ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression. Heterodimer with other HLH proteins. Interacts with GATA4, IFI204 and NKX2-5. Interacts with NR0B2. Highly expressed in early fetal tissues, including those of the central nervous system. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription, coactivator/corepressor
Cellular Component: protein complex; cytoplasm; nucleolus; chromatin; cytosol; nucleus
Molecular Function: protein dimerization activity; protein binding
Biological Process: regulation of lipid metabolic process; positive regulation of transcription, DNA-dependent; multicellular organismal development; positive regulation of smooth muscle cell proliferation; cell maturation; negative regulation of transcription from RNA polymerase II promoter; natural killer cell differentiation; embryonic digestive tract morphogenesis; negative regulation of osteoblast differentiation; oligodendrocyte development; positive regulation of macrophage differentiation; positive regulation of astrocyte differentiation; negative regulation of B cell differentiation; Peyer's patch development; positive regulation of erythrocyte differentiation; negative regulation of transcription factor activity; olfactory bulb development; neuron fate commitment; mammary gland epithelial cell proliferation; positive regulation of cell cycle; enucleate erythrocyte differentiation; negative regulation of DNA binding; negative regulation of oligodendrocyte differentiation; negative regulation of neuron differentiation; positive regulation of fat cell differentiation; entrainment of circadian clock; negative regulation of transcription, DNA-dependent; metanephros development; positive regulation of blood pressure
Alt. Names/Synonyms: BHLHB26; cell growth-inhibiting gene 8; Class B basic helix-loop-helix protein 26; DNA-binding protein inhibitor ID-2; DNA-binding protein inhibitor ID2; GIG8; helix-loop-helix protein ID2; ID2; ID2A; ID2H; inhibitor of differentiation 2; Inhibitor of DNA binding 2; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; MGC26389
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.