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Shc3 (human)

Overview Shc3 an adapter protein containing an SH2 and a PID domain. Couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons and the regulation of NMDA receptor function in the hippocampus. May modulate hippocampal synaptic plasticity underlying learning and memory. Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors. Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. A switch from Shc1 to Shc3 occurs during maturation of neuronal precursors to postmitotic neurons. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB. Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis Cellular Component: cytosol Molecular Function: signal transducer activity; protein binding Biological Process: epidermal growth factor receptor signaling pathway; synaptic transmission, glutamatergic; learning and/or memory; central nervous system development; nerve growth factor receptor signaling pathway; Ras protein signal transduction; insulin receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway Reference #:  Q92529 (UniProtKB) Alt. Names/Synonyms: N-Shc; Neuronal Shc; NSHC; Protein Rai; RAI; SH2 domain protein C3; SHC (Src homology 2 domain containing) transforming protein 3; SHC-transforming protein 3; SHC-transforming protein C; SHC3; SHCC; src homology 2 domain-containing transforming protein C3; Src homology 2 domain-containing-transforming protein C3 Gene Symbols: SHC3 Molecular weight: 64,056 Da Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Insulin Receptor Signaling  |  Jak/Stat/IL-6 Signaling  |  MAPK/Erk in Growth and Differentiation  |  SAPK/JNK Signaling Cascades  |  TGF-ß Signaling

Select Structure to View Below Shc3

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	Sites Implicated In
apoptosis, inhibited: Y341‑p, Y342‑p, Y424‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	2		Y46-p	ATPAAAPyLVSGEAL
0	1		S97	ERAGARLSGSCSAPS
0	1		S101	ARLSGSCSAPSLAAP
0	1		S114	APDGSAPSAPRAPAM
0	1		-	gap
0	1		S122	APRAPAMSAARKGRP
0	1		S210-p	KPPSKMLsSILGKSN
0	1		S224-p	NLQFAGMsISLTIST
0	2		Y308-p	FELRFKQyLQCPTKI
0	2		S324	ALHDRMQSLDEPWTE
0	2		S337-p	TEEEGDGsDHPyyNS
3	3		Y341-p	GDGsDHPyyNSIPSK
3	10		Y342-p	DGsDHPyyNSIPSKM
1	2		Y379-p	FAGKEQTyyQGRHLG
1	0		Y380-p	AGKEQTyyQGRHLGD
0	2		S402	QTPLRQGSSDIysTP
1	23		Y406-p	RQGSSDIysTPEGKL
0	1		S407-p	QGSSDIysTPEGKLH
3	0		Y424-p	PTGEAPTyVNTQQIP
0	7		S474-p	PVLSKAAsVECIsPV
0	7		S479-p	AAsVECIsPVsPRAP
0	2		S482-p	VECIsPVsPRAPDAK

	Shc3 iso2
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
S87	KPPSKMLSSILGKSN
S101	NLQFAGMSISLTIST
Y185	FELRFKQYLQCPTKI
S201	ALHDRMQSLDEPWTE
S214	TEEEGDGSDHPyyNS
Y218-p	GDGSDHPyyNSIPSK
Y219-p	DGSDHPyyNSIPSKM
Y256-p	FAGKEQTyyQGRHLG
Y257-p	AGKEQTyyQGRHLGD
S279	QTPLRQGSSDIySTP
Y283-p	RQGSSDIySTPEGKL
S284	QGSSDIySTPEGKLH
Y301-p	PTGEAPTyVNTQQIP
S351	PVLSKAASVECISPV
S356	AASVECISPVSPRAP
S359	VECISPVSPRAPDAK

	mouse
-	gap
-	gap
-	gap
-	gap
-	gap
S2	______MSATRKSRA
S90	KPPSKMLSSILGKSN
S104	NLQFAGMSISLTIST
Y188	FELRFKQYLQCPSKV
S204-p	ALQDRMQsLDEPWTE
P217	TEEEGDGPDHPYYNS
Y221	GDGPDHPYYNSVPTK
Y222	DGPDHPYYNSVPTKM
Y259-p	FAGKEQTyYQGRHLG
Y260	AGKEQTyYQGRHLGD
S282-p	RAPTRQGsLDIYSTA
Y286	RQGsLDIYSTAEGKT
S287	QGsLDIYSTAEGKTH
Y304	PVGETPTYVNTQPVP
S354-p	PMLSKAAsVECIsPV
S359-p	AAsVECIsPVtPRAP
T362-p	VECIsPVtPRAPDAR

	rat
Y43	AEPAASPYLVSGEAL
S94-p	ERAGARLsGSCsAPS
S98-p	ARLsGSCsAPSLAAP
T111-p	APDGGSAtPGSRAPA
S120-p	GSRAPAAsMsATRKS
S122-p	RAPAAsMsATRKSRA
S210	KPPSKMLSSILGKSN
S224	NLQFAGMSISLTIST
Y308	FELRFKQYLQCPSKI
S324	ALQDRMQSLDEPWTE
P337	TEEEGDGPDHPyyNS
Y341-p	GDGPDHPyyNSVPNK
Y342-p	DGPDHPyyNSVPNKM
Y379	FSGKEQTYYQGRHLG
Y380	SGKEQTYYQGRHLGD
S402	RAPTRQGSLDIySTP
Y406-p	RQGSLDIySTPEGKA
S407	QGSLDIySTPEGKAH
Y424	PVGETPTYVNTQPVP
S474	PVLSKAASVECISPV
S479	AASVECISPVTPRAP
T482	VECISPVTPRAPDAK

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