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FGF2
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue. Belongs to the heparin-binding growth factors family. 4 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Activator protein |
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Cellular Component: extracellular space; cytoplasm; extracellular region; nucleus
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Molecular Function: voltage-gated calcium channel activity; heparin binding; protein binding; fibroblast growth factor binding; growth factor activity; ligand-dependent nuclear receptor transcription coactivator activity; cytokine activity; chemoattractant activity; fibroblast growth factor receptor binding
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Biological Process: activation of MAPKK activity; activation of MAPK activity; regulation of cell cycle; positive regulation of transcription, DNA-dependent; adrenocorticotropin hormone secreting cell differentiation; hyaluronan catabolic process; substantia nigra development; positive chemotaxis; induction of an organ; positive regulation of cardiac muscle cell proliferation; nervous system development; fibroblast growth factor receptor signaling pathway; positive regulation of cell fate specification; positive regulation of blood vessel endothelial cell migration; negative regulation of blood vessel endothelial cell migration; regulation of calcium ion-dependent exocytosis; positive regulation of angiogenesis; nuclear translocation of MAPK; organ morphogenesis; cell migration during sprouting angiogenesis; positive regulation of cell division; phosphatidylinositol biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; negative regulation of transcription, DNA-dependent; wound healing; apoptosis; thyroid stimulating hormone secreting cell differentiation; signal transduction; chemotaxis; negative regulation of cell proliferation; synaptic transmission; glial cell differentiation; positive regulation of cell proliferation; regulation of retinal cell programmed cell death; embryonic morphogenesis; response to axon injury; positive regulation of granule cell precursor proliferation; positive regulation of phosphoinositide 3-kinase activity; regulation of angiogenesis; positive regulation of osteoblast differentiation; stem cell development; ureteric bud branching; release of sequestered calcium ion into cytosol; Ras protein signal transduction; insulin receptor signaling pathway; C21-steroid hormone biosynthetic process; negative regulation of cell growth; inositol phosphate biosynthetic process; lung development
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Reference #:
P09038 (UniProtKB)
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| Alt. Names/Synonyms: Basic fibroblast growth factor; basic fibroblast growth factor bFGF; BFGF; FGF2; FGFB; fibroblast growth factor 2; fibroblast growth factor 2 (basic); HBGF-2; Heparin-binding growth factor 2; prostatropin |
| Gene Symbols: FGF2 |
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Molecular weight: 30,770 Da
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Basal Isoelectric point: 11.18
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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