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Protein Page:
Eomes (human)

Overview
Eomes Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. Up-regulated in CD8+ T-cells simultaneously stimulated with TGFB1 and IL4/interleukin-4. Expressed in CD8+ T-cells. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Cellular Component: nucleus
Molecular Function: DNA binding; sequence-specific DNA binding; chromatin binding; transcription factor activity
Biological Process: CD8-positive, alpha-beta T cell differentiation during immune response; regulation of neuron differentiation; endodermal cell fate specification; positive regulation of transcription, DNA-dependent; olfactory bulb development; stem cell maintenance; cerebral cortex regionalization; negative regulation of transcription from RNA polymerase II promoter; trophectodermal cell differentiation; cerebral cortex neuron differentiation; cardioblast differentiation; mesoderm formation; endoderm formation; interferon-gamma production; positive regulation of transcription from RNA polymerase II promoter; brain development; positive regulation of cell differentiation
Reference #:  O95936 (UniProtKB)
Alt. Names/Synonyms: EOMES; Eomesodermin homolog; eomesodermin homolog (Xenopus laevis); t box, brain, 2; T-box brain protein 2; T-brain-2; TBR-2; TBR2
Gene Symbols: EOMES
Molecular weight: 72,732 Da
Basal Isoelectric point: 6.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Eomes

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S107-p PPDGRKGsPCGEEEL
0 1 S116 CGEEELPSAAAAAAA
0 4 S148-p SERYYLQsPGPQGSE
0 1 - gap
0 1 - gap
0 1 - gap
0 1 S596 LPWTSRTSPTVFSED
0 2 T621-p IGSSWIEtPPSIKSL
  mouse

 
S117-p PPDGRKGsPCAEEEL
S126-p CAEEELPsAATAAAT
S150 SERYYLPSPGPQGSE
T473-p ASENDRLtPsPtDSP
S475-p ENDRLtPsPtDSPRS
T477-p DRLtPsPtDSPRSHQ
S617-p LPWTSRMsPPVFPED
T642 ISSSWIETPPSIKSL
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