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Protein Page:
ENaC-gamma (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
ENaC-gamma Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Defects in SCNN1G are a cause of Liddle syndrome (LIDDS). It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel. Defects in SCNN1G are the cause of bronchiectasis with or without elevated sweat chloride type 3 (BESC3). A debilitating respiratory disease characterized by chronic, abnormal dilatation of the bronchi and other cystic fibrosis-like symptoms in the absence of known causes of bronchiectasis (cystic fibrosis, autoimmune diseases, ciliary dyskinesia, common variable immunodeficiency, foreign body obstruction). Clinical features include sub-normal lung function, sinopulmonary infections, chronic productive cough, excessive sputum production, and elevated sweat chloride in some cases. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1G subfamily. Note: This description may include information from UniProtKB.
Protein type: Transporter, ion channel; Membrane protein, multi-pass; Membrane protein, integral; Channel, sodium
Cellular Component: integral to plasma membrane; apical plasma membrane; plasma membrane; external side of plasma membrane
Molecular Function: amiloride-sensitive sodium channel activity; protein binding; WW domain binding; sodium channel activity
Biological Process: sensory perception of taste; sodium ion transport; response to stimulus; sodium ion homeostasis; multicellular organismal water homeostasis; excretion; transmembrane transport
Reference #:  P51170 (UniProtKB)
Alt. Names/Synonyms: amiloride-sensitive epithelial sodium channel gamma subunit; Amiloride-sensitive sodium channel subunit gamma; BESC3; ENaC gamma; ENaC gamma subunit; ENaC-gamma; ENaCG; ENaCgamma; Epithelial Na(+) channel subunit gamma; Gamma-ENaC; Gamma-NaCH; Nonvoltage-gated sodium channel 1 subunit gamma; PHA1; SCNEG; SCNN1G; SCNNG; sodium channel, nonvoltage-gated 1, gamma
Gene Symbols: SCNN1G
Molecular weight: 74,270 Da
Basal Isoelectric point: 7.47  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
Select Structure to View Below

ENaC-gamma

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 K6 __MAPGEKIKAKIKK
1 0 K8 MAPGEKIKAKIKKNL
1 0 K10 PGEKIKAKIKKNLPV
1 0 K12 EKIKAKIKKNLPVTG
1 0 K13 KIKAKIKKNLPVTGP
1 0 K26 GPQAPTIKELMRWYC
0 1 T98-p KLDFPAVtICNINPY
0 1 S108-p NINPYKYstVRHLLA
0 1 T109-p INPYKYstVRHLLAD
0 1 K495-ac QGRQVNKkLNkTDLA
0 1 K498-ac QVNKkLNkTDLAkLL
0 1 T499 VNKkLNkTDLAkLLI
0 1 K503-ac LNkTDLAkLLIFYKD
1 0 I598 QDNPALDIDDDLPTF
3 0 T622 LGTQVPGTPPPKYNt
0 1 T629-p TPPPKYNtLRLERAF
0 1 S637-p LRLERAFsNQLtDTQ
0 1 T641-p RAFsNQLtDTQMLDE
  mouse

 
K6 __MAPGEKIKAKIKK
K8 MAPGEKIKAKIKKNL
K10 PGEKIKAKIKKNLPV
K12 EKIKAKIKKNLPVRG
K13 KIKAKIKKNLPVRGP
K26 GPQAPTIKDLMHWYC
T98 KLDFPAVTICNINPY
S108 NINPYKYSAVSDLLT
A109 INPYKYSAVSDLLTD
K501 QSQQINKKLNKtDLA
K504 QINKKLNKtDLAKLL
T505-p INKKLNKtDLAKLLI
K509 LNKtDLAKLLIFYKD
T604 QDNPALDTDDDLPTF
T628 PEAPVPGTPPPRYNT
T635 TPPPRYNTLRLDSAF
S643 LRLDSAFSSQLTDTQ
T647 SAFSSQLTDTQLTNE
  rat

 
K6-ub __MAPGEkIkAkIkk
K8-ub MAPGEkIkAkIkkNL
K10-ub PGEkIkAkIkkNLPV
K12-ub EkIkAkIkkNLPVRG
K13-ub kIkAkIkkNLPVRGP
K26-ub GPQAPTIkDLMHWYC
T98 KLDFPAVTICNINPY
S108 NINPYKYSAVSDLLT
A109 INPYKYSAVSDLLTD
K496 QSQQINKKLNKTDLA
K499 QINKKLNKTDLAKLL
T500 INKKLNKTDLAKLLI
K504 LNKTDLAKLLIFYKD
T599-p QDNPALDtDDDLPTF
T623-p PGSTVPGtPPPRYNT
T630 tPPPRYNTLRLDRAF
S638 LRLDRAFSSQLTDTQ
T642 RAFSSQLTDTQLTNE
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