Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
Ugt1a6a (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Ugt1a6a UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Belongs to the UDP-glycosyltransferase family. 1 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Lipid Metabolism - androgen and estrogen; Xenobiotic Metabolism - drug metabolism - other enzymes; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Mitochondrial; Cofactor and Vitamin Metabolism - retinol; Membrane protein, integral; EC 2.4.1.17; Transferase; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - starch and sucrose; Xenobiotic Metabolism - metabolism by cytochrome P450; Carbohydrate Metabolism - pentose and glucuronate interconversions
Cellular Component: endoplasmic reticulum membrane; integral to membrane
Molecular Function: protein homodimerization activity; enzyme binding; retinoic acid binding; protein heterodimerization activity; glucuronosyltransferase activity
Biological Process: xenobiotic metabolic process
Reference #:  P19224 (UniProtKB)
Alt. Names/Synonyms: GNT1; HLUGP; HLUGP1; MGC29860; Phenol-metabolizing UDP-glucuronosyltransferase; UD16; UDP glucuronosyltransferase 1 family, polypeptide A6; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1 family polypeptide A6s; UDP-glucuronosyltransferase 1-6; UDP-glucuronosyltransferase 1-F; UDP-glucuronosyltransferase 1A6; UDPGT; UDPGT 1-6; UGT-1F; UGT1; UGT1*6; UGT1-06; UGT1.6; UGT1A6; UGT1A6S; UGT1F
Gene Symbols: UGT1A6
Molecular weight: 60,751 Da
Basal Isoelectric point: 8.66  Predict pI for various phosphorylation states
Select Structure to View Below

Ugt1a6a

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  ENZYME  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 2 Y223-p LLEPYLFyCLFSKYE
0 10 K352 ANNTILVKWLPQNDL
  mouse

 
Y223 ILENYLYYCLYSKYE
K351-a AKNTILVkWLPQNDL
  rat

 
H221 ILENYLYHCLYSKYE
K349 AKNTILVKWLPQNDL
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.