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Protein Page:
Tbx4 (human)

Overview
Tbx4 Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Defects in TBX4 are the cause of small patella syndrome (SPS); also known as ischiopatellar dysplasia or Scott-Taor syndrome. SPS is an autosomal dominant skeletal dysplasia characterized by patellar aplasia or hypoplasia and by anomalies of the pelvis and feet, including disrupted ossification of the ischia and inferior pubic rami. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein
Chromosomal Location of Human Ortholog: 17q21-q22
Cellular Component: nucleus
Molecular Function: DNA binding; transcription factor activity
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; skeletal morphogenesis; multicellular organismal development; morphogenesis of an epithelium; angiogenesis; limb morphogenesis; embryonic limb morphogenesis; lung development
Reference #:  P57082 (UniProtKB)
Alt. Names/Synonyms: SPS; T-box 4; T-box protein 4; T-box transcription factor TBX4; TBX4
Gene Symbols: TBX4
Molecular weight: 60,204 Da
Basal Isoelectric point: 7.34  Predict pI for various phosphorylation states
Select Structure to View Below

Tbx4

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S99-p AGRRMFPsYKVKVtG
0 1 T105-p PsYKVKVtGMNPKTK
0 1 Y127 VPADDHRYKFCDNKW
0 1 S360-p SYLEAPSsVGEDHYF
0 1 S379 PYDQQMLSPSYCSEV
0 1 S507 GCERKPPSPHLNAAN
  mouse

 
S104 AGRRMFPSYKVKVTG
T110 PSYKVKVTGMNPKTK
Y132 VPADDHRYKFCDNKW
S367 SYLETPSSVGDDHYF
S386-p PYDQQMLsPSYCSEV
S514-p MCERKPPsPHLNTAN
  rat

 
S107 AGRRMFPSYKVKVTG
T113 PSYKVKVTGMNPKTK
Y135-p VPADDHRyKFCDNKW
S370 SYLETPSSVGDDHYF
S389 PYDQQMLSPSYCSEV
S516 VCERKPPSPHLNTAN
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