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DLL3 (human)

Overview DLL3 Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm. Can bind and activate Notch-1 or another Notch receptor. Note: This description may include information from UniProtKB. Protein type: Cell development/differentiation; Membrane protein, integral Cellular Component: integral to membrane Molecular Function: Notch binding Biological Process: paraxial mesoderm development; compartment specification; Notch signaling pathway; positive regulation of neurogenesis; somitogenesis; central nervous system development; negative regulation of astrocyte differentiation; negative regulation of Notch signaling pathway; skeletal development Reference #:  Q9NYJ7 (UniProtKB) Alt. Names/Synonyms: delta-like 3 (Drosophila); Delta-like protein 3; Delta3; DLL3; Drosophila Delta homolog 3; SCDO1 Gene Symbols: DLL3 Molecular weight: 64,618 Da Basal Isoelectric point: 7.86  Predict pI for various phosphorylation states CST Pathways:  Notch Signaling

Select Structure to View Below DLL3

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  DISEASE 277300 602768  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T119-p	FRDAWPGtFsFIIEt
0	1		S121-p	DAWPGtFsFIIEtWR
0	1		T126-p	tFsFIIEtWREELGD

	mouse
T117	FRDAWPGTFSLVIET
S119	DAWPGTFSLVIETWR
T124	TFSLVIETWREQLGE

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