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Phlda3 (human)

Overview Phlda3 p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its directs transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May acts as a tumor suppressor. Belongs to the PHLDA3 family. Induced by p53/TP53; expression is directly activated by p53/TP53. p53/TP53 phosphorylation on 'Ser-15' is required to activate the PHLDA3 promoter. Note: This description may include information from UniProtKB. Cellular Component: intracellular membrane-bound organelle; cytoplasm; plasma membrane Molecular Function: phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-5-phosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol 3-phosphate binding Biological Process: anatomical structure morphogenesis; negative regulation of protein kinase B signaling cascade; induction of apoptosis; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis Reference #:  Q9Y5J5 (UniProtKB) Alt. Names/Synonyms: PHLA3; PHLDA3; Pleckstrin homology-like domain family A member 3; pleckstrin homology-like domain, family A, member 2; pleckstrin homology-like domain, family A, member 3; TDAG51/Ipl homolog 1; TIH1 Gene Symbols: PHLDA3 Molecular weight: 13,891 Da Basal Isoelectric point: 9.72  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Phlda3

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T122	RARQsLGTGTLVS__

	mouse
T120-p	RARQSLGtGTLVS__

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