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Protein Page:
Eomes (human)

Overview
Eomes Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. Up-regulated in CD8+ T-cells simultaneously stimulated with TGFB1 and IL4/interleukin-4. Expressed in CD8+ T-cells. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Cellular Component: nucleus
Molecular Function: DNA binding; sequence-specific DNA binding; chromatin binding; transcription factor activity
Biological Process: transcription, DNA-dependent; CD8-positive, alpha-beta T cell differentiation during immune response; regulation of neuron differentiation; olfactory bulb development; endodermal cell fate specification; positive regulation of transcription, DNA-dependent; stem cell maintenance; negative regulation of transcription from RNA polymerase II promoter; cerebral cortex regionalization; cerebral cortex neuron differentiation; trophectodermal cell differentiation; cardioblast differentiation; mesoderm formation; endoderm formation; interferon-gamma production; positive regulation of transcription from RNA polymerase II promoter; brain development; positive regulation of cell differentiation
Reference #:  O95936 (UniProtKB)
Alt. Names/Synonyms: EOMES; Eomesodermin homolog; eomesodermin homolog (Xenopus laevis); t box, brain, 2; T-box brain protein 2; T-brain-2; TBR-2; TBR2
Gene Symbols: EOMES
Molecular weight: 72,732 Da
Basal Isoelectric point: 6.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Eomes

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 S107-p PPDGRKGsPCGEEEL
0 1 S116 CGEEELPSAAAAAAA
0 4 S148-p SERYYLQsPGPQGSE
0 1 S216-p GPGAGAGsGAGGsSG
0 1 S221-p AGsGAGGsSGGGGGP
0 1 T385-p KGANNNNtQMIVLQS
0 2 - gap
0 1 - gap
0 1 - gap
0 1 S596 LPWTSRTSPTVFSED
0 2 T621-p IGSSWIEtPPSIKsL
0 1 S627-p EtPPSIKsLDSNDSG
0 1 S657-p SSNENSPsIKCEDIN
  Eomes iso3  
- gap
- gap
- gap
- gap
- gap
T90 KGANNNNTQMIVLQS
T176-p ASENDRLtPSPTDSP
S178 ENDRLtPSPTDSPRS
T180 DRLtPSPTDSPRSHQ
S320 LPWTSRTSPTVFSED
T345 IGSSWIETPPSIKSL
S351 ETPPSIKSLDSNDSG
S381 SSNENSPSIKCEDIN
  mouse

 
S117-p PPDGRKGsPCAEEEL
S126-p CAEEELPsAATAAAT
S150 SERYYLPSPGPQGSE
S218 GPAAGSGSGAGSSGG
S223 SGSGAGSSGGGAGGP
T387 KGANNNNTQMIVLQS
T473-p ASENDRLtPsPtDSP
S475-p ENDRLtPsPtDSPRS
T477-p DRLtPsPtDSPRSHQ
S617-p LPWTSRMsPPVFPED
T642 ISSSWIETPPSIKSL
S648 ETPPSIKSLDSSDSG
P678 PSNGNSPPIKCEDIN
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