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Protein Page:
MYH9 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
MYH9 Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Interacts with PDLIM2. Interacts with SLC6A4. Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with RASIP1. Interacts with DDR1. Interacts with SVIL and HTRA3. In the kidney, expressed in the glomeruli. Also expressed in leukocytes. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Actin binding protein; Motility/polarity/chemotaxis; Motor protein
Cellular Component: cortical cytoskeleton; signalosome; protein complex; myosin II complex; leading edge; contractile ring; actomyosin; immunological synapse; cytosol; actin cytoskeleton; ruffle; cell-cell adherens junction; cytoplasm; plasma membrane; stress fiber; spindle; uropod; nucleus; integrin complex; neuromuscular junction; cleavage furrow
Molecular Function: microfilament motor activity; calmodulin binding; actin filament binding; protein binding; protein homodimerization activity; protein anchor; ATPase activity; motor activity; actin binding; actin-dependent ATPase activity; ADP binding; ATP binding
Biological Process: integrin-mediated signaling pathway; ATP catabolic process; axon guidance; monocyte differentiation; blood vessel endothelial cell migration; in utero embryonic development; actin filament-based movement; membrane protein ectodomain proteolysis; actomyosin structure organization and biogenesis; cytokinesis; uropod organization and biogenesis; establishment of meiotic spindle localization; regulation of cell shape; cell-cell adhesion; protein transport; actin cytoskeleton reorganization; establishment of T cell polarity; platelet formation; angiogenesis; leukocyte migration; myoblast fusion; meiotic spindle organization and biogenesis
Reference #:  P35579 (UniProtKB)
Alt. Names/Synonyms: Cellular myosin heavy chain, type A; DFNA17; EPSTS; FTNS; MGC104539; MHA; MYH9; MYH9 variant protein; Myosin heavy chain 9; Myosin heavy chain, non-muscle IIa; myosin, heavy chain 9, non-muscle; Myosin-9; NMHC-II-A; NMMHC II-a; NMMHC-A; NMMHC-IIA; NMMHCA; Non-muscle myosin heavy chain A; Non-muscle myosin heavy chain IIa; non-muscle myosin heavy polypeptide 9; nonmuscle myosin heavy chain II-A
Gene Symbols: MYH9
Molecular weight: 226,532 Da
Basal Isoelectric point: 5.5  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MYH9

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
cell motility, altered: S1943‑p
cytoskeletal reorganization: T1800‑p, S1803‑p, S1808‑p, S1943‑p
intracellular localization: T1800‑p, S1803‑p, S1808‑p, S1943‑p
molecular association, regulation: S1943‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 31 K8-a MAQQAADkyLyVDkN
0 1 K8-m3 MAQQAADkyLyVDkN
0 1 K8-u MAQQAADkyLyVDkN
0 7 Y9-p AQQAADkyLyVDkNF
0 134 Y11-p QAADkyLyVDkNFIN
1 0 K14 DkyLyVDKNFINNPL
0 1 K14-u DkyLyVDkNFINNPL
0 13 K29-a AQADWAAkkLVWVPs
0 2 K29-u AQADWAAkkLVWVPs
0 5 K30-a QADWAAkkLVWVPsD
0 1 K30 QADWAAkKLVWVPsD
0 1 S36-p kkLVWVPsDkSGFEP
0 1 K38-u LVWVPsDkSGFEPAS
0 14 K63-a VELVENGkKVKVNKD
0 1 K102-a ASVLHNLkERYYSGL
0 2 Y130-p PYKNLPIySEEIVEM
0 2 Y138-p SEEIVEMyKGKKRHE
0 1 K139 EEIVEMyKGKKRHEM
0 121 Y151-p HEMPPHIyAITDTAY
0 22 Y190-p NTKKVIQyLAyVAsS
0 18 Y193-p KVIQyLAyVAsSHKS
0 3 S196-p QyLAyVAsSHKSKKD
0 4 K225-u LEAFGNAkTVKNDNS
0 1 K299-a LLLEPYNkYRFLSNG
0 9 K299-u LLLEPYNkYRFLSNG
0 1 K316 TIPGQQDKDMFQETM
0 51 K355-a QLGNIVFkkERNTDQ
0 3 K355-u QLGNIVFkkERNTDQ
0 5 K356-a LGNIVFkkERNTDQA
0 2 K356-u LGNIVFkkERNTDQA
0 4 K373-u PDNTAAQkVSHLLGI
0 3 K403-u VGRDYVQkAQTKEQA
0 2 K439-a RINKALDkTKRQGAS
0 2 K540 WFPKATDKsFVEkVM
0 1 S541-p FPKATDKsFVEkVMQ
0 1 K545-a TDKsFVEkVMQEQGT
0 2 K545 TDKsFVEKVMQEQGT
0 1 K555 QEQGTHPKFQKPKQL
0 2 K606-u LLHQSSDkFVSELWK
0 3 K637-a TALPGAFktRKGMFR
0 9 K637-u TALPGAFktRKGMFR
0 2 T638-p ALPGAFktRKGMFRT
0 1 K651 RTVGQLYKEQLAKLM
0 1 K651-u RTVGQLYkEQLAKLM
0 4 K682-u NHEKKAGkLDPHLVL
0 3 Y721-p FQEFRQRyEILtPNS
0 4 T725-p RQRyEILtPNSIPKG
0 1 S751-p IKALELDsNLyRIGQ
0 752 Y754-p LELDsNLyRIGQskV
0 13 S759-p NLyRIGQskVFFRAG
0 23 K760-u LyRIGQskVFFRAGV
0 1 K810-u QQQLTAMkVLQRNCA
0 5 K821-u RNCAAYLkLRNWQWW
0 2 K833-u QWWRLFTkVkPLLQV
0 3 K835-u WRLFTkVkPLLQVSR
0 2 K850 QEEEMMAKEEELVKV
0 24 K860-u ELVKVREkQLAAENR
0 1 T869 LAAENRLTEMETLQS
0 22 H933 EEEERCQHLQAEKKK
0 8 K992-a DQNCKLAkEKKLLED
0 1 K1024-a SLAKLKNkHEAMITD
0 5 S1114 RELESQISELQEDLE
0 5 T1151-p LKTELEDtLdSTAAQ
0 2 D1153-ca TELEDtLdSTAAQQE
0 20 K1209-a AEQLEQTkRVKANLE
0 1 K1234-u GELANEVkVLLQGKG
0 1 T1269-p NEGERVRtELADkVT
0 1 K1274-a VRtELADkVTkLQVE
0 2 K1274-u VRtELADkVTkLQVE
0 3 K1277-u ELADkVTkLQVELDN
0 1 N1284 kLQVELDNVtGLLSQ
0 1 T1286-p QVELDNVtGLLSQSD
0 3 K1301-u SKSSKLTkDFSALES
0 1 K1357-a EAKHNLEkQIATLHA
0 2 K1370-a HAQVADMkkKMEDsV
0 2 K1371-a AQVADMkkKMEDsVG
0 2 S1376-p MkkKMEDsVGCLEtA
0 1 T1382-p DsVGCLEtAEEVKRK
0 1 K1392-a EVKRKLQkDLEGLSQ
0 2 K1392-u EVKRKLQkDLEGLSQ
0 1 K1404-a LSQRHEEkVAAyDkL
0 947 Y1408-p HEEkVAAyDkLEkTK
0 2 K1410-a EkVAAyDkLEkTKTR
0 8 K1413-u AAyDkLEkTKTRLQQ
0 55 K1441-a QSACNLEkkQKKFDQ
0 2 K1442-a SACNLEkkQKKFDQL
0 2 K1459-a EEKTISAkyAEERDR
0 5 Y1460-p EKTISAkyAEERDRA
0 1 K1566-u EVNLQAMkAQFERDL
0 11 K1584-a DEQSEEKkKQLVRQV
0 1 S1628-p DLEAHIDsANKNRDE
0 1 K1638-a KNRDEAIkQLRKLQA
0 11 S1714-p ADEIANSsGKGALAL
0 2 T1745-p LEEEQGNtELINDRL
1 2 G1799 VKLQEMEGtVKskYk
1 2 T1800-p KLQEMEGtVKskYkA
1 2 S1803-p EMEGtVKskYkAsIt
0 1 K1804-u MEGtVKskYkAsItA
0 1 Y1805 EGtVKskYkAsItAL
0 1 K1806-u GtVKskYkAsItALE
1 0 S1808-p VKskYkAsItALEAK
0 2 T1810-p skYkAsItALEAKIA
0 2 K1828-a EQLDNETkERQAACK
0 5 Y1861-p ERRNAEQyKDQADKA
0 2 T1906-p ELEDATEtADAMNRE
0 12 S1915-p DAMNREVssLKNKLR
5 9 S1916-p AMNREVssLKNKLRR
1 1 P1931 GDLPFVVPRRMARKG
2 107 A1939 RRMARKGAGDGsDEE
7 956 S1943-p RKGAGDGsDEEVDGK
5026 : Phospho-Myosin IIa (Ser1943) Antibody
  mouse

 
K8-a MAQQAADkyLyVDKN
K8 MAQQAADKyLyVDKN
K8 MAQQAADKyLyVDKN
Y9-p AQQAADkyLyVDKNF
Y11-p QAADkyLyVDKNFIN
K14 DkyLyVDKNFINNPL
K14 DkyLyVDKNFINNPL
K29-a AQADWAAkkLVWVPS
K29-u AQADWAAkkLVWVPS
K30-a QADWAAkkLVWVPSS
K30-u QADWAAkkLVWVPSS
S36 kkLVWVPSSKNGFEP
K38 LVWVPSSKNGFEPAS
K63-a VELVENGkKVKVNKD
K102 ASVLHNLKERYYSGL
Y130 PYKNLPIYSEEIVEM
Y138 SEEIVEMYkGKKRHE
K139-u EEIVEMYkGKKRHEM
Y151-p HEMPPHIyAITDTAY
Y190-p NTKKVIQyLAHVASS
H193 KVIQyLAHVASSHKS
S196 QyLAHVASSHKSKKD
K225-u LEAFGNAkTVKNDNS
K299 LLLEPYNKYRFLSNG
K299-u LLLEPYNkYRFLSNG
K316-u TIPGQQDkDMFQETM
K355-a QLGNIAFkkERNTDQ
K355-u QLGNIAFkkERNTDQ
K356-a LGNIAFkkERNTDQA
K356-u LGNIAFkkERNTDQA
K373-u PDNTAAQkVSHLLGI
K403-u VGRDYVQkAQTKEQA
K439 RINKALDKTKRQGAS
K540-u WFPKATDksFVEkVV
S541-p FPKATDksFVEkVVQ
K545 TDksFVEKVVQEQGT
K545-u TDksFVEkVVQEQGT
K555-u QEQGTHPkFQKPKQL
K606-u LLHQSSDkFVSELWK
K637-a TALPGAFkTRKGMFR
K637-u TALPGAFkTRKGMFR
T638 ALPGAFkTRKGMFRT
K651-a RTVGQLYkEQLAKLM
K651 RTVGQLYKEQLAKLM
K682-u NHEKKAGkLDPHLVL
Y721-p FQEFRQRyEILtPNS
T725-p RQRyEILtPNSIPKG
S751 IKALELDSNLyRIGQ
Y754-p LELDSNLyRIGQSkV
S759 NLyRIGQSkVFFRAG
K760-u LyRIGQSkVFFRAGV
K810 QQQLTAMKVLQRNCA
R821 RNCAAYLRLRNWQWW
K833 QWWRLFTKVkPLLNS
K835-u WRLFTKVkPLLNSIR
K850-u HEDELLAkEAELTKV
K860-u ELTKVREkHLAAENR
T869-p LAAENRLtEMETMQS
Y933-p EEEERCQyLQAEKKK
K992-a DQNCKLAkEKKLLED
K1024 SLAKLKNKHEAMITD
S1114-p RELETQIsELQEDLE
T1151 LKTELEDTLdSTAAQ
D1153-ca TELEDTLdSTAAQQE
K1209-a ADQLEQTkRVKATLE
K1234 GELANEVKALLQGKG
T1269 SEGERVRTELADkVT
K1274 VRTELADKVTkLQVE
K1274-u VRTELADkVTkLQVE
K1277-u ELADkVTkLQVELDs
S1284-p kLQVELDsVTGLLSQ
T1286 QVELDsVTGLLSQSD
K1301-u SKSSKLTkDFSALES
K1357 EAKRNLEKQIATLHA
K1370-a HAQVTDMkkKMEDGV
K1371-a AQVTDMkkKMEDGVG
G1376 MkkKMEDGVGCLETA
T1382 DGVGCLETAEEAKRR
K1392 EAKRRLQKDLEGLSQ
K1392-u EAKRRLQkDLEGLSQ
K1404 LSQRLEEKVAAyDKL
Y1408-p LEEKVAAyDKLEkTK
K1410 EKVAAyDKLEkTKTR
K1413-u AAyDKLEkTKTRLQQ
K1441 QSVSNLEKKQKKFDQ
K1442 SVSNLEKKQKKFDQL
K1459 EEKTISAKyAEERDR
Y1460-p EKTISAKyAEERDRA
K1566 EVNLQAMKAQFERDL
K1584-a DEQSEEKkKQLVRQV
T1628 DLEAHIDTANKNREE
K1638 KNREEAIKQLRKLQA
S1714-p ADEIANSsGKGALAL
T1745 LEEEQGNTELINDRL
S1799-p AKLQEMEsAVKsKyK
A1800 KLQEMEsAVKsKyKA
S1803-p EMEsAVKsKyKASIA
K1804 MEsAVKsKyKASIAA
Y1805-p EsAVKsKyKASIAAL
K1806 sAVKsKyKASIAALE
S1808 VKsKyKASIAALEAK
A1810 sKyKASIAALEAKIA
K1828 EQLDNETKERQAASK
F1861 ERRNAEQFKDQADKA
T1906 ELEDATETADAMNRE
S1915-p DAMNREVssLKNKLR
S1916-p AMNREVssLKNKLRR
T1931-p GDLPFVVtRRIVRKG
T1939-p RRIVRKGtGDCsDEE
S1943-p RKGtGDCsDEEVDGK
5026 : Phospho-Myosin IIa (Ser1943) Antibody
  rat

 
K8-a MAQQAADkYLYVDkN
K8 MAQQAADKYLYVDkN
K8 MAQQAADKYLYVDkN
Y9 AQQAADkYLYVDkNF
Y11 QAADkYLYVDkNFIN
K14-a DkYLYVDkNFINNPL
K14 DkYLYVDKNFINNPL
K29 AQADCGAKKLVWVPS
K29 AQADCGAKKLVWVPS
K30 QADCGAKKLVWVPST
K30 QADCGAKKLVWVPST
S36 KKLVWVPSTKNGFEP
K38 LVWVPSTKNGFEPAS
K63 VELVENGKKVKVNKD
K102 ASVLHNLKERYYSGL
Y130 PYKNLPIYSEEIVDM
Y138 SEEIVDMYKGKKRHE
K139 EEIVDMYKGKKRHEM
Y151 HEMPPHIYAITDTAY
Y190 NTKKVIQYLAHVASS
H193 KVIQYLAHVASSHKS
S196 QYLAHVASSHKSKKD
K225 LEAFGNAKTVKNDNS
K299 LLLEPYNKYRFLSNG
K299 LLLEPYNKYRFLSNG
K316 TIPGQQDKDMFQETM
K355 QLGNIVFKKERNTDQ
K355 QLGNIVFKKERNTDQ
K356 LGNIVFKKERNTDQA
K356 LGNIVFKKERNTDQA
K373 PDNTAAQKVSHLLGI
K403 VGRDYVQKAQTKEQA
K439 RINKALDKTKRQGAS
K540 WFPKATDKSFVEKVV
S541 FPKATDKSFVEKVVQ
K545 TDKSFVEKVVQEQGT
K545 TDKSFVEKVVQEQGT
K555 QEQGTHPKFQKPKQL
K606 LLHQSSDKFVSELWK
K637 TALPGAFKtRKGMFR
K637 TALPGAFKtRKGMFR
T638-p ALPGAFKtRKGMFRT
K651 RTVGQLYKEQLAKLM
K651 RTVGQLYKEQLAKLM
K682 NHEKKAGKLDPHLVL
Y721 FQEFRQRYEILTPNS
T725 RQRYEILTPNSIPKG
S751 IKALELDSNLYRIGQ
Y754 LELDSNLYRIGQSKV
S759 NLYRIGQSKVFFRSG
K760 LYRIGQSKVFFRSGV
K810 QQQLTAMKVLQRNCA
R821 RNCAAYLRLRNWQWW
K833 QWWRLFTKVKPLLNS
K835 WRLFTKVKPLLNSIR
K850 HEDELLAKEAELTKV
K860 ELTKVREKHLAAENR
T869 LAAENRLTEMETMQS
Y933 EEEERCQYLQAEKKK
K992 DQNCKLAKEKKLLED
K1024 SLAKLKNKHEAMITD
S1114-p RELETQIsELQEDLE
T1151 LKTELEDTLDSTAAQ
D1153 TELEDTLDSTAAQQE
K1209 AEQLEQTKRVKATLE
K1234 GELANEVKALLQGKG
T1269 SEGERVRTELADKVS
K1274 VRTELADKVSKLQVE
K1274 VRTELADKVSKLQVE
K1277 ELADKVSKLQVELDS
S1284 KLQVELDSVTGLLNQ
T1286 QVELDSVTGLLNQSD
K1301 SKSSKLTKDFSALES
K1358 EAKRNLEKQIATLHA
K1371 HAQVTDMKKKMEDGV
K1372 AQVTDMKKKMEDGVG
G1377 MKKKMEDGVGCLETA
T1383 DGVGCLETAEEAKRR
K1393 EAKRRLQKDLEGLSQ
K1393 EAKRRLQKDLEGLSQ
K1405 LSQRLEEKVAAyDKL
Y1409-p LEEKVAAyDKLEKTK
K1411 EKVAAyDKLEKTKTR
K1414 AAyDKLEKTKTRLQQ
K1442 QSVSNLEKKQKKFDQ
K1443 SVSNLEKKQKKFDQL
K1460 EEKTISAKYAEERDR
Y1461 EKTISAKYAEERDRA
K1567 EVNLQAMKAQFERDL
K1585 DEQSEEKKKQLVRQV
T1629 DLEAHIDTANKNREE
K1639 KNREEAIKQLRKLQA
S1715-p ADEIANSsGKGALAL
T1746 LEEEQGNTELINDRL
S1800-p AKLQEMEsAVKSKYK
A1801 KLQEMEsAVKSKYKA
S1804 EMEsAVKSKYKASIA
K1805 MEsAVKSKYKASIAA
Y1806 EsAVKSKYKASIAAL
K1807 sAVKSKYKASIAALE
S1809 VKSKYKASIAALEAK
A1811 SKYKASIAALEAKIA
K1829 EQLDNETKERQAASK
F1862 ERRNAEQFKDQADKA
T1907 ELEDATETADAMNRE
S1916 DAMNREVSsLKNKLR
S1917-p AMNREVSsLKNKLRR
T1932 GDMPFVVTRRIVRKG
T1940-p RRIVRKGtGDCsDEE
S1944-p RKGtGDCsDEEVDGK
5026 : Phospho-Myosin IIa (Ser1943) Antibody
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