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Eomes (human)

Overview Eomes Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. Up-regulated in CD8+ T-cells simultaneously stimulated with TGFB1 and IL4/interleukin-4. Expressed in CD8+ T-cells. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: DNA binding protein Cellular Component: nucleus Molecular Function: DNA binding; sequence-specific DNA binding; transcription factor activity Biological Process: CD8-positive, alpha-beta T cell differentiation during immune response; regulation of neuron differentiation; endodermal cell fate specification; olfactory bulb development; positive regulation of transcription, DNA-dependent; stem cell maintenance; negative regulation of transcription from RNA polymerase II promoter; trophectodermal cell differentiation; cerebral cortex neuron differentiation; mesoderm formation; endoderm formation; interferon-gamma production; positive regulation of transcription from RNA polymerase II promoter; brain development; positive regulation of cell differentiation Reference #:  O95936 (UniProtKB) Alt. Names/Synonyms: EOMES; Eomesodermin homolog; eomesodermin homolog (Xenopus laevis); t box, brain, 2; T-box brain protein 2; T-brain-2; TBR-2; TBR2 Gene Symbols: EOMES Molecular weight: 72,732 Da Basal Isoelectric point: 6.94  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Eomes

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  DISEASE  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S107-p	PPDGRKGsPCGEEEL
0	1		S116	CGEEELPSAAAAAAA
0	4		S148-p	SERYYLQsPGPQGSE
0	1		S216-p	GPGAGAGsGAGGsSG
0	1		S221-p	AGsGAGGsSGGGGGP
0	1		T385-p	KGANNNNtQMIVLQS
0	1		-	gap
0	1		-	gap
0	1		-	gap
0	1		S596	LPWTSRTSPTVFSED
0	2		T621-p	IGSSWIEtPPSIKsL
0	1		S627-p	EtPPSIKsLDSNDSG
0	1		S657-p	SSNENSPsIKCEDIN

	mouse
S117-p	PPDGRKGsPCAEEEL
S126-p	CAEEELPsAATAAAT
S150	SERYYLPSPGPQGSE
S218	GPAAGSGSGAGSSGG
S223	SGSGAGSSGGGAGGP
T387	KGANNNNTQMIVLQS
T473-p	ASENDRLtPsPtDSP
S475-p	ENDRLtPsPtDSPRS
T477-p	DRLtPsPtDSPRSHQ
S617-p	LPWTSRMsPPVFPED
T642	ISSSWIETPPSIKSL
S648	ETPPSIKSLDSSDSG
P678	PSNGNSPPIKCEDIN

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