads to homotrimerization. The aggregated death domains provide a novel molecular interface that interacts specifically with the death domain of TRADD. Various TRADD-interacting proteins such as TRAFS, RIPK1 and possibly FADD, are recruited to the complex by their association with TRADD. This complex activates at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4, BRE, FEM1B, GRB2, SQSTM1 and TRPC4AP. Interacts with HCV core protein. Interacts with human cytomegalovirus/HHV-5 protein UL138. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Cellular Component: Golgi membrane; extracellular space; cell surface; axon; integral to plasma membrane; extracellular region; plasma membrane; nucleus; receptor complex; lipid raft
Molecular Function: protein binding; tumor necrosis factor receptor activity; protease binding; protein complex binding; tumor necrosis factor binding
Biological Process: response to alkaloid; viral reproduction; apoptosis; protein heterooligomerization; response to lipopolysaccharide; tumor necrosis factor-mediated signaling pathway; negative regulation of interleukin-6 production; tetrapyrrole metabolic process; inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein import into nucleus, translocation; cytokine and chemokine mediated signaling pathway; response to amino acid stimulus; positive regulation of tumor necrosis factor production; prostaglandin metabolic process; positive regulation of angiogenesis; positive regulation of tyrosine phosphorylation of Stat1 protein; response to ethanol; induction of apoptosis via death domain receptors; DNA damage response, signal transduction resulting in induction of apoptosis; negative regulation of inflammatory response; defense response to bacterium; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; positive regulation of inflammatory response; negative regulation of apoptosis
Reference #:  P19438 (UniProtKB)
Alt. Names/Synonyms: CD120a; FPF; MGC19588; p55; p55-R; p60; TBP1; TBPI; TNF-R; TNF-R-I; TNF-R1; TNF-R55; TNF-RI; TNFAR; TNFR-I; TNFR1; TNFR55; TNFR60; TNFRSF1A; TNR1A; tumor necrosis factor binding protein 1; Tumor necrosis factor receptor 1; tumor necrosis factor receptor 1A isoform beta; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor superfamily member 1A, membrane form; tumor necrosis factor receptor superfamily, member 1A; tumor necrosis factor receptor type 1; Tumor necrosis factor receptor type I; tumor necrosis factor-alpha receptor; Tumor necrosis factor-binding protein 1
Gene Symbols: TNFRSF1A
Molecular weight: 50,495 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  NF-kB Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TNF-R1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S86-p TDCRECEsGSFtASE
0 1 T90-p ECEsGSFtASENHLR
0 1 T118-p QVEISSCtVDRDTVC
0 1 R238 GLMYRYQRWKSKLYS
0 1 K240 MYRYQRWKSKLYSIV
2 0 A268 GTTTKPLAPNPSFSP
2 0 - gap
2 0 S274 LAPNPSFSPTPGFTP
1 0 V288 PTLGFSPVPSSTFTS
1 0 F293 SPVPSSTFTSSSTYT
1 0 T298 STFTSSSTYTPGDCP
2 0 - gap
0 10 Y318-p RREVAPPyQGADPIL
0 1 T353-p HKPQSLDtDDPATLy
1 1 Y360-p tDDPATLyAVVENVP
1 0 S381-p FVRRLGLsDHEIDRL
1 6 Y401-p RCLREAQysMLAtWR
0 1 S402-p CLREAQysMLAtWRR
0 1 T406-p AQysMLAtWRRRTPR
0 3 T417-p RTPRREAtLELLGRV
  mouse

 
K86 TVCRECEKGTFTASQ
T90 ECEKGTFTASQNYLR
Q118 QVEISPCQADKDTVC
R239-m1 SLMCRYPrWrPEVYS
R241-m1 MCRYPrWrPEVYSII
T265-p EKAGKPLtPAPsPAF
S269-p KPLtPAPsPAFsPTS
S273-p PAPsPAFsPTSGFNP
T286-p NPTLGFStPGFSsPV
S291-p FStPGFSsPVSStPI
T296-p FSsPVSStPIsPIFG
S299-p PVSStPIsPIFGPSN
T319 PVSEVVPTQGADPLL
N353 AHPQRPDNADLAILY
Y360 NADLAILYAVVDGVP
S381 FMRFMGLSEHEIERL
Y401 RCLREAQYSMLEAWR
S402 CLREAQYSMLEAWRR
A406 AQYSMLEAWRRRTPR
T417 RTPRHEDTLEVVGLV
  rat

 
K86 TVCEVCDKGTFTASQ
T90 VCDKGTFTASQNHVR
K118 QVEISPCKADMDTVC
Q238 SLLCRYPQWRPRVYS
R240 LCRYPQWRPRVYSII
T268 GIVTKPLTPASIPAF
I272 KPLTPASIPAFSPNP
S276 PASIPAFSPNPGFNP
T290 PTLGFSTTPRFSHPV
H295 STTPRFSHPVSSTPI
T300 FSHPVSSTPISPVFG
S303 PVSSTPISPVFGPSN
T324 PVREVVPTQGADPLL
T360 AQPQRLDTADPAMLY
Y367 TADPAMLYAVVDGVP
S388 FMRLLGLSEHEIERL
Y408 RCLREAHYSMLEAWR
S409 CLREAHYSMLEAWRR
A413 AHYSMLEAWRRRTPR
T424 RTPRHEATLDVVGRV
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