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Protein Page:
ID2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ID2 ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression. Heterodimer with other HLH proteins. Interacts with GATA4, IFI204 and NKX2-5. Interacts with NR0B2. Highly expressed in early fetal tissues, including those of the central nervous system. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor; DNA binding protein
Chromosomal Location of Human Ortholog: 2p25
Cellular Component: centrosome; protein complex; cytoplasm; nucleolus; cytosol; chromatin; nucleus
Molecular Function: protein dimerization activity; protein binding
Biological Process: regulation of lipid metabolic process; positive regulation of smooth muscle cell proliferation; multicellular organismal development; positive regulation of transcription, DNA-dependent; cell maturation; negative regulation of transcription from RNA polymerase II promoter; entrainment of circadian clock by photoperiod; locomotor rhythm; natural killer cell differentiation; embryonic digestive tract morphogenesis; negative regulation of osteoblast differentiation; circadian regulation of gene expression; positive regulation of macrophage differentiation; oligodendrocyte development; positive regulation of astrocyte differentiation; Peyer's patch development; negative regulation of B cell differentiation; olfactory bulb development; positive regulation of erythrocyte differentiation; negative regulation of transcription factor activity; neuron fate commitment; mammary gland epithelial cell proliferation; positive regulation of cell cycle; enucleate erythrocyte differentiation; regulation of circadian rhythm; negative regulation of DNA binding; negative regulation of oligodendrocyte differentiation; negative regulation of neuron differentiation; positive regulation of fat cell differentiation; negative regulation of transcription, DNA-dependent; metanephros development; positive regulation of blood pressure
Reference #:  Q02363 (UniProtKB)
Alt. Names/Synonyms: BHLHB26; cell growth-inhibiting gene 8; Class B basic helix-loop-helix protein 26; DNA-binding protein inhibitor ID-2; DNA-binding protein inhibitor ID2; GIG8; helix-loop-helix protein ID2; ID2; ID2A; ID2H; inhibitor of differentiation 2; Inhibitor of DNA binding 2; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; MGC26389
Gene Symbols: ID2
Molecular weight: 14,917 Da
Basal Isoelectric point: 7.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ID2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
2 1 S5 ___MKAFSPVRSVRk
0 1 K12-ub SPVRSVRkNsLSDHS
0 5 S14-p VRSVRkNsLSDHSLG
0 1 S25 HSLGISRSKTPVDDP
0 1 Y43-p LYNMNDCysKLKELV
0 1 S44-p YNMNDCysKLKELVP
  mouse

 
S5-p ___MKAFsPVRSVRK
K12 sPVRSVRKNsLSDHS
S14-p VRSVRKNsLSDHSLG
S25-p HSLGISRsKTPVDDP
Y43 LYNMNDCYSKLKELV
S44 YNMNDCYSKLKELVP
  rat

 
S5-p ___MKAFsPVRSVRK
K12 sPVRSVRKNsLSDHS
S14-p VRSVRKNsLSDHSLG
S25 HSLGISRSKTPVDDP
Y43 LYNMNDCYSKLKELV
S44 YNMNDCYSKLKELVP
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