|
ApoA4
May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. Synthesized primarily in the intestine and secreted in plasma. Belongs to the apolipoprotein A1/A4/E family. Note: This description may include information from UniProtKB.
|
| Protein type: Transporter; Endoplasmic reticulum; Lipid binding protein; Secreted; Secreted, signal peptide; Cell adhesion |
|
Cellular Component: extracellular space; chylomicron; cell surface; endoplasmic reticulum lumen; extracellular region
|
|
Molecular Function: antioxidant activity; lipid transporter activity; protein homodimerization activity; copper ion binding; eukaryotic cell surface binding; cholesterol transporter activity; phosphatidylcholine binding; lipid binding
|
|
Biological Process: multicellular organismal lipid catabolic process; cholesterol metabolic process; positive regulation of fatty acid biosynthetic process; removal of superoxide radicals; protein-lipid complex assembly; lipid homeostasis; lipoprotein metabolic process; cholesterol efflux; lipid transport; phosphatidylcholine metabolic process; leukocyte adhesion; cholesterol homeostasis; reverse cholesterol transport; innate immune response in mucosa; phospholipid efflux; regulation of cholesterol absorption; response to lipid hydroperoxide; hydrogen peroxide catabolic process; positive regulation of lipoprotein lipase activity; lipid metabolic process; regulation of cholesterol transport
|
|
Reference #:
P06727 (UniProtKB)
|
| Alt. Names/Synonyms: Apo-AIV; ApoA-IV; APOA4; Apolipoprotein A-IV; Apolipoprotein A4; MGC142154; MGC142156 |
| Gene Symbols: APOA4 |
|
Molecular weight: 45,399 Da
|
|
Basal Isoelectric point: 5.28
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
|
