Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
IGF2R (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IGF2R a multifunctional type I transmembrane protein receptor that binds insulin-like growth factor 2 at the cell surface and mannose-6-phosphate-tagged proteins in the trans-Golgi network. Also known as the cation-independent mannose-6 phosphate (M6P) receptor. Clears IGF2 from the cell surface to attenuate signaling, and transports M6P-tagged lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. M6P-tagged lysosomal enzymes bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Belongs to the MRL1/IGF2R family. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Vesicle protein; Membrane protein, integral
Chromosomal Location of Human Ortholog: 6q26
Cellular Component: extracellular space; trans-Golgi network transport vesicle; cell surface; clathrin coat; membrane; endocytic vesicle; perinuclear region of cytoplasm; nuclear envelope lumen; lysosomal membrane; integral to plasma membrane; late endosome; endosome
Molecular Function: mannose binding; identical protein binding; retinoic acid binding; transporter activity; phosphoprotein binding; G-protein alpha-subunit binding; receptor activity; insulin-like growth factor II binding; insulin-like growth factor receptor activity; G-protein coupled receptor activity; protein binding; enzyme binding; glycoprotein binding
Biological Process: receptor-mediated endocytosis; G-protein coupled receptor protein signaling pathway; organ regeneration; response to retinoic acid; insulin-like growth factor receptor signaling pathway; positive regulation of apoptosis; spermatogenesis; signal transduction; liver development; post-embryonic development
Reference #:  P11717 (UniProtKB)
Alt. Names/Synonyms: 300 kDa mannose 6-phosphate receptor; cation-independent mannose-6 phosphate receptor; Cation-independent mannose-6-phosphate receptor; CD222; CI Man-6-P receptor; CI-MPR; CIMPR; IGF-II receptor; IGF2R; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; M6P-R; M6P/IGF2 receptor; M6P/IGF2R; M6PR; MPR 300; MPR1; MPRI
Gene Symbols: IGF2R
Molecular weight: 274,375 Da
Basal Isoelectric point: 5.64  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

IGF2R

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T296-p PSERREGtIPKLtAK
0 1 T301-p EGtIPKLtAKSNCRY
0 1 Y484 ATDGKKRYDLSALVR
0 2 Y700-p LSNAKLSyyDGMIQL
0 2 Y701-p SNAKLSyyDGMIQLN
0 2 Y709-p DGMIQLNyRGGTPYN
0 1 T1107-p STVRKPWtAVDTSVD
0 1 T1272-p LSSDVCPtSDKSKVV
0 1 S1280-p SDKSKVVssCQEKRE
0 1 S1281-p DKSKVVssCQEKREP
0 1 R1286 VssCQEKREPQGFHK
0 1 T1346-p RPVFLKEtsDCSYLF
0 1 S1347-p PVFLKEtsDCSYLFE
0 1 T1397 NWEAITGTGDPEHYL
0 1 P1400 AITGTGDPEHYLINV
0 1 Y1592-p DQVLQLVyKDGSPCP
0 1 S1608 KSGLSYKSVISFVCR
0 1 S1611 LSYKSVISFVCRPEA
0 1 S1771-p FHCKRGVsMGtPKLL
0 1 T1774-p KRGVsMGtPKLLRTS
0 1 T1828-p STSTFKVtRDsRTYS
0 1 S1831-p TFKVtRDsRTYSVGV
0 1 S1865-p LSGTKGAsFGRLQsM
0 1 S1871-p AsFGRLQsMKLDYRH
0 1 T2002-p KFVQKHKtYDLRLLS
0 1 Y2024-p LVHNGVSyyINLCQK
0 1 Y2025-p VHNGVSyyINLCQKI
0 1 T2209-p HFSRKVGtsDKTKYY
0 1 S2210-p FSRKVGtsDKTKYYL
0 1 K2338 RRETVISKLTTCCRR
0 2 S2346-p LTTCCRRssNVSyky
0 26 S2347-p TTCCRRssNVSykys
0 1 Y2351-p RRssNVSykysKVNK
0 1 K2352-ac RssNVSykysKVNKE
0 1 K2352-ub RssNVSykysKVNKE
0 2 Y2353-p ssNVSykysKVNKEE
0 2 S2354-p sNVSykysKVNKEEE
0 2 T2362-p KVNKEEEtDENETEW
0 1 K2383 LPPPRQGKEGQENGH
0 3 K2394-ub ENGHITTksVKALss
0 1 S2395-p NGHITTksVKALssL
0 2 S2400-p TksVKALssLHGDDQ
0 15 S2401-p ksVKALssLHGDDQD
1 49 S2409-p LHGDDQDsEDEVLtI
0 4 T2415-p DsEDEVLtIPEVKVH
0 1 R2425 EVKVHSGRGAGAESS
0 1 V2472 SSAQQKTVSSTKLVs
0 1 S2473 SAQQKTVSSTKLVsF
0 20 S2479-p VSSTKLVsFHDDsDE
1 70 S2484-p LVsFHDDsDEDLLHI
  mouse

 
T291 PSERREGTIPKLTAK
T296 EGTIPKLTAKSNCRY
Y479 AINGKKRYDLSVLAR
Y693 LSSTKLTYYDGMIQL
Y694 SSTKLTYYDGMIQLS
Y702 DGMIQLSYRNGTPYN
T1100 SMVRKPWTAVDTSAY
A1265 LSSDVCSAHDGSKAV
S1273 HDGSKAVSSCQEKkG
S1274 DGSKAVSSCQEKkGP
K1279-ac VSSCQEKkGPQGFQK
T1339 KPVFLKETSDCSYMF
S1340 PVFLKETSDCSYMFE
T1390-p NWEAVTRtGAtEHYL
T1393-p AVTRtGAtEHYLINV
Y1585 DQVLQLVYENGSPCP
S1601-p LSDLRYKsVIsFVCR
S1604-p LRYKsVIsFVCRPEA
S1764 FHCKRGVSMGTPKLI
T1767 KRGVSMGTPKLIRTN
T1821 STSTFKVTRDARTYS
A1824 TFKVTRDARTYSIGV
S1858 LSGNKGASFGRLASM
S1864 ASFGRLASMQLDYRH
T1995 KFVQKHKTYDLRLLS
Y2017 FVHEGNSYFINLCQR
F2018 VHEGNSYFINLCQRV
T2202 HFSRKVGTSDMTKYY
S2203 FSRKVGTSDMTKYYV
K2328-ub RRETVINkLTSCCRR
S2336 LTSCCRRSsGVSYKY
S2337-p TSCCRRSsGVSYKYS
Y2341 RRSsGVSYKYSKVSK
K2342 RSsGVSYKYSKVSKE
K2342 RSsGVSYKYSKVSKE
Y2343 SsGVSYKYSKVSKEE
S2344 sGVSYKYSKVSKEEE
T2352-p KVSKEEEtDENETEW
K2373-ub VPAPRLGkDGQENGH
K2384-ub ENGHITTkAVKAEAL
A2385 NGHITTkAVKAEALs
S2392-p AVKAEALssLHGDDQ
S2393-p VKAEALssLHGDDQD
S2401-p LHGDDQDsEDEVLtV
T2407-p DsEDEVLtVPEVKVH
R2417-m1 EVKVHSGrGAEVESS
T2464 RPGQRKPTAPAKLVs
A2465 PGQRKPTAPAKLVsF
S2471-p TAPAKLVsFHDDsDE
S2476-p LVsFHDDsDEDLLHI
  rat

 
T289 PSERREGTIPKLTAN
T294 EGTIPKLTANCRYEV
Y475-p AIDGKKRyDLSVLAR
Y690 LSNTKLTYYDGMIQL
Y691 SNTKLTYYDGMIQLS
Y699 DGMIQLSYRNGTLYN
T1096 SMVRKPWTAVDTSVH
A1261 LSLDVCSAHDGSKAV
S1269 HDGSKAVSSCQEKKG
S1270 DGSKAVSSCQEKKGP
K1275 VSSCQEKKGPQGFQK
T1335 KPVFLKETLDCSYLF
L1336 PVFLKETLDCSYLFE
T1386 NWEAVTRTGATEHYL
T1389 AVTRTGATEHYLINV
Y1581 DQVLQLVYENGSPCP
S1597 KSGLRYKSVISFVCR
S1600 LRYKSVISFVCRPEA
S1760 FHCRRGISMGTPKLI
T1763 RRGISMGTPKLIRNN
T1817 STSTFKVTRDAHTYS
A1820 TFKVTRDAHTYSIGV
S1854 LSGSKGASFGRLASM
S1860 ASFGRLASMQLDYRH
T1991 KFVQKHKTYDLRLLS
Y2013 FVHEGNSYFINLCQR
F2014 VHEGNSYFINLCQRV
T2198 HFSRKVGTSDMTKYY
S2199 FSRKVGTSDMTKYYV
K2324 RRETVINKLTNCCRR
S2332-p LTNCCRRssGVSYKY
S2333-p TNCCRRssGVSYKYS
Y2337 RRssGVSYKYSKVSK
K2338 RssGVSYKYSKVSKE
K2338 RssGVSYKYSKVSKE
Y2339 ssGVSYKYSKVSKEE
S2340 sGVSYKYSKVSKEEE
T2348-p KVSKEEEtDENETEW
K2369 VPAPRLGKDGQENGH
K2380 ENGHITTKTVKAEAL
T2381 NGHITTKTVKAEALT
T2388 TVKAEALTSLHGDDQ
S2389 VKAEALTSLHGDDQD
S2397-p LHGDDQDsEDEVLTI
T2403 DsEDEVLTIPEVKVH
R2413 EVKVHTGRGAEVESS
T2460-p RPGQRKPttPAKLVs
T2461-p PGQRKPttPAKLVsF
S2467-p ttPAKLVsFHDDsDE
S2472-p LVsFHDDsDEDLLHI
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.