a multifunctional type I transmembrane protein receptor that binds insulin-like growth factor 2 at the cell surface and mannose-6-phosphate-tagged proteins in the trans-Golgi network. Also known as the cation-independent mannose-6 phosphate (M6P) receptor. Clears IGF2 from the cell surface to attenuate signaling, and transports M6P-tagged lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. M6P-tagged lysosomal enzymes bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Belongs to the MRL1/IGF2R family. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Vesicle protein; Membrane protein, integral
Chromosomal Location of Human Ortholog: 6q26
Cellular Component: extracellular space; trans-Golgi network transport vesicle; clathrin coat; cell surface; membrane; lysosomal membrane; integral to plasma membrane; nuclear envelope lumen; perinuclear region of cytoplasm; endocytic vesicle; late endosome; endosome
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.