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Protein Page:
APOA4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
APOA4 May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons. Synthesized primarily in the intestine and secreted in plasma. Belongs to the apolipoprotein A1/A4/E family. Note: This description may include information from UniProtKB.
Protein type: Secreted, signal peptide; Secreted; Lipid binding protein; Endoplasmic reticulum; Cell adhesion
Chromosomal Location of Human Ortholog: 11q23
Cellular Component: extracellular space; chylomicron; cell surface; endoplasmic reticulum lumen; early endosome; extracellular region; cytosol
Molecular Function: antioxidant activity; lipid transporter activity; protein homodimerization activity; copper ion binding; cholesterol transporter activity; phosphatidylcholine binding; lipid binding
Biological Process: multicellular organismal lipid catabolic process; positive regulation of fatty acid biosynthetic process; cholesterol metabolic process; phototransduction, visible light; removal of superoxide radicals; lipid homeostasis; protein-lipid complex assembly; lipoprotein metabolic process; cholesterol efflux; lipid transport; phosphatidylcholine metabolic process; leukocyte adhesion; cholesterol homeostasis; reverse cholesterol transport; regulation of cholesterol absorption; phospholipid efflux; innate immune response in mucosa; hydrogen peroxide catabolic process; response to lipid hydroperoxide; positive regulation of lipoprotein lipase activity; regulation of cholesterol transport; retinoid metabolic process
Reference #:  P06727 (UniProtKB)
Alt. Names/Synonyms: Apo-AIV; ApoA-IV; APOA4; Apolipoprotein A-IV; Apolipoprotein A4; MGC142154; MGC142156
Gene Symbols: APOA4
Molecular weight: 45,399 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

APOA4

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K51 EAVEHLQKSELTQQL
0 1 E136 RELQQRLEPYADQLR
0 1 A150 RTQVNTQAEQLRRQL
0 1 Y310-p FRRRVEPyGENFNKA
0 2 A333 RQKLGPHAGDVEGHL
0 1 K350 LEKDLRDKVNSFFST
0 1 E360 SFFSTFKEKESQDKT
0 1 K361 FFSTFKEKESQDKTL
  mouse

 
K51-ac EAVEQFQkTDVTQQL
K136-ac QKLQEHLkPYAVDLQ
T150-p QDQINTQtQEMKLQL
M310 FRRTVEPMGEMFNKA
S333-p RQQLGPNsGEVESHL
K350-ac LEKSLREkVNSFMST
K360-ac SFMSTLEkkGSPDQP
K361-ac FMSTLEkkGSPDQPQ
  rat

 
K51 EAVEQLQKTDVTQQL
R136 QKLQEHLRPYATDLQ
T150 QAQINAQTQDMKRQL
L310 FRRAVEPLGDKFNMA
S333-p RQQLGSDsGDVESHL
K350 LEKNLREKVSSFMST
K360 SFMSTLQKKGSPDQP
K361 FMSTLQKKGSPDQPL
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