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Protein Page:
IGF2R (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
IGF2R a multifunctional type I transmembrane protein receptor that binds insulin-like growth factor 2 at the cell surface and mannose-6-phosphate-tagged proteins in the trans-Golgi network. Also known as the cation-independent mannose-6 phosphate (M6P) receptor. Clears IGF2 from the cell surface to attenuate signaling, and transports M6P-tagged lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. M6P-tagged lysosomal enzymes bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Belongs to the MRL1/IGF2R family. Note: This description may include information from UniProtKB.
Protein type: Vesicle protein; Receptor, misc.; Membrane protein, integral
Cellular Component: extracellular space; trans-Golgi network transport vesicle; cell surface; clathrin coat; integral to plasma membrane; endocytic vesicle; lysosomal membrane; nuclear envelope lumen; perinuclear region of cytoplasm; late endosome; endosome
Molecular Function: identical protein binding; mannose binding; retinoic acid binding; transporter activity; phosphoprotein binding; G-protein alpha-subunit binding; receptor activity; insulin-like growth factor II binding; insulin-like growth factor receptor activity; G-protein coupled receptor activity; protein binding; enzyme binding; glycoprotein binding
Biological Process: receptor-mediated endocytosis; organ regeneration; response to retinoic acid; insulin-like growth factor receptor signaling pathway; positive regulation of apoptosis; spermatogenesis; signal transduction; liver development; post-embryonic development
Reference #:  P11717 (UniProtKB)
Alt. Names/Synonyms: 300 kDa mannose 6-phosphate receptor; cation-independent mannose-6 phosphate receptor; Cation-independent mannose-6-phosphate receptor; CD222; CI Man-6-P receptor; CI-MPR; CIMPR; IGF-II receptor; IGF2R; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; M6P-R; M6P/IGF2 receptor; M6P/IGF2R; M6PR; MPR 300; MPR1; MPRI
Gene Symbols: IGF2R
Molecular weight: 274,375 Da
Basal Isoelectric point: 5.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IGF2R

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T296-p PSERREGtIPKLTAK
0 2 Y700-p LSNAKLSyyDGMIQL
0 2 Y701-p SNAKLSyyDGMIQLN
0 2 Y709-p DGMIQLNyRGGTPYN
0 1 T1107-p STVRKPWtAVDTSVD
0 1 T1397 NWEAITGTGDPEHYL
0 1 P1400 AITGTGDPEHYLINV
0 1 T1828-p STSTFKVtRDsRTYS
0 1 S1831-p TFKVtRDsRTYSVGV
0 1 T2002-p KFVQKHKtYDLRLLS
0 2 S2346-p LTTCCRRssNVSYky
0 25 S2347-p TTCCRRssNVSYkys
0 1 K2352-a RssNVSYkysKVNKE
0 2 Y2353-p ssNVSYkysKVNKEE
0 2 S2354-p sNVSYkysKVNKEEE
0 2 T2362-p KVNKEEEtDENETEW
0 3 K2394-u ENGHITTksVKALss
0 1 S2395-p NGHITTksVKALssL
0 2 S2400-p TksVKALssLHGDDQ
0 13 S2401-p ksVKALssLHGDDQD
1 39 S2409-p LHGDDQDsEDEVLTI
0 1 R2425 EVKVHSGRGAGAESS
0 1 V2472 SSAQQKTVSSTKLVs
0 1 S2473 SAQQKTVSSTKLVsF
0 17 S2479-p VSSTKLVsFHDDsDE
1 61 S2484-p LVsFHDDsDEDLLHI
  mouse

 
T291 PSERREGTIPKLTAK
Y693 LSSTKLTYYDGMIQL
Y694 SSTKLTYYDGMIQLS
Y702 DGMIQLSYRNGTPYN
T1100 SMVRKPWTAVDTSAY
T1390-p NWEAVTRtGAtEHYL
T1393-p AVTRtGAtEHYLINV
T1821 STSTFKVTRDARTYS
A1824 TFKVTRDARTYSIGV
T1995 KFVQKHKTYDLRLLS
S2336 LTSCCRRSsGVSYKY
S2337-p TSCCRRSsGVSYKYS
K2342 RSsGVSYKYSKVSKE
Y2343 SsGVSYKYSKVSKEE
S2344 sGVSYKYSKVSKEEE
T2352-p KVSKEEEtDENETEW
K2384-u ENGHITTkAVKAEAL
A2385 NGHITTkAVKAEALs
S2392-p AVKAEALssLHGDDQ
S2393-p VKAEALssLHGDDQD
S2401-p LHGDDQDsEDEVLTV
R2417-m1 EVKVHSGrGAEVESS
T2464 RPGQRKPTAPAKLVs
A2465 PGQRKPTAPAKLVsF
S2471-p TAPAKLVsFHDDsDE
S2476-p LVsFHDDsDEDLLHI
  rat

 
T289 PSERREGTIPKLTAN
Y690 LSNTKLTYYDGMIQL
Y691 SNTKLTYYDGMIQLS
Y699 DGMIQLSYRNGTLYN
T1096 SMVRKPWTAVDTSVH
T1386 NWEAVTRTGATEHYL
T1389 AVTRTGATEHYLINV
T1817 STSTFKVTRDAHTYS
A1820 TFKVTRDAHTYSIGV
T1991 KFVQKHKTYDLRLLS
S2332-p LTNCCRRssGVSYKY
S2333-p TNCCRRssGVSYKYS
K2338 RssGVSYKYSKVSKE
Y2339 ssGVSYKYSKVSKEE
S2340 sGVSYKYSKVSKEEE
T2348-p KVSKEEEtDENETEW
K2380 ENGHITTKTVKAEAL
T2381 NGHITTKTVKAEALT
T2388 TVKAEALTSLHGDDQ
S2389 VKAEALTSLHGDDQD
S2397-p LHGDDQDsEDEVLTI
R2413 EVKVHTGRGAEVESS
T2460-p RPGQRKPttPAKLVs
T2461-p PGQRKPttPAKLVsF
S2467-p ttPAKLVsFHDDsDE
S2472-p LVsFHDDsDEDLLHI
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