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ID2 (human)

Overview ID2 ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression. Heterodimer with other HLH proteins. Interacts with GATA4, IFI204 and NKX2-5. Interacts with NR0B2. Highly expressed in early fetal tissues, including those of the central nervous system. Note: This description may include information from UniProtKB. Protein type: Transcription, coactivator/corepressor; DNA binding protein Cellular Component: protein complex; cytoplasm; nucleolus; cytosol; chromatin; nucleus Molecular Function: protein dimerization activity; protein binding Biological Process: regulation of lipid metabolic process; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; multicellular organismal development; cell maturation; negative regulation of transcription from RNA polymerase II promoter; embryonic digestive tract morphogenesis; natural killer cell differentiation; negative regulation of osteoblast differentiation; oligodendrocyte development; positive regulation of macrophage differentiation; positive regulation of astrocyte differentiation; Peyer's patch development; negative regulation of B cell differentiation; negative regulation of transcription factor activity; positive regulation of erythrocyte differentiation; olfactory bulb development; neuron fate commitment; mammary gland epithelial cell proliferation; positive regulation of cell cycle; enucleate erythrocyte differentiation; negative regulation of DNA binding; negative regulation of oligodendrocyte differentiation; negative regulation of neuron differentiation; positive regulation of fat cell differentiation; entrainment of circadian clock; negative regulation of transcription, DNA-dependent; metanephros development; positive regulation of blood pressure Reference #:  Q02363 (UniProtKB) Alt. Names/Synonyms: BHLHB26; cell growth-inhibiting gene 8; Class B basic helix-loop-helix protein 26; DNA-binding protein inhibitor ID-2; DNA-binding protein inhibitor ID2; GIG8; helix-loop-helix protein ID2; ID2; ID2A; ID2H; inhibitor of differentiation 2; Inhibitor of DNA binding 2; inhibitor of DNA binding 2, dominant negative helix-loop-helix protein; MGC26389 Gene Symbols: ID2 Molecular weight: 14,917 Da Basal Isoelectric point: 7.82  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below ID2 4AYA - A/B=1-82 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
2	1		S5	___MKAFSPVRSVRk
0	1		K12-u	SPVRSVRkNsLSDHS
0	2		S14-p	VRSVRkNsLSDHSLG
0	1		S25	HSLGISRSKTPVDDP
0	1		Y43-p	LYNMNDCysKLKELV
0	1		S44-p	YNMNDCysKLKELVP

	mouse
S5-p	___MKAFsPVRSVRK
K12	sPVRSVRKNsLSDHS
S14-p	VRSVRKNsLSDHSLG
S25-p	HSLGISRsKTPVDDP
Y43	LYNMNDCYSKLKELV
S44	YNMNDCYSKLKELVP

	rat
S5-p	___MKAFsPVRSVRK
K12	sPVRSVRKNSLSDHS
S14	VRSVRKNSLSDHSLG
S25	HSLGISRSKTPVDDP
Y43	LYNMNDCYSKLKELV
S44	YNMNDCYSKLKELVP

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