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Protein Page:
Shc3 (human)

Overview
Shc3 an adapter protein containing an SH2 and a PID domain. Couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons and the regulation of NMDA receptor function in the hippocampus. May modulate hippocampal synaptic plasticity underlying learning and memory. Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors. Mainly expressed in brain. Hardly detectable in other tissues, except in pancreas. Highly expressed in the cerebral cortex, frontal and temporal lobes, occipital pole, hippocampus, caudate nucleus and amygdala. Expressed at low level in the cerebellum, medulla and spinal cord. A switch from Shc1 to Shc3 occurs during maturation of neuronal precursors to postmitotic neurons. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Cellular Component: cytosol
Molecular Function: protein binding; signal transducer activity
Biological Process: epidermal growth factor receptor signaling pathway; synaptic transmission, glutamatergic; learning and/or memory; central nervous system development; nerve growth factor receptor signaling pathway; Ras protein signal transduction; insulin receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q92529 (UniProtKB)
Alt. Names/Synonyms: N-Shc; Neuronal Shc; NSHC; Protein Rai; RAI; SH2 domain protein C3; SHC (Src homology 2 domain containing) transforming protein 3; SHC-transforming protein 3; SHC-transforming protein C; SHC3; SHCC; src homology 2 domain-containing transforming protein C3; Src homology 2 domain-containing-transforming protein C3
Gene Symbols: SHC3
Molecular weight: 64,056 Da
Basal Isoelectric point: 8.57  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Insulin Receptor Signaling  |  SAPK/JNK Signaling Cascades  |  TGF-ß Signaling
Select Structure to View Below

Shc3

Protein Structure Not Found.


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Sites Implicated In
apoptosis, inhibited: Y341‑p, Y342‑p, Y424‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 2 Y46-p ATPAAAPyLVSGEAL
0 1 S97 ERAGARLSGSCSAPS
0 1 S101 ARLSGSCSAPSLAAP
0 1 S114 APDGSAPSAPRAPAM
0 1 - gap
0 1 S122 APRAPAMSAARKGRP
0 1 S210-p KPPSKMLsSILGKSN
0 1 S224-p NLQFAGMsISLTIST
0 2 Y308-p FELRFKQyLQCPTKI
0 2 S324-p ALHDRMQsLDEPWTE
0 2 S337-p TEEEGDGsDHPyyNS
3 3 Y341-p GDGsDHPyyNSIPSK
3 10 Y342-p DGsDHPyyNSIPSKM
1 2 Y379-p FAGKEQTyyQGRHLG
1 0 Y380-p AGKEQTyyQGRHLGD
0 2 S402 QTPLRQGSSDIysTP
1 23 Y406-p RQGSSDIysTPEGKL
0 1 S407-p QGSSDIysTPEGKLH
3 0 Y424-p PTGEAPTyVNTQQIP
0 7 S474-p PVLSKAAsVECIsPV
0 7 S479-p AAsVECIsPVsPRAP
0 2 S482-p VECIsPVsPRAPDAK
  Shc3 iso2  
- gap
- gap
- gap
- gap
- gap
- gap
S87 KPPSKMLSSILGKSN
S101 NLQFAGMSISLTIST
Y185 FELRFKQYLQCPTKI
S201 ALHDRMQSLDEPWTE
S214 TEEEGDGSDHPyyNS
Y218-p GDGSDHPyyNSIPSK
Y219-p DGSDHPyyNSIPSKM
Y256-p FAGKEQTyyQGRHLG
Y257-p AGKEQTyyQGRHLGD
S279 QTPLRQGSSDIySTP
Y283-p RQGSSDIySTPEGKL
S284 QGSSDIySTPEGKLH
Y301-p PTGEAPTyVNTQQIP
S351 PVLSKAASVECISPV
S356 AASVECISPVSPRAP
S359 VECISPVSPRAPDAK
  mouse

 
- gap
- gap
- gap
- gap
- gap
S2 ______MSATRKSRA
S90 KPPSKMLSSILGKSN
S104 NLQFAGMSISLTIST
Y188 FELRFKQYLQCPSKV
S204-p ALQDRMQsLDEPWTE
P217 TEEEGDGPDHPYYNS
Y221 GDGPDHPYYNSVPTK
Y222 DGPDHPYYNSVPTKM
Y259-p FAGKEQTyYQGRHLG
Y260 AGKEQTyYQGRHLGD
S282-p RAPTRQGsLDIYSTA
Y286 RQGsLDIYSTAEGKT
S287 QGsLDIYSTAEGKTH
Y304 PVGETPTYVNTQPVP
S354-p PMLSKAAsVECIsPV
S359-p AAsVECIsPVtPRAP
T362-p VECIsPVtPRAPDAR
  rat

 
Y43 AEPAASPYLVSGEAL
S94-p ERAGARLsGSCsAPS
S98-p ARLsGSCsAPSLAAP
T111-p APDGGSAtPGSRAPA
S120-p GSRAPAAsMsATRKS
S122-p RAPAAsMsATRKSRA
S210 KPPSKMLSSILGKSN
S224 NLQFAGMSISLTIST
Y308 FELRFKQYLQCPSKI
S324 ALQDRMQSLDEPWTE
P337 TEEEGDGPDHPyyNS
Y341-p GDGPDHPyyNSVPNK
Y342-p DGPDHPyyNSVPNKM
Y379 FSGKEQTYYQGRHLG
Y380 SGKEQTYYQGRHLGD
S402 RAPTRQGSLDIySTP
Y406-p RQGSLDIySTPEGKA
S407 QGSLDIySTPEGKAH
Y424 PVGETPTYVNTQPVP
S474 PVLSKAASVECISPV
S479 AASVECISPVTPRAP
T482 VECISPVTPRAPDAK
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