Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
FGF2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FGF2 Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue. Belongs to the heparin-binding growth factors family. 4 isoforms of the human protein are produced by alternative initiation. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Activator protein
Cellular Component: extracellular space; extracellular region; cytosol; nucleus
Molecular Function: heparin binding; protein binding; fibroblast growth factor binding; growth factor activity; ligand-dependent nuclear receptor transcription coactivator activity; cytokine activity; chemoattractant activity; fibroblast growth factor receptor binding
Biological Process: extracellular matrix organization and biogenesis; nerve growth factor receptor signaling pathway; activation of MAPKK activity; activation of MAPK activity; regulation of cell cycle; positive regulation of transcription, DNA-dependent; adrenocorticotropin hormone secreting cell differentiation; hyaluronan catabolic process; substantia nigra development; positive chemotaxis; induction of an organ; positive regulation of cardiac muscle cell proliferation; nervous system development; fibroblast growth factor receptor signaling pathway; positive regulation of cell fate specification; positive regulation of blood vessel endothelial cell migration; negative regulation of blood vessel endothelial cell migration; nuclear translocation of MAPK; positive regulation of angiogenesis; organ morphogenesis; cell migration during sprouting angiogenesis; positive regulation of cell division; phosphatidylinositol biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of endothelial cell proliferation; negative regulation of transcription, DNA-dependent; wound healing; thyroid stimulating hormone secreting cell differentiation; chemotaxis; signal transduction; negative regulation of cell proliferation; glial cell differentiation; positive regulation of cell proliferation; regulation of retinal cell programmed cell death; embryonic morphogenesis; response to axon injury; positive regulation of granule cell precursor proliferation; epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of phosphoinositide 3-kinase activity; regulation of angiogenesis; positive regulation of osteoblast differentiation; stem cell development; ureteric bud branching; release of sequestered calcium ion into cytosol; Ras protein signal transduction; insulin receptor signaling pathway; C21-steroid hormone biosynthetic process; innate immune response; negative regulation of cell growth; inositol phosphate biosynthetic process; lung development
Reference #:  P09038 (UniProtKB)
Alt. Names/Synonyms: Basic fibroblast growth factor; basic fibroblast growth factor bFGF; BFGF; FGF2; FGFB; fibroblast growth factor 2; fibroblast growth factor 2 (basic); HBGF-2; Heparin-binding growth factor 2; prostatropin
Gene Symbols: FGF2
Molecular weight: 30,770 Da
Basal Isoelectric point: 11.18  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FGF2

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
cell differentiation, altered: S250‑p
cell growth, altered: S250‑p
molecular association, regulation: S250‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S62-p PRSRAAGsPRtRGRR
0 1 T65-p RAAGsPRtRGRRTEE
1 0 R82-m2 SGSRLGDrGrGrALP
1 0 R84-m2 SRLGDrGrGrALPGG
1 0 R86-m2 LGDrGrGrALPGGRL
1 0 R96-m2 PGGRLGGrGrGRAPE
1 0 R98-m2 GRLGGrGrGRAPERV
1 0 R108-m2 APERVGGrGrGrGTA
1 0 R110-m2 ERVGGrGrGrGTAAP
1 0 R112-m2 VGGrGrGrGTAAPRA
0 1 S138-p AGTMAAGsITtLPAL
0 1 T141-p MAAGsITtLPALPED
2 0 K168-ac DPKRLYCkNGGFFLR
1 0 S206-p AEERGVVsIKGVCAN
1 0 Y215 KGVCANRYLAMKEDG
0 1 K228-ub DGRLLASkCVTDECF
1 2 Y245-p ERLESNNyNTYRsRK
1 0 S250-p NNyNTYRsRKytSWY
0 1 Y253-p NTYRsRKytSWYVAL
1 1 T254-p TYRsRKytSWYVALk
1 0 Y257 sRKytSWYVALkRTG
2 0 K261-ac tSWYVALkRTGQYkL
1 0 K267-ac LkRTGQYkLGSkTGP
1 0 K271-ac GQYkLGSkTGPGQkA
2 0 K277-ac SkTGPGQkAILFLPM
0 1 S285-p AILFLPMsAKs____
0 1 S288-p FLPMsAKs_______
  mouse

 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S4 ____MAASGITSLPA
S8 MAASGITSLPALPED
K34 DPKRLYCKNGGFFLR
S72 AEERGVVSIKGVCAN
Y81-p KGVCANRyLAMKEDG
K94 DGRLLASKCVTEECF
Y111-p ERLESNNyNTYRSRK
S116 NNyNTYRSRKYSSWy
Y119 NTYRSRKYSSWyVAL
S120 TYRSRKYSSWyVALK
Y123-p SRKYSSWyVALKRTG
K127 SSWyVALKRTGQYKL
K133 LKRTGQYKLGSKTGP
K137 GQYKLGSKTGPGQKA
K143 SKTGPGQKAILFLPM
S151 AILFLPMSAKS____
S154 FLPMSAKS_______
  rat

 
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
S5 ___MAAGSITSLPAL
S8 MAAGSITSLPALPED
K34 DPKRLYCKNGGFFLR
S72 AEERGVVSIKGVCAN
Y81 KGVCANRYLAMKEDG
K94 DGRLLASKCVTEECF
Y111 ERLESNNYNTYRSRK
S116 NNYNTYRSRKYSSWY
Y119 NTYRSRKYSSWYVAL
S120 TYRSRKYSSWYVALK
Y123 SRKYSSWYVALKRTG
K127 SSWYVALKRTGQYKL
K133 LKRTGQYKLGSKTGP
K137 GQYKLGSKTGPGQKA
K143 SKTGPGQKAILFLPM
S151 AILFLPMSAKS____
S154 FLPMSAKS_______
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.