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Protein Page:
CD46 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CD46 Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46. Defects in CD46 are a cause of susceptibility to hemolytic uremic syndrome atypical type 2 (AHUS2). An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype. Patients with CD46 mutations seem to have an overall better prognosis compared to patients carrying CFH mutations. 16 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Membrane protein, integral; Cell surface
Cellular Component: Golgi apparatus; inner acrosomal membrane; cell surface; integral to plasma membrane; basolateral plasma membrane; plasma membrane
Molecular Function: complement binding; protein binding; cadherin binding; receptor activity
Biological Process: positive regulation of memory T cell differentiation; adaptive immune response; positive regulation of regulatory T cell differentiation; regulation of Notch signaling pathway; viral reproduction; negative regulation of complement activation; single fertilization; T cell mediated immunity; regulation of complement activation; interleukin-10 production; innate immune response; positive regulation of T cell proliferation; proteolysis; complement activation, classical pathway; positive regulation of interleukin-10 production
Reference #:  P15529 (UniProtKB)
Alt. Names/Synonyms: AHUS2; antigen identified by monoclonal antibody TRA-2-10; CD46; CD46 antigen, complement regulatory protein; CD46 molecule, complement regulatory protein; complement membrane cofactor protein; MCP; measles virus receptor; Membrane cofactor protein; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); MGC26544; MIC10; TLX; TRA2.10; trophoblast leucocyte common antigen; Trophoblast leukocyte common antigen
Gene Symbols: CD46
Molecular weight: 43,747 Da
Basal Isoelectric point: 6.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CD46

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T303-p ALSHSVStSSTTKSP
0 1 T320-p SASGPRPtYKPPVSN
0 3 K375-ub YLQRRKKkGTyLTDE
0 6 Y378-p RRKKkGTyLTDETHR
0 1 S391-p HREVKFTsL______
0 3 - gap
1 1012 - gap
0 59 - gap
0 593 - gap
0 5 - gap
0 60 - gap
0 1 - gap
0 1 - gap
  CD46 iso4  
- gap
T290 CLKGPRPTYKPPVSN
K345 YLQRRKKKGkADGGA
- gap
- gap
K347-ub QRRKKKGkADGGAEy
Y354-p kADGGAEyAtyQtkS
T356-p DGGAEyAtyQtkStt
Y357-p GGAEyAtyQtkSttP
T359-p AEyAtyQtkSttPAE
K360-ub EyAtyQtkSttPAEQ
T362-p AtyQtkSttPAEQRG
T363-p tyQtkSttPAEQRG_
  CD46 iso11  
T288 PKCLKVSTSSTTKSP
T305 SASGPRPTYKPPVSN
K360 YLQRRKKKGTYLTDE
Y363 RRKKKGTYLTDETHR
S376 HREVKFTSL______
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  CD46 iso12  
- gap
T290 CLKGPRPTYKPPVSN
K345 YLQRRKKKGTYLTDE
Y348 RRKKKGTYLTDETHR
S361 HREVKFTSL______
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  mouse

 
- gap
T301 CLKGPRPTHPTKPPV
T359 CFEHRKKTNVSAAR_
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
T359 CFEHRKKTNVSAAR_
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