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Protein Page:
Epac1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Epac1 Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Widely expressed with highest levels in adult kidney, heart, thyroid and brain, and fetal kidney. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GEFs; GEFs, misc.
Chromosomal Location of Human Ortholog: 12q13.1
Cellular Component: membrane; plasma membrane; endomembrane system; cAMP-dependent protein kinase complex
Molecular Function: protein binding; Rap guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; cAMP-dependent protein kinase regulator activity; cAMP binding
Biological Process: platelet activation; positive regulation of Rap GTPase activity; signal transduction; cell proliferation; positive regulation of angiogenesis; cAMP-mediated signaling; positive regulation of stress fiber formation; energy reserve metabolic process; positive regulation of cAMP catabolic process; angiogenesis; regulation of protein kinase activity; blood coagulation; regulation of insulin secretion; Rap protein signal transduction
Reference #:  O95398 (UniProtKB)
Alt. Names/Synonyms: 9330170P05Rik; bcm910; cAMP-GEFI; cAMP-regulated guanine nucleotide exchange factor I; CGEF1; EPAC; EPAC 1; EPAC1; Exchange factor directly activated by cAMP 1; Exchange protein directly activated by cAMP 1; HSU79275; MGC21410; Rap guanine nucleotide exchange factor (GEF) 3; Rap guanine nucleotide exchange factor 3; Rap1 guanine-nucleotide-exchange factor directly activated by cAMP; RAPGEF3; RPGF3
Gene Symbols: RAPGEF3
Molecular weight: 103,751 Da
Basal Isoelectric point: 7.28  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Epac1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S79 RWTPLTNSEEsLDFS
0 1 S82-p PLTNSEEsLDFSESL
0 1 S267-p VLLFEPHskAGTVLF
0 1 K268-ac LLFEPHskAGTVLFS
0 1 K347 QDFNRIIKDVEAKTM
0 1 T380-p AGPSRPPtPGRNRYT
0 3 S528 ENGCGNASPQMKARN
0 4 S864-p SHNPVPLsPLRSRVS
0 1 S886 VARISTCSEQSLSTR
0 1 S889 ISTCSEQSLSTRSPA
  mouse

 
S79-p RWTPLTNsEDSLDFR
S82 PLTNsEDSLDFRVSL
S267 VLLFEPHSKAGTVLF
K268 LLFEPHSKAGTVLFS
K347-ub QDFNRIIkDVEAKTM
T380-p AGPSRPPtPGRNRYT
S531-p ENGCGNVsPQTKARN
S859-p SHSTAPLsPLRSRVS
S881-p GSRISTCsEQsLSTR
S884-p ISTCsEQsLSTRSPA
  rat

 
S79 RWTPLTNSEGSLDFR
S82 PLTNSEGSLDFRVSL
S267 VLLFEPHSKAGTVLF
K268 LLFEPHSKAGTVLFS
K347 QDFNRIIKDVEAKTM
T380 AGPSRPPTPGRNRYT
S531-p ENGCGNVsPQTKARN
S867 SHSTAPLSPLRSRVS
S889 ASRISTCSEQSLSTR
S892 ISTCSEQSLSTRSPA
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