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Protein Page:
GCG (human)

Overview
GCG Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. GLP-1 and GLP-2 are induced in response to nutrient ingestion. Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain. Belongs to the glucagon family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Hormone; Secreted
Cellular Component: extracellular space; endoplasmic reticulum lumen; extracellular region; plasma membrane
Molecular Function: identical protein binding; protein binding; hormone activity; glucagon receptor binding; receptor binding
Biological Process: positive regulation of protein binding; signal transduction; positive regulation of peptidyl-serine phosphorylation; G-protein signaling, coupled to cAMP nucleotide second messenger; response to starvation; cell proliferation; G-protein coupled receptor protein signaling pathway; cellular protein metabolic process; positive regulation of protein kinase activity; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; feeding behavior; regulation of insulin secretion; negative regulation of apoptosis
Reference #:  P01275 (UniProtKB)
Alt. Names/Synonyms: GCG; Glicentin; Glicentin-related polypeptide; GLP-1; GLP-1(7-36); GLP-1(7-37); GLP-2; GLP1; GLP2; GLUC; Glucagon; Glucagon-like peptide 1; Glucagon-like peptide 1(7-36); Glucagon-like peptide 1(7-37); Glucagon-like peptide 2; GRPP; OXM; OXY; Oxyntomodulin
Gene Symbols: GCG
Molecular weight: 20,909 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GCG

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T26-p WQRSLQDtEEKSRsF
0 1 S32-p DtEEKSRsFsAsQAD
0 1 S34-p EEKSRsFsAsQADPL
0 1 S36-p KSRsFsAsQADPLsD
0 1 S42-p AsQADPLsDPDQMNE
0 1 S54-p MNEDKRHsQGTFTSD
0 1 S60 HsQGTFTSDySKYLD
0 1 Y62-p QGTFTSDySKYLDsR
0 1 S68-p DySKYLDsRRAQDFV
0 1 T102 FERHAEGTFTSDVSS
0 1 S105 HAEGTFTSDVSSYLE
0 1 S108 GTFTSDVSSYLEGQA
0 1 S109 TFTSDVSSYLEGQAA
0 1 Y110 FTSDVSSYLEGQAAK
0 2 S150 GRRHADGSFSDEMNT
0 2 S152 RHADGSFSDEMNTIL
  mouse

 
T26 WQHALQDTEENPRSF
S32 DTEENPRSFPASQTE
P34 EENPRSFPASQTEAH
S36 NPRSFPASQTEAHED
E42 ASQTEAHEDPDEMNE
S54-p MNEDKRHsQGTFTsD
S60-p HsQGTFTsDYSKYLD
Y62 QGTFTsDYSKYLDSR
S68 DYSKYLDSRRAQDFV
T102-p FERHAEGtFTsDVss
S105-p HAEGtFTsDVssyLE
S108-p GtFTsDVssyLEGQA
S109-p tFTsDVssyLEGQAA
Y110-p FTsDVssyLEGQAAK
S150-p GRRHADGsFsDEMST
S152-p RHADGsFsDEMSTIL
  rat

 
T26 WQHAPQDTEENARSF
S32 DTEENARSFPASQTE
P34 EENARSFPASQTEPL
S36 NARSFPASQTEPLED
E42 ASQTEPLEDPDQINE
S54 INEDKRHSQGTFTSD
S60 HSQGTFTSDYSKYLD
Y62 QGTFTSDYSKYLDSR
S68 DYSKYLDSRRAQDFV
T102 FERHAEGTFTSDVSS
S105 HAEGTFTSDVSSYLE
S108 GTFTSDVSSYLEGQA
S109 TFTSDVSSYLEGQAA
Y110 FTSDVSSYLEGQAAK
S150-p GRRHADGsFsDEMNT
S152-p RHADGsFsDEMNTIL
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