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Protein Page:
GCG (human)

Overview
GCG Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon release is stimulated by hypoglycemia and inhibited by hyperglycemia, insulin, and somatostatin. GLP-1 and GLP-2 are induced in response to nutrient ingestion. Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain. Belongs to the glucagon family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide; Hormone
Cellular Component: extracellular space; endoplasmic reticulum lumen; extracellular region; plasma membrane
Molecular Function: identical protein binding; protein binding; hormone activity; glucagon receptor binding; receptor binding
Biological Process: response to starvation; G-protein signaling, coupled to cAMP nucleotide second messenger; cell proliferation; G-protein coupled receptor protein signaling pathway; cellular protein metabolic process; positive regulation of protein binding; positive regulation of protein kinase activity; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; feeding behavior; signal transduction; positive regulation of peptidyl-serine phosphorylation; regulation of insulin secretion; negative regulation of apoptosis
Reference #:  P01275 (UniProtKB)
Alt. Names/Synonyms: GCG; Glicentin; Glicentin-related polypeptide; GLP-1; GLP-1(7-36); GLP-1(7-37); GLP-2; GLP1; GLP2; GLUC; Glucagon; Glucagon-like peptide 1; Glucagon-like peptide 1(7-36); Glucagon-like peptide 1(7-37); Glucagon-like peptide 2; GRPP; OXM; OXY; Oxyntomodulin
Gene Symbols: GCG
Molecular weight: 20,909 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

GCG

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S36-p KSRSFSAsQADPLSD
0 1 S54-p MNEDKRHsQGTFTSD
0 1 S60 HsQGTFTSDYSKYLD
0 1 T102 FERHAEGTFTSDVSS
0 1 S105 HAEGTFTSDVSSYLE
0 1 S108 GTFTSDVSSYLEGQA
0 1 S109 TFTSDVSSYLEGQAA
0 1 Y110 FTSDVSSYLEGQAAK
0 2 S150 GRRHADGSFSDEMNT
0 2 S152 RHADGSFSDEMNTIL
  mouse

 
S36 NPRSFPASQTEAHED
S54-p MNEDKRHsQGTFTsD
S60-p HsQGTFTsDYSKYLD
T102-p FERHAEGtFTsDVss
S105-p HAEGtFTsDVssyLE
S108-p GtFTsDVssyLEGQA
S109-p tFTsDVssyLEGQAA
Y110-p FTsDVssyLEGQAAK
S150-p GRRHADGsFsDEMST
S152-p RHADGsFsDEMSTIL
  rat

 
S36 NARSFPASQTEPLED
S54 INEDKRHSQGTFTSD
S60 HSQGTFTSDYSKYLD
T102 FERHAEGTFTSDVSS
S105 HAEGTFTSDVSSYLE
S108 GTFTSDVSSYLEGQA
S109 TFTSDVSSYLEGQAA
Y110 FTSDVSSYLEGQAAK
S150 GRRHADGSFSDEMNT
S152 RHADGSFSDEMNTIL
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