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SSTR1 (human)

Overview SSTR1 Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins. Belongs to the G-protein coupled receptor 1 family. Interacts with SKB1. Note: This description may include information from UniProtKB. Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Cell cycle regulation Cellular Component: integral to plasma membrane; plasma membrane Molecular Function: somatostatin receptor activity Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of cell proliferation; cell surface receptor linked signal transduction; cell-cell signaling; glutamate signaling pathway; digestion; response to nutrient Reference #:  P30872 (UniProtKB) Alt. Names/Synonyms: G-protein coupled receptor; somatostatin receptor 1; Somatostatin receptor type 1; SRIF-2; SS-1-R; SS1-R; SS1R; SSR1; SSTR1 Gene Symbols: SSTR1 Molecular weight: 42,686 Da Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SSTR1

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T118-p	VPFLVTStLLRHWPF
0	1		S135-p	LLCRLVLsVDAVNMF
0	2		S364	ALKSRAYSVEDFQPE
0	2		S375	FQPENLESGGVFRNG
0	1		T383-p	GGVFRNGtCtSRITT
0	1		T385-p	VFRNGtCtSRITTL_

	mouse
T118	VPFLVTSTLLRHWPF
S135	LLCRLVLSVDAVNMF
S364-p	ALKSRAYsVEDFQPE
S375-p	FQPENLEsGGVFRNG
T383	GGVFRNGTCASRIST
A385	VFRNGTCASRISTL_

	rat
T118	VPFLVTSTLLRHWPF
S135	LLCRLVLSVDAVNMF
S364	ALKSRAYSVEDFQPE
S375	FQPENLESGGVFRNG
T383	GGVFRNGTCASRIST
A385	VFRNGTCASRISTL_

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