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Protein Page:
ITGA6 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
ITGA6 Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21. Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). Belongs to the integrin alpha chain family. 8 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Receptor, misc.; Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion
Cellular Component: plasma membrane; integrin complex
Molecular Function: protein binding; metal ion binding
Biological Process: integrin-mediated signaling pathway; hemidesmosome assembly; positive regulation of apoptosis; cell-substrate junction assembly; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; cell adhesion; leukocyte migration; positive regulation of phosphorylation; negative regulation of apoptosis
Reference #:  P23229 (UniProtKB)
Alt. Names/Synonyms: CD49 antigen-like family member F; CD49f; DKFZp686J01244; FLJ18737; Integrin alpha-6; Integrin alpha-6 heavy chain; Integrin alpha-6 light chain; integrin alpha6B; integrin, alpha 6; ITA6; ITGA6; ITGA6B; VLA-6
Gene Symbols: ITGA6
Molecular weight: 126,633 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
CST Pathways:  GPCRs Signaling to MAPK/Erk  |  MAPK/Erk in Growth and Differentiation  |  PI3K/Akt Signaling  |  Regulation of Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ITGA6
Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 1 S13-p QLCLLYLsAGLLSRL
0 1 S85-p NRTGGLYsCDItARG
0 1 T89-p GLYsCDItARGPCTR
0 1 K110-u ADPTSESkEDQWMGV
0 1 S187-p RGHEKFGsCQQGVAA
0 1 K310-u SGKGIVSkDEITFVs
0 1 S317-p kDEITFVsGAPRANH
0 2 Y449-p DLGKVFIyHGSANGI
0 1 Y470-p VLKGISPyFGySIAG
0 2 Y473-p GISPyFGySIAGNMD
0 1 T512-p PVINIQKtITVTPNR
0 1 T560-p PSISIVGtLEAEKER
0 1 T588-p QGSEPKYtQELtLKR
0 1 T592-p PKYtQELtLKRQKQK
0 1 S624-p RPIPITAsVEIQEPS
0 1 S632-p VEIQEPSsRRRVNSL
0 1 S648-p EVLPILNsDEPKTAH
0 1 K698-u FSYLPIQkGVPELVL
0 1 T716-p KDIALEItVTNSPsN
0 1 S722-p ItVTNSPsNPRNPTK
0 1 T748 ATFPDTLTYSAYREL
0 1 S750 FPDTLTYSAYRELRA
0 1 Y752 DTLTYSAYRELRAFP
0 1 T825-p QDNLAPItAKAKVVI
0 1 T887-p KPLTNLGtAtLNIQW
0 1 T889-p LTNLGtAtLNIQWPK
0 1 S899-p IQWPKEIsNGKWLLY
0 1 T932-p EINSLNLtEsHNsRk
0 1 S934-p NSLNLtEsHNsRkKR
0 1 S937-p NLtEsHNsRkKREIT
0 1 K939-u tEsHNsRkKREITEK
0 1 N951 TEKQIDDNRKFSLFA
1 1 S1043-p VRVTVFPsKtVAQYS
0 1 T1045-p VTVFPsKtVAQYSGV
0 5 S1089 KRSRYDDSVPRYHAV
0 16 Y1093 YDDSVPRYHAVRIRk
0 1 K1100-a YHAVRIRkEEREIKD
0 16 Y1110-p REIKDEKyIDNLEKK
0 1 K1122-u EKKQWITkWNRNESy
0 4 Y1129-p kWNRNESyS______
0 4 - gap
0 1 - gap
0 1 - gap
  ITGA6 iso2  
S13 QLCLLYLSAGLLSRL
S85 NRTGGLYSCDITARG
T89 GLYSCDITARGPCTR
K110 ADPTSESKEDQWMGV
S187 RGHEKFGSCQQGVAA
K271 SGKGIVSKDEITFVS
S278 KDEITFVSGAPRANH
Y410 DLGKVFIYHGSANGI
Y431 VLKGISPYFGYSIAG
Y434 GISPYFGYSIAGNMD
T473 PVINIQKTITVTPNR
T521 PSISIVGTLEAEKER
T549 QGSEPKYTQELTLKR
T553 PKYTQELTLKRQKQK
S585 RPIPITASVEIQEPS
S593 VEIQEPSSRRRVNSL
S609 EVLPILNSDEPKTAH
K659 FSYLPIQKGVPELVL
T677 KDIALEITVTNSPSN
S683 ITVTNSPSNPRNPTK
T709 ATFPDTLTYSAYREL
S711 FPDTLTYSAYRELRA
Y713 DTLTYSAYRELRAFP
T786 QDNLAPITAKAKVVI
T848 KPLTNLGTATLNIQW
T850 LTNLGTATLNIQWPK
S860 IQWPKEISNGKWLLY
T893 EINSLNLTESHNSRK
S895 NSLNLTESHNSRKKR
S898 NLTESHNSRKKREIT
K900 TESHNSRKKREITEK
N912 TEKQIDDNRKFSLFA
S1004-p VRVTVFPsKTVAQYS
T1006 VTVFPsKTVAQYSGV
Y1050-p KRNKKDHyDATyHKA
Y1054-p KDHyDATyHKAEIHA
- gap
- gap
- gap
- gap
S1064-p AEIHAQPsDkERLtS
K1066-u IHAQPsDkERLtSDA
T1070-p PsDkERLtSDA____
  mouse

► Hide Isoforms 		 
S13 QLCLLYLSAGLLARL
S85 NRTGGLYSCDITSRG
T89 GLYSCDITSRGPCTR
K110 ADPMSESKEDQWMGV
S187 RGHEKFGSCQQGVAA
K271 SGKGIVSKDDITFVS
S278 KDDITFVSGAPRANH
Y410 DLGKVFIYHGSPTGI
Y431 VLEGTSPYFGYSIAG
Y434 GTSPYFGYSIAGNMD
T473 PVINILKTITVTPNR
I521 PPISILGILEAEKER
T549 QGSEPKYTQELTLNR
T553 PKYTQELTLNRQKQR
S585 RPIPITASVEIQEPS
S593 VEIQEPSSRRRVNSL
S609 EVLPILNSNEAKTVQ
K659 FSYLPIQKGIPELVL
T677 KDIALEITVTNSPSD
S683 ITVTNSPSDPRNPRK
T709 ATFPDTLTYSAYREL
S711 FPDTLTYSAYRELRA
Y713 DTLTYSAYRELRAFP
T786 QDNLAPITAKAKVVI
T848 KPLKNLGTATLNIQW
T850 LKNLGTATLNIQWPK
S860 IQWPKEISNGKWLLY
K893 EINYLKLKESHNSRK
S895 NYLKLKESHNSRKKR
S898 KLKESHNSRKKRELP
K900 KESHNSRKKRELPEK
S912-p PEKQIDDsRKFSLFP
S1004 VRVTVFPSKTVAQYS
T1006 VTVFPSKTVAQYSGV
S1050 KRSRYDDSIPRYHAV
Y1054 YDDSIPRYHAVRIRK
K1061 YHAVRIRKEEREIKD
H1071 REIKDEKHMDNLEKK
K1083 EKKQWITKWNENESY
Y1090 KWNENESYS______
- gap
- gap
- gap
  ITGA6 iso2  
S13 QLCLLYLSAGLLARL
S85 NRTGGLYSCDITSRG
T89 GLYSCDITSRGPCTR
K110 ADPMSESKEDQWMGV
S187 RGHEKFGSCQQGVAA
K271 SGKGIVSKDDITFVS
S278 KDDITFVSGAPRANH
Y410 DLGKVFIYHGSPTGI
Y431 VLEGTSPYFGYSIAG
Y434 GTSPYFGYSIAGNMD
T473 PVINILKTITVTPNR
I521 PPISILGILEAEKER
T549 QGSEPKYTQELTLNR
T553 PKYTQELTLNRQKQR
S585 RPIPITASVEIQEPS
S593 VEIQEPSSRRRVNSL
S609 EVLPILNSNEAKTVQ
K659 FSYLPIQKGIPELVL
T677 KDIALEITVTNSPSD
S683 ITVTNSPSDPRNPRK
T709 ATFPDTLTYSAYREL
S711 FPDTLTYSAYRELRA
Y713 DTLTYSAYRELRAFP
T786 QDNLAPITAKAKVVI
T848 KPLKNLGTATLNIQW
T850 LKNLGTATLNIQWPK
S860 IQWPKEISNGKWLLY
K893 EINYLKLKESHNSRK
S895 NYLKLKESHNSRKKR
S898 KLKESHNSRKKRELP
K900 KESHNSRKKRELPEK
S912 PEKQIDDSRKFSLFP
S1004 VRVTVFPSKTVAQYS
T1006 VTVFPSKTVAQYSGV
Y1050 KRNKKDHYDATYHKA
Y1054 KDHYDATYHKAEIHT
- gap
- gap
- gap
- gap
S1064 AEIHTQPSDKERLTS
K1066 IHTQPSDKERLTSDA
T1070 PSDKERLTSDA____
  rat

 
- gap
- gap
- gap
K11 ADPMSESKEDQWMGV
S88 RGHEKFGSCQQGVAA
K172 SGKGIVSKDDITFVS
S179 KDDITFVSGAPRANH
Y311-p DLGKVFIyHGSPTGI
F332 VLEGTTPFFGySIAG
Y335-p GTTPFFGySIAGNMD
T374 PVINILKTITVTPSR
I422 PPISILGILEAEKER
T450 QGSEPKYTQELTLNR
T454 PKYTQELTLNRQKQR
S486 RPIPITASVEIQEPS
S494 VEIQEPSSRRRVNSL
S510 EVLPILNSNEAKTVQ
K560 FSYLPIQKGIPELVL
T578 KDIALKITVTNGPSD
S584 ITVTNGPSDPRNPRK
T610-p ATFPDTLtYsAyREL
S612-p FPDTLtYsAyRELRA
Y614-p DTLtYsAyRELRAFP
T687 QDNLAPITAKAKVVI
T749 KPLKNLGTATLNIQW
T751 LKNLGTATLNIQWPK
S761 IQWPKEISNGKWLLY
K794 EINFLKLKESHNSRK
S796 NFLKLKESHNSRKKR
S799 KLKESHNSRKKRELP
K801 KESHNSRKKRELPEK
S813 PEKQIDDSRKFSLFS
S905 VRVTVFPSKTVAQYS
T907 VTVFPSKTVAQYSGI
Y951 KRNKKDHYDATYHKA
Y955 KDHYDATYHKAEIHT
- gap
- gap
- gap
- gap
S965 AEIHTQPSDKERLTS
K967 IHTQPSDKERLTSDA
T971 PSDKERLTSDA____
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