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Epac1 (human)

Overview Epac1 Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Guanine nucleotide exchange factor, misc. Cellular Component: membrane; plasma membrane; endomembrane system; cAMP-dependent protein kinase complex Molecular Function: protein binding; guanyl-nucleotide exchange factor activity; cAMP-dependent protein kinase regulator activity; cAMP binding Biological Process: cell proliferation; platelet activation; regulation of small GTPase mediated signal transduction; positive regulation of angiogenesis; small GTPase mediated signal transduction; energy reserve metabolic process; angiogenesis; blood coagulation; signal transduction; regulation of insulin secretion Reference #:  O95398 (UniProtKB) Alt. Names/Synonyms: 9330170P05Rik; bcm910; cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I; CGEF1; EPAC; EPAC 1; EPAC1; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; HSU79275; MGC21410; Rap guanine nucleotide exchange factor (GEF) 3; Rap guanine nucleotide exchange factor 3; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; RAPGEF3; RPGF3 Gene Symbols: RAPGEF3 Molecular weight: 103,751 Da Basal Isoelectric point: 7.28  Predict pI for various phosphorylation states CST Pathways:  GPCRs Signaling to MAPK/Erk  |  MAPK/Erk in Growth and Differentiation Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Epac1

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S79	RWTPLTNSEESLDFS
0	1		K268-a	LLFEPHSkAGTVLFS
0	1		K347	QDFNRIIKDVEAKTM
0	1		T380-p	AGPSRPPtPGRNRYT
0	2		S528	ENGCGNASPQMKARN
0	4		S864-p	SHNPVPLsPLRSRVS
0	1		S886	VARISTCSEQSLSTR
0	1		S889	ISTCSEQSLSTRSPA

	mouse
S79-p	RWTPLTNsEDSLDFR
K268	LLFEPHSKAGTVLFS
K347-u	QDFNRIIkDVEAKTM
T380-p	AGPSRPPtPGRNRYT
S531-p	ENGCGNVsPQTKARN
S859-p	SHSTAPLsPLRSRVS
S881-p	GSRISTCsEQsLSTR
S884-p	ISTCsEQsLSTRSPA

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