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Protein Page:
DLL3 (human)

DLL3 Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. Can bind and activate Notch-1 or another Notch receptor. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Cell development/differentiation
Chromosomal Location of Human Ortholog: 19q13
Cellular Component: integral to membrane
Molecular Function: Notch binding
Biological Process: compartment specification; paraxial mesoderm development; somitogenesis; Notch signaling pathway; skeletal development; negative regulation of neurogenesis
Disease: Spondylocostal Dysostosis 1, Autosomal Recessive
Reference #:  Q9NYJ7 (UniProtKB)
Alt. Names/Synonyms: delta-like 3 (Drosophila); Delta-like protein 3; Delta3; DLL3; Drosophila Delta homolog 3; SCDO1
Gene Symbols: DLL3
Molecular weight: 64,618 Da
Basal Isoelectric point: 7.86  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


0 1 T119-p FRDAWPGtFsFIIEt
0 1 S121-p DAWPGtFsFIIEtWR
0 1 T126-p tFsFIIEtWREELGD

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