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Protein Page:
APOA4 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
APOA4 May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. Synthesized primarily in the intestine and secreted in plasma. Belongs to the apolipoprotein A1/A4/E family. Note: This description may include information from UniProtKB.
Protein type: Lipid binding protein; Endoplasmic reticulum; Secreted, signal peptide; Cell adhesion; Secreted
Cellular Component: extracellular space; chylomicron; cell surface; endoplasmic reticulum lumen; early endosome; extracellular region; cytosol
Molecular Function: lipid transporter activity; antioxidant activity; protein homodimerization activity; copper ion binding; cholesterol transporter activity; phosphatidylcholine binding; lipid binding
Biological Process: multicellular organismal lipid catabolic process; cholesterol metabolic process; positive regulation of fatty acid biosynthetic process; phototransduction, visible light; removal of superoxide radicals; lipid homeostasis; protein-lipid complex assembly; lipoprotein metabolic process; cholesterol efflux; lipid transport; phosphatidylcholine metabolic process; cholesterol homeostasis; leukocyte adhesion; reverse cholesterol transport; regulation of cholesterol absorption; phospholipid efflux; innate immune response in mucosa; hydrogen peroxide catabolic process; response to lipid hydroperoxide; positive regulation of lipoprotein lipase activity; regulation of cholesterol transport; retinoid metabolic process
Reference #:  P06727 (UniProtKB)
Alt. Names/Synonyms: Apo-AIV; ApoA-IV; APOA4; Apolipoprotein A-IV; Apolipoprotein A4; MGC142154; MGC142156
Gene Symbols: APOA4
Molecular weight: 45,399 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

APOA4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K51 EAVEHLQKSELTQQL
0 1 E136 RELQQRLEPYADQLR
0 2 A333 RQKLGPHAGDVEGHL
  mouse

 
K51-a EAVEQFQkTDVTQQL
K136-a QKLQEHLkPYAVDLQ
S333-p RQQLGPNsGEVESHL
  rat

 
K51 EAVEQLQKTDVTQQL
R136 QKLQEHLRPYATDLQ
S333 RQQLGSDSGDVESHL
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