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Protein Page:
Ugt1a6a (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Ugt1a6a UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - retinol; Xenobiotic Metabolism - drug metabolism - other enzymes; Membrane protein, integral; Xenobiotic Metabolism - metabolism by cytochrome P450; Carbohydrate Metabolism - pentose and glucuronate interconversions; EC 2.4.1.17; Mitochondrial; Transferase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Carbohydrate Metabolism - ascorbate and aldarate; Lipid Metabolism - androgen and estrogen; Carbohydrate Metabolism - starch and sucrose
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane
Molecular Function: enzyme binding; retinoic acid binding; protein homodimerization activity; glucuronosyltransferase activity; protein heterodimerization activity
Biological Process: xenobiotic metabolic process
Reference #:  P19224 (UniProtKB)
Alt. Names/Synonyms: GNT1; HLUGP; HLUGP1; MGC29860; Phenol-metabolizing UDP-glucuronosyltransferase; UD16; UDP glucuronosyltransferase 1 family, polypeptide A6; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1 family polypeptide A6s; UDP-glucuronosyltransferase 1-6; UDP-glucuronosyltransferase 1-F; UDP-glucuronosyltransferase 1A6; UDPGT; UDPGT 1-6; UGT-1F; UGT1; UGT1*6; UGT1-06; UGT1.6; UGT1A6; UGT1A6S; UGT1F
Gene Symbols: UGT1A6
Molecular weight: 60,751 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
Select Structure to View Below

Ugt1a6a

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y91-p QEELKNRyQsFGNNH
0 1 S93-p ELKNRyQsFGNNHFA
0 1 Y220-p LVNLLEPyLFyCLFs
0 2 Y223-p LLEPyLFyCLFsKyE
0 1 S227-p yLFyCLFsKyEELAS
0 1 Y229-p FyCLFsKyEELASAV
0 11 K352 ANNTILVKWLPQNDL
0 1 K436-ac VINDKSYkENIMRLS
  mouse

 
F91 LEELQTRFRTFGNNH
T93 ELQTRFRTFGNNHFL
Y220 IVNILENYLYYCLYS
Y223 ILENYLYYCLYSKYE
S227 YLYYCLYSKYEIIAS
Y229 YYCLYSKYEIIASDL
K351-ac AKNTILVkWLPQNDL
K435 VINNKSYKENIMRLS
  rat

 
Y90 LEELRTRYRSFGNNH
S92 ELRTRYRSFGNNHFA
Y218 IANILENYLYHCLYS
H221 ILENYLYHCLYSKYE
S225 YLYHCLYSKYEILAS
Y227 YHCLYSKYEILASDL
K349-ac AKNTILVkWLPQNDL
K433 VINNKSYKENIMRLS
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