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Protein Page:
Stargazin (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Stargazin Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with GRIA1. Brain. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, calcium
Cellular Component: plasma membrane; voltage-gated calcium channel complex
Molecular Function: voltage-gated calcium channel activity; ionotropic glutamate receptor binding; protein binding
Biological Process: membrane depolarization; synaptic transmission; transport; membrane hyperpolarization; transmission of nerve impulse; neuromuscular junction development
Reference #:  Q9Y698 (UniProtKB)
Alt. Names/Synonyms: CACNG2; calcium channel, voltage-dependent, gamma subunit 2; CCG2; MGC138502; MGC138504; Neuronal voltage-gated calcium channel gamma-2 subunit; stargazin; Voltage-dependent calcium channel gamma-2 subunit
Gene Symbols: CACNG2
Molecular weight: 35,966 Da
Basal Isoelectric point: 9.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Stargazin

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S125-p GGLCIAAsEFYKTRH
0 79 Y217 ATARATDYLQASAIT
1 3 S221 ATDYLQASAITRIPs
3 3 S228-p SAITRIPsyRYRYQR
0 1 Y229-p AITRIPsyRYRYQRR
2 0 S237 RYRYQRRSRssSRST
4 0 S239-p RYQRRSRssSRSTEP
4 0 S240-p YQRRSRssSRSTEPS
2 0 S241 QRRSRssSRSTEPSH
2 0 S243 RSRssSRSTEPSHsR
2 0 S247 sSRSTEPSHsRDASP
2 2 S249-p RSTEPSHsRDASPVG
2 5 S253 PSHsRDASPVGIKGF
0 8 Y271 PSTEISMYTLSRDPL
0 1 T283 DPLKAATTPTATYNS
0 1 T287 AATTPTATYNSDRDN
0 5 Y288 ATTPTATYNSDRDNS
0 1 K305 QVHNCIQKENKDSLH
3 0 T321 NTANRRTTPV_____
  mouse

 
S125 GGLCIAASEFYKTRH
Y217-p ATARATDyLQAsAIT
S221-p ATDyLQAsAITRIPs
S228-p sAITRIPsYRYRYQR
Y229 AITRIPsYRYRYQRR
S237-p RYRYQRRsRsssRsT
S239-p RYQRRsRsssRsTEP
S240-p YQRRsRsssRsTEPs
S241-p QRRsRsssRsTEPsH
S243-p RsRsssRsTEPsHsR
S247-p ssRsTEPsHsRDAsP
S249-p RsTEPsHsRDAsPVG
S253-p PsHsRDAsPVGVKGF
Y271-p PSTEISMyTLSRDPL
T283-p DPLKAATtPTAtyNS
T287-p AATtPTAtyNSDRDN
Y288-p ATtPTAtyNSDRDNS
K305-ub QVHNCIQkDSKDSLH
T321-p NTANRRTtPV_____
  rat

 
S125 GGLCIAASEFYKTRH
Y217-p ATARATDyLQASAIT
S221 ATDyLQASAITRIPs
S228-p SAITRIPsYRYRYQR
Y229 AITRIPsYRYRYQRR
S237 RYRYQRRSRssSRST
S239-p RYQRRSRssSRSTEP
S240-p YQRRSRssSRSTEPS
S241 QRRSRssSRSTEPSH
S243 RSRssSRSTEPSHSR
S247 sSRSTEPSHSRDASP
S249 RSTEPSHSRDASPVG
S253 PSHSRDASPVGVKGF
Y271-p PSTEISMyTLSRDPL
T283 DPLKAATTPTATyNS
T287 AATTPTATyNSDRDN
Y288-p ATTPTATyNSDRDNS
K305 QVHNCIQKDSKDSLH
T321-p NTANRRTtPV_____
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